Wolfgang Preiser
A5089704709- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- BIM and Construction Integration
National Health Laboratory Service
2016-2025
Stellenbosch University
2016-2025
Tygerberg Hospital
2008-2025
Impact Assessment
2022
Western Cape Department of Health
2022
South African Medical Research Council
2017-2022
City of Cape Town
2022
University of Cape Town
2022
University of KwaZulu-Natal
2013-2022
University of Cincinnati
1998-2017
BackgroundAbstractThe severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.MethodsClinical specimens from patients with were searched for viruses the use of cell cultures and molecular techniques.ResultsA novel coronavirus was in SARS. The virus isolated culture, sequence 300 nucleotides length obtained polymerase-chain-reaction (PCR)–based random-amplification procedure. Genetic...
Abstract The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. first was associated with a mix of lineages, while the second and third waves were driven Beta (B.1.351) Delta (B.1.617.2) variants, respectively 1–3 . In November 2021, genomic surveillance teams South Botswana detected new variant rapid resurgence infections Gauteng province, Africa. Within days genome being uploaded, it designated concern (Omicron, B.1.1.529) World Health Organization and,...
Summary Continued uncontrolled transmission of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in many parts world is creating conditions for significant virus evolution. Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations spike protein, including three at important residues receptor-binding domain (K417N, E484K and N501Y) that may have functional significance. This emerged South Africa after first epidemic wave...
Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible. For an effective immune prophylaxis in humans, broad coverage of different strains SARS-CoV and control potential neutralization escape variants will be required. Combinations virus-neutralizing, noncompeting mAbs may have these properties.Human mAb CR3014 has been shown to completely prevent lung pathology abolish...
Abstract Three lineages (BA.1, BA.2 and BA.3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant concern predominantly drove South Africa’s fourth Coronavirus Disease 2019 (COVID-19) wave. We have now identified two new lineages, BA.4 BA.5, responsible for a fifth wave infections. The spike proteins BA.5 are identical, similar to except addition 69–70 deletion (present in Alpha BA.1 lineage), L452R Delta variant), F486V wild-type amino acid at Q493. differ...
The SARS-coronavirus (SARS-CoV) is a newly emerged, highly pathogenic agent that caused over 8,000 human infections with nearly 800 deaths between November 2002 and September 2003. While direct person-to-person transmission via respiratory droplets accounted for most cases, other modes have not been ruled out. Faecal shedding common prolonged has an outbreak in Hong Kong. We studied the stability of SARS-CoV under different conditions, both suspension dried on surfaces, comparison...
ABSTRACT The emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes lethal infections mainly on the Arabian Peninsula. evolutionary origins of MERS-CoV are unknown. We determined full genome sequence a CoV directly from fecal material obtained South African Neoromicia capensis bat (NeoCoV). NeoCoV shared essential details architecture with MERS-CoV. Eighty-five percent was identical to at nucleotide level. Based taxonomic criteria, and belonged one viral species. presence...
The first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in South Africa was identified on 5 March 2020, and by 26 the country full lockdown (Oxford stringency index of 90)1. Despite early response, November over 785,000 people were infected, which accounted for approximately 50% all known African infections2. In this study, we analyzed 1,365 near whole genomes report identification 16 new lineages SARS-CoV-2 isolated between 6 August 2020. Most these have unique...
The objective was to compare COVID-19 outcomes in the Omicron-driven fourth wave with prior waves Western Cape, assess contribution of undiagnosed infection differences a context high seroprevalence due and determine whether protection against severe disease conferred by and/or vaccination maintained.
Abstract South Africa’s fourth COVID-19 wave was driven predominantly by three lineages (BA.1, BA.2 and BA.3) of the SARS-CoV-2 Omicron variant concern. We have now identified two new lineages, BA.4 BA.5. The spike proteins BA.5 are identical, comparable to except for addition 69-70del, L452R, F486V wild type amino acid at Q493. 69-70 deletion in allows these be proxy marker S-gene target failure with TaqPath™ qPCR assay. rapidly replaced BA.2, reaching more than 50% sequenced cases Africa...
The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. first was associated with a mix of lineages, while the second and third waves were driven Beta (B.1.351) Delta (B.1.617.2) variants, respectively1–3. In November 2021, genomic surveillance teams South Botswana detected new variant rapid resurgence infections Gauteng province, Africa. Within days genome being uploaded, it designated concern (Omicron, B.1.1.529) World Health Organization and, within...
Mpox was previously thought to be a zoonotic disease endemic in parts of central, west, and east Africa; however, from 2022 2023, large global outbreak mpox clade II monkeypox virus occurred, marking the first instance sustained transmission outside Africa since case human identified 1970.1WHOMonkeypox – United Kingdom Great Britain Northern Ireland.https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON383Date: May 18, 2022Date accessed: March 24, 2024Google Scholar More...
Post‐occupancy evaluation (POE) is a diagnostic tool and system which allows facility managers to identify evaluate critical aspects of building performance systematically. This has been applied problem areas in existing buildings, test new prototypes develop design guidance criteria for future facilities. Outlines the numerous benefits POE, including better space utilization, as well cost time savings. Describes conceptual framework data‐gathering techniques. Presents examples outcomes case...
SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) in China. No active or passive immunoprophylaxis for disease induced by is available. We investigated prophylaxis infection with a neutralising human monoclonal antibody ferrets, which can be readily infected the virus. Prophylactic administration at 10 mg/kg reduced replication lungs ferrets 3·3 logs (95% Cl 2·6–4·0 logs; p<0·001), completely prevented development coronavirus-induced macroscopic...
Monoclonal antibodies (MAbs) neutralizing West Nile Virus (WNV) have been shown to protect against infection in animal models and identified as a correlate of protection WNV vaccine studies. In the present study, antibody repertoires from three convalescent WNV-infected patients were cloned into an scFv phage library, 138 human MAbs binding identified. One hundred twenty-one specifically bound viral envelope (E) protein four premembrane (prM) protein. Enzyme-linked immunosorbent assay-based...
Hepatitis A virus (HAV) is an ancient and ubiquitous human pathogen recovered previously only from primates. The sole species of the genus Hepatovirus, existing in both enveloped nonenveloped forms, with a capsid structure intermediate between that insect viruses mammalian picornaviruses, HAV enigmatic its origins. We conducted targeted search for hepatoviruses 15,987 specimens collected 209 small mammal globally discovered highly diversified bats, rodents, hedgehogs, shrews, which by...