Meredith Yeager
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Prostate Cancer Treatment and Research
- BRCA gene mutations in cancer
- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Telomeres, Telomerase, and Senescence
- Nutrition, Genetics, and Disease
- Renal cell carcinoma treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sarcoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
National Cancer Institute
2016-2025
Division of Cancer Epidemiology and Genetics
2015-2025
Frederick National Laboratory for Cancer Research
2016-2025
Lundbeck (United States)
2025
Hood College
2024-2025
Leidos Biomedical Research Inc. (United States)
2015-2024
National Institutes of Health
2015-2024
Leidos (United States)
2015-2024
Center for Cancer Research
2005-2023
Cancer Genetics (United States)
2005-2022
African genomics and skin color Skin varies among human populations is thought to be under selection, with light maximizing vitamin D production at higher latitudes dark providing UV protection in equatorial zones. To identify the genes that give rise palette of tones, Crawford et al. applied genome-wide analyses across diverse (see Perspective by Tang Barsh). Genetic variants were identified likely function phenotypes. Comparison model organisms verified a conserved MFSD12 pigmentation. A...
Significance The EPIGEN Brazil Project is the largest Latin-American initiative to study genomic diversity of admixed populations and its effect on phenotypes. We studied 6,487 Brazilians from three population-based cohorts with different geographic demographic backgrounds. identified ancestry components these at a previously unmatched resolution. broadened our understanding African diaspora, principal destination which was Brazil, by revealing an component that likely derives slave trade...
<h3>Importance</h3> Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations. The genetic susceptibility to osteosarcoma outside familial remains unclear. <h3>Objective</h3> To investigate architecture 1244 patients with osteosarcoma. <h3>Design, Setting, Participants</h3> Whole-exome sequencing (n = 1104) or targeted 140) DNA from 10 participating...
Genome-wide association studies (GWASs), now as a routine approach to study single-nucleotide polymorphism (SNP)-trait association, have uncovered over ten thousand significant trait/disease associated SNPs (TASs). Here, we updated GWASdb (GWASdb v2, http://jjwanglab.org/gwasdb) which provides comprehensive data curation and knowledge integration for GWAS TASs. These updates include: (i) Up August 2015, collected 2479 unique publications from PubMed other resources; (ii) We further curated...
Background: HPV16 is a common sexually transmitted infection although few infections lead to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only certain progress. can be classified into four main evolutionary-derived variant lineages (A, B, C, D) that have been previously suggested varying disease risks.