Chin‐Fu Hsiao
A5054249064- Statistical Methods in Clinical Trials
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Optimal Experimental Design Methods
- Health Systems, Economic Evaluations, Quality of Life
- Pneumocystis jirovecii pneumonia detection and treatment
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Lung Cancer Research Studies
- HIV/AIDS drug development and treatment
- Genetic Associations and Epidemiology
- Biosimilars and Bioanalytical Methods
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Hepatitis B Virus Studies
National Health Research Institutes
2016-2025
Taipei City Hospital
2013-2024
Shiga University of Medical Science
2019
National Taiwan University
2003-2017
National Yang Ming Chiao Tung University
2013-2017
Institute of Population and Public Health
2016
FH Foundation
2016
National Cancer Institute
2015
Cancer Genetics (United States)
2015
University College London
2015
To make large-scale association studies a reality, automated high-throughput methods for genotyping with single-nucleotide polymorphisms (SNPs) are needed. We describe PCR conditions that permit the use of TaqMan or 5′ nuclease allelic discrimination assay typing large numbers individuals any SNP and computational allow genotypes to be assigned automatically. demonstrate utility these methods, we typed >1600 G-to-T transversion results in glutamate-to-aspartate substitution at position...
Genome-wide association studies of lung cancer reported in populations European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that achieved genome-wide significance with p-values 10−7 or lower. These been performed primarily cigarette smokers, raising the possibility observed associations could be related to tobacco use, carcinogenesis, both. Since most women Asia do not smoke, we conducted a study adenocarcinoma never-smoking females (584 cases, 585...
Lung cancer is the leading cause of death worldwide as well in Taiwan. Interleukin-6 (IL-6) a multifunctional cytokine and has been implicated tumor progression. This study recruited 245 patients with advanced (Stage 3B/4) nonsmall cell lung (NSCLC) that had received chemotherapy, to evaluate associations between IL-6 cancer-specific survival. Among these subjects, 112 gave blood samples before 133 after start chemotherapy. Plasma was measured using an enzyme linked-immunosorbent assay. The...
In Brief Objective: To investigate the clinical efficacy of adjuvant interferon alfa-2b (IFNα-2b) therapy on recurrence-free survival (RFS) patients with postoperative viral hepatitis-related hepatocellular carcinoma (HCC). Background: Despite most individual trials have failed to meet their primary endpoint, recent pooled-data meta-analyses suggest that IFN may significantly reduce incidence recurrence in curatively ablated HCC. Methods: Patients curative resection HCC were eligible, and...
Concurrent chemoradiotherapy (CCRT) is superior to radiotherapy alone for treating locoregionally advanced nasopharyngeal carcinoma (NPC). Whether adding induction chemotherapy (IC) further improves the outcome warrants investigation.This open-label multicenter phase III trial was conducted at 11 institutions in Taiwan. Patients with stage IVA or IVB NPC were randomized receive IC followed by CCRT (I-CCRT) alone. I-CCRT arm received three cycles of mitomycin C, epirubicin, cisplatin, and...
Objective In this study, we evaluated the efficacy of hydroxychloroquine (HCQ) against coronavirus disease 2019 (COVID-19) via a randomized controlled trial (RCT) and retrospective study. Methods Subjects admitted to 11 designated public hospitals in Taiwan between April 1 May 31, 2020, with COVID-19 diagnosis confirmed by pharyngeal real-time RT-PCR for SARS-CoV-2, were at 2:1 ratio stratified mild or moderate illness. HCQ (400 mg twice d 200 daily 6 days) was administered. Both study...
Abstract Purpose: For treatment decision and prognostic applications, we evaluated p53/epidermal growth factor receptor (EGFR) somatic aberrations in multiple primary lung cancers to differentiate multifocal tumors from intrapulmonary metastasis. Experimental Design: Fifty-eight of 1,037 patients a 10-year period were identified investigate mutations altered expression p53 EGFR for clonality assessment. Genomic DNA was extracted microdissected cells paraffin-embedded cancer tissues....
Incidence of Entamoeba histolytica infection and clinical manifestations treatment response invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before.At the National Taiwan University Hospital, medical records who received a diagnosis IA between 1994 2005 were reviewed. The incidence was serial blood stool samples from 670 264 patients, respectively, using serological specific amebic antigen assays. DNA extracted containing E. analyzed by PCR, sequenced, compared....
Recent evidence from several relatively small nested case‐control studies in prospective cohorts shows an association between longer telomere length measured phenotypically peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere‐length associated genetic variants large study 5,457 never‐smoking female Asian cases 4,493 controls using data previously reported genome‐wide study. Using group...
Abstract Background Exercise, nutrition, and psychological interventions may all have positive impacts on frailty sarcopenia. However, it is not known whether an integrated care programme with three components can be beneficial the intensity of such also certain. In this study, we aim to determine effectiveness two levels Methods A randomized control trial was conducted at community hospitals in Taiwan. Older adults (65–79 years age, N = 289) who scored ≥1 Cardiovascular Health Study...
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping an additional 10,780 cases and 10,938 controls from Asia confirmed with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), overall risk, rs3817963 (6p21.3, BTNL2) which is...
Smoking tobacco is the major risk factor for developing lung cancer. However, most Han Chinese women with cancer are nonsmokers. cooking methods usually generate various carcinogens in fumes that may inevitably be inhaled by those who cook food, of whom female. We investigated associations habits and exposure to among non-smoking women. This study was conducted on 1,302 cases matched healthy controls Taiwan during 2002-2010. Two indices, "cooking time-years" "fume extractor use ratio," were...
Abstract The COVID-19 pandemic struck the world unguarded, some places outperformed others in containment. This longitudinal study considered a comparative evaluation of containment across 50 distinctly governed regions between March 2020 and November 2021. Our analysis distinguishes pre-vaccine phase (March–November 2020) vaccinating (December 2020–November 2021). In first phase, we develop an indicator, termed lockdown efficiency (LE), to estimate efficacy measures against monthly case...
Background: Whether risk of invasive amebiasis due to Entamoeba histolytica is higher among human immunodeficiency virus (HIV)-infected persons than uninfected remains unclear, although intestinal colonization by dispar common men who have sex with men.Our objective was determine the prevalence and E in HIV-infected controls. Methods:We assessed case review 951 serologic studies 634 persons, 429 controls gastrointestinal symptoms, 178 healthy using indirect hemagglutination antibody assay.We...
Background. Carriage and subsequent infection with methicillin resistant S. aureus (MRSA) its transmission between hospital community settings have not been studied in dialysis patients their contacts. Methods. Surveillance for nasal MRSA carriage among patients, healthcare workers (HCWs) family members a centre was prospectively undertaken during three time periods within 1 year. Molecular typing used to determine epidemiological relationship. Results. Among 1687 samples collected,...
Between June 1994 and February 2003, a total of 111 human immunodeficiency virus (HIV)-infected patients with chronic hepatitis B (HBV) coinfection 387 HIV-infected without HBV or C were prospectively observed to assess the impact infection on outcomes patients. After median duration observation 25 months, coinfected more likely develop (adjusted hazard ratio [AHR], 2.54; 95% confidence interval [CI], 1.69-3.82) hepatic decompensation odds [AOR], 9.94; CI, 1.89-52.35). Although similar...
We extensively allelotyped a panel of 71 microdissected primary surgically resected non small cell lung cancer (NSCLC) tumors to identify chromosomal regions that are likely contain tumor suppressor genes (TSGs) or associated with clinicopathologic and prognostic effects. Loss heterozygosity (LOH) was detected by genotyping 177 microsatellite markers correlation LOH parameters prognosis analyzed. Twenty showed an frequency greater than 48%, 8 them (2p23.3, 2p24.3, 2q35, 6p22.2, 7p14.3,...
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway, which primary mechanism for of DNA damage caused by oxidation and alkylation. We hypothesized that polymorphisms APE1 are associated with risk lung cancer. In hospital-based matched case-control study, a total 730 cancer cases cancer-free controls were genotyped four haplotype-tagging (that is, -656T>G, 400A>G, 630T>C, 1350T>G). Among them, single-nucleotide polymorphism -656T>G located...
Methadone is a racemic compound composed of the R-form and S-form enantiomers. The drug usually used in maintenance therapy for heroin-addicted patients. In our previous study, we found that cytochrome P-450 (CYP) isozyme 2B6 preferentially metabolizes S-methadone enantiomer. We thus tested whether CYP2B6 gene polymorphisms had any influence on concentration or clearance methadone. Ten single nucleotide within this region were evaluated 366 patients undergoing methadone at least 3 months....
Summary Background Deregulation of mammalian target rapamycin ( mTOR ) signalling is common in human hepatocellular carcinoma HCC ). Aim To determine the maximum tolerated dose MTD oral inhibitor everolimus advanced patients. Methods Patients with locally or metastatic (Child‐Pugh class A B) were enrolled an open‐label phase 1 study and randomly assigned to daily (2.5–10 mg) weekly (20–70 a standard 3 + dose‐escalation design. was based on rate dose‐limiting toxicities DLT s). Secondary...