A5055663794- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Glycosylation and Glycoproteins Research
- Blood properties and coagulation
- Autoimmune Bullous Skin Diseases
- Medical Imaging Techniques and Applications
- Bacterial Identification and Susceptibility Testing
- Respiratory Support and Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Pleural and Pulmonary Diseases
- Platelet Disorders and Treatments
- Mycobacterium research and diagnosis
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Occupational and environmental lung diseases
Tokyo Medical and Dental University
2019-2025
Showa University Fujigaoka Hospital
2024
Shinshu University
2012-2021
Shinshu University Hospital
2012-2021
Nihon University
2021
University of Brawijaya
2021
Kochi Rehabilitation Institute
2021
Juntendo University
2021
Gunma University
2021
National Cancer Centre Japan
2017-2020
The aim of this study was to evaluate the usefulness annual screening for lung cancer by low-dose computed tomography (CT) and characteristics identified cancers. Subjects consisted 5483 general population aged 40–74 years, who received initial CT scans in 1996, followed repeat most subjects 1997 1998, with a total 13 786 taken during 1996–1998. Work-up examinations patients suspicious lesions were conducted using diagnostic CTs. 1996 detected nodules 279 (5.1%) subjects, 22 (8%) confirmed...
This study describes the clinical characteristics of patients with CPFE and compares these COPD. It should therefore be noteworthy that prevalence lung cancer might high in patients.Patients combined pulmonary fibrosis emphysema (CPFE) are sometimes seen, we speculate have some different from COPD patients. clarifies patients.This was a retrospective 47 stable concurrent diffuse parenchymal disease fibrosis, based on findings chest CT (CPFE patients). The were compared those...
Mammalian neocortex has a laminated structure that develops in birth-date-dependent “inside-out” pattern. This layered is established by neuronal migration with sequential changes of the migratory mode regulated several signaling cascades, including Reelin–Disabled homolog 1 (Dab1) pathway. Although importance “locomotion,” major mode, been well established, physiological significance change from locomotion to “terminal translocation,” final unknown. In this study, we found outermost region...
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of in cohort Japanese individuals collected during initial waves pandemic, with 3,289 unaffected controls. We identified variant on chromosome 5 at 5q35 (rs60200309-A), close to dedicator cytokinesis 2 gene (DOCK2), which was associated patients less than 65 years age. This risk allele prevalent East Asian but rare...
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 disease 2019 (COVID-19) patients 75 healthy controls Japanese ancestry with host genetic data. COVID-19 showed a low fraction nonclassical monocytes (ncMono). report downregulated transitions classical to ncMono reduced CXCL10 expression...
CT Findings and Progression of Small Peripheral Lung Neoplasms Having a Replacement Growth PatternShodayu Takashima1, Yuichiro Maruyama1, Minoru Hasegawa1, Takeshi Yamanda2, Takayuki Honda3, Masumi Kadoya1 Shusuke Sone4Audio Available | Share
The purpose of this study was to determine the correlation between high-resolution CT morphologic features small peripheral lung adenocarcinomas and tumor growth patterns.We examined 59 small, surgically resected (diameter, 6-20 mm) that were detected on screening for cancer using low-dose helical CT. Among these adenocarcinomas, 14 (24%) visible 45 (76%) invisible conventional chest radiography. patterns analyzed.Sixteen (94%) 17 type A (Noguchi's classification) appeared as nodules pure...
Conventional chest radiography (CXR) is a poor diagnostic tool for detecting lung cancers at surgically curable stage. To determine the visibility of peripheral small on CXR, we retrospectively examined usefulness CXR using consecutive series 44 cases detected CT screening and later confirmed by histopathology. All had been low dose during population based trial cancer. The control group consisted 48 radiographs normal subjects. Tumour diameters ranged from 6 mm to 45 mm, with 95% (42/44) <...
Objective and background: The present study was performed to clarify the clinical characteristics of patients with COPD classified into phenotypes according dominancy emphysema presence bronchial wall thickening (BWT) evaluated by chest high‐resolution CT. Methods A total 172 stable (FEV 1 < 80%) were examined Emphysematous changes BWT visually, three phenotypes: absence emphysema, little or without (A phenotype), (E phenotype) phenotype (M phenotype). compared among phenotypes. Results...
Autoimmune pancreatitis (AIP) has been recently proposed as a disease entity, and an elevated serum IgG4 level is characteristic finding in it. This sometimes associated with other inflammatory diseases, such retroperitoneal fibrosis sclerosing cholangitis. To elucidate the clinicopathological characteristics of AIP‐associated prostatitis (AIP‐P), findings AIP‐P patients were evaluated, immunohistochemical expression IgG subclasses (IgG1, IgG2, IgG3, IgG4) six was compared that 10 control...
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping an additional 10,780 cases and 10,938 controls from Asia confirmed with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), overall risk, rs3817963 (6p21.3, BTNL2) which is...
A wide variety of systemic lesions have been seen in patients with autoimmune pancreatitis. The pulmonary involvement pancreatitis was analysed to clarify the clinicopathological features comparison sarcoidosis.Nineteen had and eight sarcoidosis. symptoms, laboratory data, chest computed tomography, Gallium-67 scintigraphy, function testing bronchoscopy findings, including histological IgG4-immunostaining IgG subclasses bronchoalveolar lavage pancreatitis, were collected compare them...
Thymic carcinoma (TC) is a rare cancer whose genomic features have been examined in only limited number of patients European descent. Here, we characterized both and epigenomic aberrations by whole exome sequencing, RNA methylation array copy analyses TCs from Asian compared them with those USA/European patients. Samples analyzed were 10 pairs snap-frozen surgical specimens cancerous non-cancerous thymic tissue. All cases Japanese treated at the National Cancer Center Hospital, Japan,...
Background: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is a recently described entity associating upper-lobe lower-lobe fibrosis. We sought to evaluate differences in function between CPFE patients with without airflow obstruction. Subjects methods: Thirty-one were divided into two groups according the presence or absence irreversible obstruction based on spirometry (forced expiratory volume 1 second/forced vital capacity <70% following inhalation β 2 -agonist) as...
Measures of seasonal influenza control are generally divided into two categories: pharmaceutical and non-pharmaceutical interventions. The effectiveness these measures remains unclear, because insufficient study sample size and/or differences in settings. This observational epidemiological involved all elementary schoolchildren Matsumoto City, Japan, with during the 2014/2015 season. Questionnaires, including experiences diagnosis socio-demographic factors, were distributed to 29 public...