A5019559082- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Eosinophilic Esophagitis
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Veterinary medicine and infectious diseases
- Lymphoma Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Digestive system and related health
- IgG4-Related and Inflammatory Diseases
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Carbohydrate Chemistry and Synthesis
- Colorectal and Anal Carcinomas
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Salivary Gland Tumors Diagnosis and Treatment
Shinshu University
2016-2025
Ōtani University
1995-2024
Shinshu University Hospital
1996-2020
Yokohama City University
2012-2018
Yokohama City University Medical Center
2018
Shinonoi General Hospital
2018
Matsumoto City Hospital
2012-2015
Iwate Medical University
2014
RMIT University
2003-2014
Ibaraki Prefectural Central Hospital
2012
Since "Helicobacter pylori (H. pylori) infection" was set as the indication in Japanese Society for Helicobacter Research (JSHR) Guidelines 2009, eradication treatment H. gastritis is covered under insurance since 2013 Japan, and number of has rapidly increased. Under such circumstances, JSHR made third revision to "Guidelines diagnosis first time 7 years.The Guideline Committee held 10 meetings. Articles published between establishment 2009 March 2016 were reviewed classified according...
Histochemical analysis of the surface mucous gel layer human colon is difficult, as it dissolves in fixatives. This study was undertaken to explore on normal mucosa and neoplastic tissues large intestine. In addition, distribution different mucins secreted from goblet cells studied with a series histochemical stains for mucins.Twenty four surgically resected specimens were fixed Carnoy's solution embedded paraffin. cases, also frozen sections. Serial sections stained by battery techniques...
Abstract BACKGROUND Multifocal atrophic gastritis (MAG) is currently considered a precancerous lesion leading to intestinal type gastric carcinoma. The current study aimed describe the topography of atrophy in stomachs with early METHODS Resected from patients carcinoma were routinely processed, sectioned (an average 108 sections/stomach), and stained triple stain. Sections scored on visual analog scale for Heliobacter pylori metaplasia. epithelium (antral, oxyntic, transitional) was...
Studies of the pattern change in epidemiology Helicobacter pylori infection are scarce. A longitudinal cohort study consisted 644 children and adults, two independent cross-sectional surveys were conducted rural Japan between 1986 1994. The anti-H. IgG seroconver sion rates 1.1% 1% per year for respectively. seroreversion rate was 1.8% 1.5% adults. confirmed by studies. H. prevalence fell all age groups both (odds ratio [OR] = 0.5, 95% confidence interval [CI] 0.2–1.0, P .05) adults (OR 0.4,...
To obtain a tool to study the structural characterization and detection of mucin derived from gastric gland mucous cells, we developed monoclonal antibody, designated HIK1083, against purified rat mucosa. In an ELISA, HIK1083 reacted strongly with deep layer corpus antrum but only slightly that obtained surface mucosal layer. The reaction was inhibited by oligosaccharides alkaline borohydride reduction antigenic mucin. Two oligosaccharide alditols reacting antibody had one two peripheral...
Abstract Intake of salt and salty food is known as a risk factor for gastric carcinogenesis. To examine the dose‐dependence mechanisms underlying enhancing effects, Mongolian gerbils were treated with N ‐methyl‐ ‐nitrosourea (MNU), Helicobacter pylori containing various concentrations salt, sacrificed after 50 weeks. Among MNU H. , incidences glandular stomach cancers 15% in normal diet group 33%, 36% 63% 2.5%, 5% 10% NaCl groups, showing dose‐dependent increase ( p < 0.01). Intermittent...
Autoimmune pancreatitis (AIP) has been recently proposed as a disease entity, and an elevated serum IgG4 level is characteristic finding in it. This sometimes associated with other inflammatory diseases, such retroperitoneal fibrosis sclerosing cholangitis. To elucidate the clinicopathological characteristics of AIP‐associated prostatitis (AIP‐P), findings AIP‐P patients were evaluated, immunohistochemical expression IgG subclasses (IgG1, IgG2, IgG3, IgG4) six was compared that 10 control...
Background The relationship between bile acid reflux into the stomach and risk of atrophic gastritis intestinal metaplasia is still not well understood. Towards obtaining a better understanding, concentrations acids were measured. Patients Methods This study was carried out with participation 14 facilities in J apan, 2283 samples collected. subjects equal to or higher than limit detection divided four groups size (group A : 0–25%, group B 26–50%, C 51–75%, D 76–100%). Thus, including control...
ABSTRACT Lactobacillus acidophilus group bacteria (L. acidophilus, L crispatus, L. amylovorus, gallinarum, gasseri, johnsonii) , probiotic lactic acid bacteria, were applied to meat fermentation. Of six strains, gasseri (predominant lacto‐bacilli in human intestinal tracts) JCM1131 T exhibited greatest fermentation performance meats. This strain resisted gastric and bile, would thus have no detrimental effects the tract. Inoculation of depressed propagation S. aureus cells their enterotoxin...
Abstract Background: Helicobacter pylori ( H. ) is the major cause of chronic active gastritis and peptic ulcer disease. Recent studies have shown that produces various cytokines are related to neutrophil or mononuclear cell accumulation. Interleukin‐17 (IL‐17) founding member an emerging family inflammatory whose biological activities remain incompletely defined. In this study, contributions IL‐17 induction gastric inflammation protection from infection were investigated using gene‐knockout...
In preparation of the approval Helicobacter pylori therapy by Japanese national health system, board directors Society for Research decided to prepare guidelines on diagnosis and treatment H. infection physicians in routine medical practice.A committee was formed six meetings were held. Then, December 1999, a consensus meeting held Kobe obtain opinions general practitioners as well experts from Europe, North America, Asia.Helicobacter eradication is recommended gastric or duodenal ulcer...
Autoimmune pancreatitis (AIP) is a recently proposed disease entity, in which an elevated serum IgG4 characteristic. This sometimes associated with other inflammatory diseases: Sjögren's disease, or sclerosing cholangitis. The aim of the present paper was to examine difference pathophysiology between AIP‐associated cholangitis (AIP‐SC) and primary (PSC). clinicopathological findings immunohistochemical expressions IgG subclasses (IgG1, IgG2, IgG3, IgG4) were evaluated for two aforementioned...