A5033302261- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gastrointestinal motility and disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Esophageal Cancer Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Potassium and Related Disorders
- Diabetes Treatment and Management
- Genetic factors in colorectal cancer
- Pharmacogenetics and Drug Metabolism
- Cytomegalovirus and herpesvirus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune Response and Inflammation
Hamamatsu University School of Medicine
2016-2025
Weatherford College
2007-2024
Center for Clinical Research (United States)
2009-2023
Hamamatsu University Hospital
2023
Jikei University School of Medicine
2020
The Japanese Society of Gastroenterological Surgery
2020
Showa University
2020
Showa University Koto Toyosu Hospital
2020
Yamaguchi University
2019
Shiga University of Medical Science Hospital
2016
DNA double-strand breaks originating from diverse causes in eukaryotic cells are accompanied by the formation of phosphorylated H2AX (γH2AX) foci. Here we show that γH2AX is also a cellular response to topoisomerase I cleavage complexes known induce during replication. In HCT116 human carcinoma exposed inhibitor camptothecin, resulting can be prevented with phosphatidylinositol 3-OH kinase-related kinase wortmannin; however, contrast ionizing radiation, only camptothecin-induced replication...
Since "Helicobacter pylori (H. pylori) infection" was set as the indication in Japanese Society for Helicobacter Research (JSHR) Guidelines 2009, eradication treatment H. gastritis is covered under insurance since 2013 Japan, and number of has rapidly increased. Under such circumstances, JSHR made third revision to "Guidelines diagnosis first time 7 years.The Guideline Committee held 10 meetings. Articles published between establishment 2009 March 2016 were reviewed classified according...
Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and prevention of many conditions, including gastroesophageal reflux disease, gastric duodenal ulcers, erosive esophagitis, Helicobacter pylori infection, pathological hypersecretory conditions. Most PPIs metabolized primarily by cytochrome P450 2C19 (CYP2C19) into inactive metabolites, CYP2C19 genotype has been linked to PPI exposure, efficacy, adverse effects. We summarize evidence from literature provide...
Summary Background Acid inhibitory effects of proton pump inhibitors ( PPI s) are influenced by CYP 2C19 genotype. In contrast, the potent acid inhibition vonoprazan is not Aim To compare and esomeprazole in relation to Methods Twenty‐eight healthy Japanese volunteers [7 poor metabolisers PM s), 11 intermediate IM 10 rapid RM s)] received four different regimens a randomised crossover manner: (i) 20 mg twice daily (b.d.), (ii) daily, (iii) b.d. (iv) daily. The timing each dosing was 1 h...
Background Precision cancer risk stratification for gastric is urgently needed the growing number of healthy people after Helicobacter pylori eradication. The epimutation burden in non-malignant tissues has been associated with multiple cross-sectional studies. Objective To confirm clinical usefulness a DNA methylation marker burden, and to identify cut-off level super-high-risk population. Design Healthy H. eradication open-type atrophy were prospectively recruited. levels gene, RIMS1 ,...
Background: Omeprazole is metabolized by S-mephenytoin 4′-hydroxylase (CYP2C19) in the liver. In persons with a poor-metabolizer genotype for CYP2C19, therapeutic efficacy of omeprazole may be increased. Objective: To investigate whether CYP2C19 status associated cure rates Helicobacter pylori infection and peptic ulcer achieved using dual therapy amoxicillin. Design: Prospective cohort study. Setting: University hospital health service center Hamamatsu, Japan. Patients: 62 patients H....
Objective Omeprazole is metabolized by genetically determined S-mephenytoin 4′-hydroxylase (CYP2C19) in the liver. This study aimed to determine whether effect of omeprazole on intragastric pH depends CYP2C19 genotype status. Methods status for 2 mutations associated with poor metabolizer phenotype was a polymerase chain reaction–restriction fragment length polymorphism method 16 healthy volunteers. Helicobacter pylori serology and [13C]urea breath test. After single oral administration 20...
Background Proton pump inhibitors such as omeprazole and lansoprazole are mainly metabolized by CYP2C19 in the liver. The therapeutic effects of proton assumed to depend on genotype status. Objective We investigated whether status was related eradication rates H pylori triple inhibitor–clarithromycin–amoxicillin (INN, amoxicilline) therapy attempted establish a strategy for treatment after failure eradicate pylori. Methods A total 261 patients infected with completed initial 20 mg or 30...
Background: Omeprazole is mainly metabolized in the liver by CYP2C19, a genetically determined enzyme, whereas rabeprazole reduced non‐enzymatically and partially CYP2C19. The therapeutic effects of are therefore assumed to be less affected an individual’s CYP2C19 status. Aim: To investigate acid inhibitory plasma levels omeprazole with reference different genotypes. Methods: Fifteen healthy volunteers took daily dose 20 mg or for 8 days. On post‐dose days 1 8, 24‐h profiles intragastric pH...
Helicobacter pylori eradication rates by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin at standard doses depend on bacterial susceptibility to patient CYP2C19 genotypes. We examined the usefulness of personalized for H. infection based these factors as determined genetic testing. First, optimal lansoprazole dosing schedules that would achieve sufficient acid inhibition allow in each different genotype groups were 24-h intragastric pH monitoring. Next, 300...
Background Recent in-vitro studies have suggested that mast cells are involved in Dengue virus infection. To clarify the role of development clinical fever, we compared plasma levels several cell-derived mediators (vascular endothelial cell growth factor [VEGF], soluble VEGF receptors [sVEGFRs], tryptase, and chymase) -related cytokines (IL-4, -9, -17) between patients with differing severity fever healthy controls. Methodology/Principal Findings The study was performed at Children's...
Backgrounds/Aims: Vonoprazan (VPZ) is the first clinically available potassium competitive acid blocker. This class of agents provides faster and more potent inhibition than proton pump inhibitors. Most strains Helicobacter pylori are sensitive to amoxicillin. We hypothesized that dual therapy with VPZ amoxicillin would provide sufficient eradication rate for H. infection. To evaluate this, we compared by VPZ/amoxicillin standard triple VPZ/amoxicillin/clarithromycin therapy. Methods:...
Objective The Kyoto gastritis classification categorizes the endoscopic characteristics of Helicobacter pylori (H. pylori) infection-associated and identifies patterns associated with a high risk gastric cancer. We investigated its efficacy, comparing scores in patients H. pylori-associated Methods A total 1,200 pylori-positive alone (n=932), early-stage cancer (n=189), successfully treated pylori-negative (n=79) were endoscopically graded according to for atrophy, intestinal metaplasia,...
Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal reduced the severity experimental colitis in mice. However, is still unclear whether possess same ability to be polarized cells with different phenotypes cytokine production patterns as bone-marrow-derived To address this question, we examined determined specific profiles each phenotype. We showed...
In Japan, the prevalence of autoimmune gastritis (AIG) is assumed to be very low. With recent rapid decrease in Helicobacter pylori (Hp) prevalence, reports on AIG are increasing. This multicenter registry study aimed clarify characteristics AIG, especially its endoscopic appearance.A total 245 patients with from 11 institutions Japan January 2010 October 2016 were included, and their clinical findings evaluated.Mean age was 67.2 ± 11.4 years, 63.7% participants women. The most common...
The Japanese diagnostic criteria for autoimmune gastritis (AIG) were established by the "Study Group on establishment of type A gastritis," which is related to a workshop associated with Japan Gastroenterological Endoscopy Society (JGES) and Committee AIG Research (CARP). set as follows: cases confirmed diagnosis are patients in whom either endoscopic or histological findings, both, meet requirements who be positive gastric autoantibodies (either anti-parietal cell anti-intrinsic factor...