Background —The circulating levels of secretory nonpancreatic type II phospholipase A 2 (sPLA ) are increased in various chronic inflammatory diseases and the increase correlates with disease severity. sPLA may possibly play a role atherogenesis is highly expressed atherosclerotic arterial walls that known to have features. Thus, this study prospectively examined whether significant risk prognostic values patients coronary artery (CAD). Methods Results —Plasma were measured 142 CAD 93...

Background: Omeprazole is mainly metabolized in the liver by CYP2C19, a genetically determined enzyme, whereas rabeprazole reduced non‐enzymatically and partially CYP2C19. The therapeutic effects of are therefore assumed to be less affected an individual’s CYP2C19 status. Aim: To investigate acid inhibitory plasma levels omeprazole with reference different genotypes. Methods: Fifteen healthy volunteers took daily dose 20 mg or for 8 days. On post‐dose days 1 8, 24‐h profiles intragastric pH...

Abstract Dehydroepiandrosterone sulfate (DHEAS) is the major secretory steroid of human adrenal glands. The secretion DHEAS decreases with aging. incidence heart failure also rises in elderly population. We measured plasma levels and cortisol 49 patients chronic (CHF) 32 age-matched controls assessed its relation to A-type natriuretic peptide B-type peptide, biochemical markers failure. Plasma were significantly lower CHF than controls, whereas there was no significant difference between two...

Cigarette smoking impairs endothelial function and is one of the major risk factors for atherosclerosis coronary heart disease. Insulin resistance associated with atherosclerosis. We examined effects vitamin C on insulin sensitivity by measuring steady-state plasma glucose (SSPG) flow-mediated dilation (FMD) brachial artery. studied 16 current smokers normal tolerance, 15 nonsmokers impaired tolerance (IGT), 17 as controls. Both SSPG FMD were blunted in IGT compared In smokers, decreased ( P...

Background The purpose of this study was to investigate which 12 neuropsychological tests predict alcoholic patients’ alcohol‐specific and/or alcoholic‐nonspecific outcome. Our hypothesis that the ecologically valid measure executive function are better predictors alcoholics’ functional Methods We administered chronic alcoholics. Included in were tasks Reaction Time, Symbol Digit Modalities, Figure Position, Span, Block Design, Trail Making, and six subtests a battery called Behavioral...

Summary Statins are cholesterol‐lowering drugs that have been reported to promote bone formation. The purpose of this study was investigate the effect simvastatin on enhancement formation around titanium implants. Thirty‐week‐old female rats received pure implants in both tibiae. animals were intra‐peritoneally administered 0, 0·125, 1, 5 or 10 mg kg −1 daily. After 30 days, sacrificed, and specimens prepared. contact ratio implant, density medullary canal percentage cortical obtained....

<p>Paracellular 45Ca absorption and temporal systolic blood pressure (SBP) measurements were recorded in spontaneously hypertensive (SHR) normotensive Wistar-Kyoto (WKY) rats fed on casein (C) soya-bean-protein isolate (S) diets, containing 20 (H), 5 (H) 0.5 (L) g Ca/kg. Similar also taken SHR only C-M S-M diets supplemented with 30 caseinophosphopeptides (CPP)/kg. Absorption of from the ileal loop was equivalent both WKY animals largely affected by level dietary Ca. In addition, C...

Background: Self-disturbances in schizophrenia have begun to be explained by an abnormality the sense of agency (SoA). The cerebral structures SoA healthy people are considered mainly include insula and inferior parietal lobule. In contrast, functional lesion aberrant is not yet fully understood. Considering recent explanation establishing from standpoint associative learning, "agency network" may only lobule but also striatum. We hypothesized that based on a deficit network". Methods:...

Abstract Clinicopathological issues regarding so‐called ‘alcoholic dementia’ remain under debate. Although clinical observation favors the diagnosis of primary alcohol dementia, caused by direct neurotoxicity, further confirmation from neuropathological and biochemical perspectives is warranted. Repeat episodes subclinical Wernicke–Korsakoff’s syndrome may partially account for chronic state alcoholic thus supporting notion that dementia exists in continuum with types syndrome. Diagnostic...

A family history of alcoholism has been demonstrated to be an important factor affecting cognitive function. However, no studies have yet conducted compare recovery history-positive (FH+) and history-negative (FH-) alcoholics in the subacute withdrawal period. To tackle this problem, a neuropsychological test battery consisting six computerized tests was administered 19 FH+ 20 FH- at 2 7 weeks after abstinence. At abstinence, overall performance both groups significantly poorer than that...

Seven cases of myelodysplastic syndrome with myelofibrosis, which is defined using the following criteria: (1) pancytopenia less than 5% blasts in peripheral blood; (2) minimal or no splenomegaly; (3) myelofibrosis cellular marrow; (4) absence diffuse proliferation bone and (5) presence features marrow blood cells, are presented. They were range 52-82 years old consisted 3 males 4 females. Six out 7 developed into acute leukaemia after 5 to 8 months from onset died between 2 weeks evolution...

The plasma concentration of monocyte chemoattractant protein-1 (MCP-1) antigen is higher in patients with restenosis after coronary angioplasty than those who do not restenose. In this study the MCP-1 expression atherectomy specimens was investigated by immunohistochemistry. Samples were obtained from 12 and 15 de novo lesions directional atherectomy. immunoreactivity found all group 8 group. frequency macrophage These results indicate that local may be associated mechanisms vascular...

AbstractBACKGROUND. Plasminogen activator inhibitor (PAI) is a marker of recurrence myocardial infarction. Diabetes mellitus also an important risk factor coronary artery disease, including infarction and angina pectoris.AIM. We examined baseline plasma PAI activity levels, clinical variables, angiographic findings assessed them as prospective values for subsequent events, such sudden death, nonfatal revascularization by percutaneous transluminal angioplasty or bypass surgery during the...

Recent clinical trials have demonstrated that the administration of angiotensin-converting enzyme (ACE) inhibitors to patients with myocardial infarction reduces incidence recurrent infarction. It has also been reported an elevated level plasminogen activator inhibitor (PAI) appears constitute a marker risk coronary thrombosis. To determine whether ACE captopril plasma PAI activity, we measured changes in activity (IU/ml), tissue (t-PA) antigen (ng/ml), and serum (IU/L) 14 survivors...

Thrombus in the infarct-related artery is one of limitations for flow restoration primary percutaneous transluminal coronary angioplasty (PTCA) treatment acute myocardial infarction (AMI). The present study investigated benefit preceding intracoronary thrombolysis (ICT) by retrospectively analyzing phase 80 AMI patients with thrombus: 40 undergoing PTCA alone (primary group) and treated ICT plus (combined group). Acute Thrombolysis Myocardial Infarction (TIMI) grade was as follows: TIMI 0/1:...

The Obsessive-Compulsive Drinking Scale (OCDS) is a self-rating questionnaire that measures cognitive and behavioral aspects of craving for alcohol. OCDS consists two subscales: the obsessive thoughts drinking subscale (OS) compulsive (CS). This study aims to validate Japanese version OCDS. First, internal consistency discriminant validity were evaluated. Second, prospective longitudinal 3-month outcome 67 patients with alcohol dependence who participated in relapse prevention program was...

A 68-year-old woman with schizophrenia after a cerebrovascular accident resulting in right medial temporal and occipital damage developed Frégoli syndrome. Neuropsychological testing revealed that she had impairment facial recognition compatible prosopagnosia. The syndrome disappeared three month when, remarkably, her prosopagnosia also disappeared. Our findings are consistent the hypothesis combination of hyperactivations temporo-limbic connection frontal dysfunction may account for development

The Japanese version of the Rapid Dementia Screening Test (RDST-J) and clock-drawing test (CDT) are both brief psychometric screening tools used to detect severity Alzheimer's disease. It remains unclear, however, which is more effective when for mild disease.We administered RDST-J CDT 250 patients with very severe disease 49 healthy volunteers. Patients a Mini-Mental State Examination score 12-26 had Clinical Rating (CDR) scores from 0.5 3. were divided into four groups according CDR score....

It has been reported that coronary endothelial dysfunction is associated with the pathogenesis of spasm, and nitric oxide (NO) mediated vasodilatation was decreased in epicardial arteries patients spastic angina (CSA). However, there are few reports about function peripheral resistance vessels CSA, so present study investigated role NO forearm such patients. The responses blood flow to acetylcholine (ACh; 8-24 μg/min) sodium nitroprusside (SNP; 0.4-1.2 μg/ml) infusions examined using...

Two experiments were carried out to examine memory in persons with amnesia using self-performed tasks. In Experiment 1, Korsakoff's syndrome and nonamnesic participants alcoholism learned action phrases not involving real objects by either tasks or verbal As indexed free recall recognition tests, a advantage favoring was confirmed both participant groups. 2, syndrome, alcoholic participants, young control object names under three different study conditions that differed from one another as...