A5015782642- Pharmacogenetics and Drug Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Glutathione Transferases and Polymorphisms
- Liver Disease Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Inflammatory mediators and NSAID effects
- Venous Thromboembolism Diagnosis and Management
- Helicobacter pylori-related gastroenterology studies
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Gastroesophageal reflux and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pharmacological Effects of Natural Compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Neuroendocrine Tumor Research Advances
- Asthma and respiratory diseases
Kumamoto University
2008-2017
PharmacoGenetics (China)
2012-2013
Yokohama City University Medical Center
2013
Yokohama City University
2013
Yamaguchi University Hospital
2013
Kumamoto Health Science University
2009
Roche (Switzerland)
2008
Kumamoto Medical Center
2006
Kyoto Prefectural Institute of Public Health and Environment
2004-2005
Kaneka (Japan)
2005
Background: Omeprazole is mainly metabolized in the liver by CYP2C19, a genetically determined enzyme, whereas rabeprazole reduced non‐enzymatically and partially CYP2C19. The therapeutic effects of are therefore assumed to be less affected an individual’s CYP2C19 status. Aim: To investigate acid inhibitory plasma levels omeprazole with reference different genotypes. Methods: Fifteen healthy volunteers took daily dose 20 mg or for 8 days. On post‐dose days 1 8, 24‐h profiles intragastric pH...
Objectives: The efflux transporter P-glycoprotein encoded by the ATP-binding cassette (ABC)B1 gene may play a role in drug-resistant epilepsy limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs). Our objective was to investigate effect ABCB1 polymorphisms on AED responsiveness pharmacokinetics carbamazepine (CBZ) epileptic patients with indication for CBZ therapy. Methods: T-129C, C1236T, G2677T/A C3435T were genotyped 210 Japanese epileptics who had been...
Rabeprazole is a potent proton pump inhibitor and mainly reduced to thioether rabeprazole by non-enzymatic pathway partially metabolized demethylated CYP2C19 in the liver. We intended determine cure rate for Helicobacter pyloriinfection dual rabeprazole/amoxicillin therapy relation genotype status prospectively. Ninety-seven patients with gastritis andH. pylori infection completed 10 mg of bid 500 amoxicillin tid 2 weeks. At 1 month after treatment, H. was assessed on basis histology, rapid...
To establish whether the SCN1A IVS5-91 G > A polymorphism of gene, which encodes neuronal sodium channel alpha subunit, affects responsiveness to antiepileptic drugs (AEDS) carbamazepine and/or phenytoin.SCN1A was genotyped in 228 Japanese epileptic patients treated with AEDs. The association between AED and estimated by logistic regression analysis, adjusting for clinical factors affecting outcome therapy.The frequency AA genotype significantly higher carbamazepine-resistant (odds ratio,...
In normal weight subjects (body mass index < 25 kg/m2), non-alcoholic fatty liver disease (NAFLD) is likely to coexist with metabolic diseases. The patatin-like phospholipase 3 (PNPLA3) polymorphism rs738409 (c.444C>G) associated the risk of NAFLD and/or renal dysfunction; however, influence status on associations remains unknown. We aimed clarify PNPLA3 dysfunction, while also paying careful attention subjects. Cross-sectional and retrospective longitudinal studies 5.5 ± 1.1 years follow-up...
The aim of this study is to verify whether the combination glutathione S-transferase (GST) M1 null and GSTT1 genotypes, which a candidate genetic risk factor for troglitazone-induced liver failure, common that carbamazepine-induced mild hepatotoxicity. Patients & methods: genotypes GSTM1 GSTT1, microsomal epoxide hydrolase-3 -4, were determined in 192 Japanese epileptics treated with carbamazepine. Results: (GSTM1-) (GSTT1-) subjects 55.7 39.6%, respectively. alanine aminotransferase (ALT)...
Background: Clobazam (CLB) is a 1,5-benzodiazepine with antiepileptic properties. More than 70% of administered CLB dealkylated to yield N-desmethylclobazam (N-CLB), pharmacologically active metabolite, by cytochrome P450 (CYP) 3A4 and CYP2C19. The subsequent inactivation N-CLB primarily catalyzed Meanwhile, oxidoreductase (POR) the obligatory electron donor all microsomal CYP enzymes. aim this study was evaluate impact CYP2C19 POR genotypes on pharmacokinetic parameters N-CLB. Methods: This...
Cytochrome P450 (CYP) 2C19 plays a role in the biotransformation of clinically relevant drugs as well endogenous compounds, including sex hormones, which are known to be modulators food intake and energy balance humans. We attempted investigate influence CYP2C19 polymorphisms on valproic acid (VPA)-induced weight gain.This retrospective longitudinal study included 85 VPA-treated 93 carbamazepine (CBZ)-treated (as reference) young patients with epilepsy. The body mass index (BMI) gap between...
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent up to 40% of the East Asians and reported be associated with acute myocardial infarction (AMI). To elucidate mechanisms underlying association AMI, we compared clinical features AMI patients those wild-type ALDH2*1/*1.The study subjects consisted 202 Japanese ST-segment elevation (STEMI) (156 men 46 women; mean age, 67.3±12.0) who underwent primary...
Aims . We aimed to investigate the sex differences in renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on risk factors at early stage of dysfunction. Methods A clinic-based retrospective longitudinal study (follow-up duration:<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn mathvariant="normal">8.1</mml:mn><mml:mo>±</mml:mo><mml:mn mathvariant="normal">1.4</mml:mn></mml:math>years) was conducted assess annual estimated glomerular...
One of seven poor metabolizers coumarin found in Thai subjects was previously genotyped as heterozygote for the CYP2A6*4 (whole deletion) and CYP2A6*9. Thus, we aimed to investigate relationship between genetic polymorphism TATA box CYP2A6 gene (CYP2A6*9), expression levels mRNA 7-hydroxylase activities human livers. Levels were quantified by real-time quantitative reverse transcriptase-polymerase chain reaction. The mean individuals with CYP2A6*1/*4, CYP2A6*1/*9 CYP2A6*4/*9 58%, 71% 21%...
A nonlinear mixed-effect modeling (NONMEM) program was used to evaluate the effects of cytochrome P450 (CYP) 2C9 and CYP2C19 polymorphisms on phenobarbital (PB) population clearance for Japanese epileptics. The pharmacokinetics 260 PB concentrations at a steady-state obtained from 79 patients described with one-compartment open pharmacokinetic model first-order elimination. covariates screened included total body weight (BW), age, gender, daily dose, CYP2C9 genotypes, coadministered...
Introduction: Diabetes mellitus is associated with an increased production of reactive oxygen species and a reduction in antioxidant defenses. The aim this study to determine the association between incidence Type 2 diabetes gene polymorphisms glutathione S-transferase (GST), which modulates oxidative stress. Materials & Methods: associations GSTT1 GSTM1 genotypes were analyzed 469 Japanese participants health-screening program. Results: clinical characteristics smoking status obtained from...
Cytochromes P450 (P450) involved in letrozole metabolism were investigated. Among 13 recombinant forms examined, only 2A6 and 3A4 showed activities transforming to its carbinol metabolite with small K(m) high Vmax values yielding apparent Vmax/K(m) of 0.48 0.24 nl min(-1) nmol(-1) P450, respectively. The metabolic individual human liver microsomes a significant correlation coumarin 7-hydroxylase (P450 marker) at concentration 0.5 microM, while good was also seen testosterone...
Background: Clobazam-induced adverse reactions have been reported in cases with CYP2C19 defective allele(s). However, the relevance of genotypes to clobazam therapy remains be clarified. Methods: The association between and antiepileptic effects was retrospectively investigated 110 Japanese subjects, relation N-desmethylclobazam (N-clobazam) concentrations. Results: There were 41 (37.3%) homozygous extensive metabolizers (EMs), 44 (40.0%) heterozygous EMs, 25 (22.7%) poor (PMs). response...
Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for treatment epileptic seizures. Although it well known that doses VPA and its plasma concentrations are highly correlated, do not correlate with therapeutic effects VPA. In this study, we developed a population-based pharmacokinetic (PK)-pharmacodynamic (PD) model to determine optimal concentration according clinical characteristics each patient. This retrospective study included 77 VPA-treated Japanese patients...
AbstractUsing a newly developed real-time reverse transcriptase-polymerase chain reaction method, mRNAs were quantitated for CYP3A4, CYP3A5 and CYP3A7 in adult livers from 24 Japanese Caucasian subjects to elucidate the potential ethnic differences expression levels of human cytochrome P450 (CYP) 3As. The level CYP3A4 mRNA (n = 24) was approximately three times higher than that 24, p < 0.001). mean twice 9) Caucasians 5) heterozygous *1 allele (p 0.057). 22) carrying *1A/ *1A genotype...