A5089939695- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Obesity, Physical Activity, Diet
- Health disparities and outcomes
- Blood Pressure and Hypertension Studies
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Pregnancy and Medication Impact
- Child and Adolescent Psychosocial and Emotional Development
- Disaster Response and Management
- Smoking Behavior and Cessation
- Sodium Intake and Health
- Prenatal Substance Exposure Effects
- Genomics and Rare Diseases
- Tea Polyphenols and Effects
- Breastfeeding Practices and Influences
- Nutrition and Health in Aging
- Cancer Risks and Factors
- Assisted Reproductive Technology and Twin Pregnancy
- Folate and B Vitamins Research
- Autism Spectrum Disorder Research
- Nutrition, Genetics, and Disease
Tohoku Medical Megabank Organization
2016-2025
Tohoku University
2016-2025
National Research Institute of Fire and Disaster
2015-2024
National Research Institute for Earth Science and Disaster Resilience
2023
Tohoku University Hospital
2018
Second Xiangya Hospital of Central South University
2016
Central South University
2016
National Cancer Centre Japan
2016
Food and Drug Administration
2016
Tohoku Fukushi University
2016
Most studies that have evaluated the association between body-mass index (BMI) and risks of death from any cause specific causes been conducted in populations European origin.We performed pooled analyses to evaluate BMI risk among more than 1.1 million persons recruited 19 cohorts Asia. The included approximately 120,700 deaths occurred during a mean follow-up period 9.2 years. Cox regression models were used adjust for confounding factors.In East Asians, including Chinese, Japanese,...
Abstract The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070 healthy Japanese individuals and construction a population reference panel (1KJPN). Here we identify through this high-coverage sequencing (32.4 × on average), 21.2 million, including 12 million novel, single-nucleotide variants (SNVs) at an estimated false discovery rate <1.0%. This detailed analysis detected signatures for purifying selection regulatory elements as well coding regions. We also...
Background The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly Asia, as the prevalence overweight obesity; European-derived populations, obesity are established causes diabetes. shape association with risk its overall impact have not been adequately studied Asia. Methods Findings A pooled cross-sectional analysis was conducted to evaluate between baseline body mass index (BMI, measured weight kg divided by square height m) self-reported status...
Although ecological observations suggest that the Japanese diet may reduce risk of cardiovascular disease (CVD), impact a dietary pattern upon mortality due to CVD is unclear.We prospectively assessed association between patterns among and mortality. Dietary information was collected from 40 547 men women aged 40-79 years without history diabetes, stroke, myocardial infarction or cancer at baseline in 1994.During 7 follow-up, 801 participants died CVD. Factor analysis (principal component)...
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
The first step towards realizing personalized healthcare is to catalog the genetic variations in a population. Since dissemination of individual-level genomic information strictly controlled, it will be useful construct population-level allele frequency panels with easy-to-use interfaces. In Tohoku Medical Megabank Project, we sequenced nearly 4000 individuals from Japanese population and constructed an panel 3552 after removing related samples. called 3.5KJPNv2. It was by using standard...
Whether some domains of child development are specifically associated with screen time and whether the association continues age remain unknown.To examine between exposure among children aged 1 year 5 developmental delay (communication, gross motor, fine problem-solving, personal social skills) at 2 4 years.This cohort study was conducted under Tohoku Medical Megabank Project Birth Three-Generation Cohort Study. Pregnant women 50 obstetric clinics hospitals in Miyagi Iwate prefectures Japan...
Summary Background Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative is needed patients intolerant or resistant to thiopurines. Aim To evaluate the effectiveness of home enteral nutrition as regimen which half daily calorie requirement provided by elemental diet and remaining free diet. We refer this ‘half diet’. Methods Between 2002 2005, 51 remission from two hospitals were randomly assigned group ( n = 26) 25). The primary outcome measure...
Abstract We conducted a population‐based prospective cohort study in Japan to examine the relationship between body mass index (BMI) and risk of incidence any cancer at individual sites. Body was calculated from self‐administered weight height baseline. Relative risks (RR) 95% confidence intervals (CI) were multivariate proportional‐hazards models. Among 27,539 persons (15,054 women 12,485 men) aged 40 years or older who free enrollment 1984, 1,672 (668 1,004 developed during 9 follow‐up. In...
In a prospective study of prostate cancer incidence (127 cases), among 22 320 Japanese men, sleep duration was associated with lower risk; the multivariate hazard ratio men who slept ⩾9 h per day compared those less 0.48 (95% confidence interval: 0.29–0.79, P for trend=0.02).
Objective: The aim of this study is to evaluate the validity and utility Japanese version WHO-Five Well-Being Index (WHO-5-J) in context detecting suicidal ideation elderly community residents.Methods: A sample 696 subjects aged 70 years or over who completed a set questionnaires was examined.Results: Cronbach's α 0.87 Loevinger's coefficient 0.64. total score significantly correlated with number cohabitants, physical illnesses, functioning, instrumental activities daily living, depressive...
Helicobacter pylori eradication rates by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin at standard doses depend on bacterial susceptibility to patient CYP2C19 genotypes. We examined the usefulness of personalized for H. infection based these factors as determined genetic testing. First, optimal lansoprazole dosing schedules that would achieve sufficient acid inhibition allow in each different genotype groups were 24-h intragastric pH monitoring. Next, 300...
In a prospective study of 23 995 Japanese women, short sleep duration was associated with higher risk breast cancer (143 cases), compared women who slept 7 h per day, the multivariate hazard ratio those ⩽6 day 1.62 (95% confidence interval: 1.05–2.50; P for trend=0.03).
Objectives: A nationwide epidemiological survey was conducted to estimate the number of patients treated for acute pancreatitis (AP) in 2007 Japan and clarify clinicoepidemiological features AP. Methods: In first survey, a simple questionnaire used inquire about with AP who visited hospital year 2007. This directly mailed heads 3027 facilities. The second forwarded those facilities from which were reported on questionnaire. Results: estimated total 57,560 (95% confidence interval,...
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines Management Hypertension. However, large-scale studies on association smoking, potassium excretion, and gamma-glutamyl transferase level with BP population are limited. We conducted a cross-sectional study to examine between risk systolic blood pressure Tohoku Medical Megabank Community-based Cohort Study (23,446 men 38,921 women aged ≥20 years). A model adjusted age, body mass...
ABSTRACT Aims This study investigated the association between maternal age and early late gestational diabetes mellitus (GDM). Methods In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations GDM (diagnosed at <24 weeks) ≥24 evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was of 30–34.9 years. Results Higher associated higher odds ( P ‐value for trend <0.0001 <0.0001,...
Abstract The objective of the present study was to evaluate association between suicidal ideation and potentially related factors in an elderly urban Japanese population. This a community‐based, cross‐sectional study. Urban community residents aged 70 years or more were interviewed regarding sociodemographic health‐related variables. Subjects with depressive symptoms underwent further evaluation by psychiatrists using criteria Diagnostic Statistical Manual Mental Disorders, 4th edition....