Teiji Tominaga
A5090356821- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Epilepsy research and treatment
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and genetic disorders
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Testicular diseases and treatments
- RNA modifications and cancer
Tohoku University
2016-2025
Tohoku University Hospital
2014-2024
Jikei University School of Medicine
2015-2024
Kohnan Hospital
2012-2023
Gifu Municipal Hospital
2023
Gifu University
2023
Nagoya University
2023
Sendai Medical Center
2013-2020
Tohoku Medical Megabank Organization
2016-2020
Teijin (Japan)
2015-2020
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique...
Background and Purpose— About one half of those who develop adult-onset moyamoya disease experience intracranial hemorrhage. Despite the extremely high frequency rebleeding attacks poor prognosis, measures to prevent have not been established. The purpose this study is determine whether extracranial–intracranial bypass can reduce incidence improve patient prognosis. Methods— This was a multicentered, prospective, randomized, controlled trial conducted by 22 institutes in Japan. Adult...
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, histologic variant. Stark prognostic genetic differences among the subgroups suggest that subgroup-specific biomarkers could improve prognostication.Molecular were identified from a discovery set 673 medulloblastomas 43 cities around world. Combined risk stratification models...
In this report, we, the Research Committee on Moyamoya Disease (Spontaneous Occlusion of circle Willis), describe in detail changes new "Diagnostic Criteria 2021" for moyamoya disease and its scientific basis to make it widely known world. The revised criteria cover all aspects disease, including a definition concept, diagnostic imaging, concept quasi-moyamoya (moyamoya syndrome).
Clazosentan has been investigated globally for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). The authors evaluated its effects on vasospasm-related morbidity and all-cause mortality following aSAH in Japanese patients.Two similar double-blind, placebo-controlled phase 3 studies were conducted 57 centers patients with aSAH, aneurysms secured by endovascular coiling one study surgical clipping other. In each study, randomly administered intravenous...
Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide range cancer cells and plays important roles progression metastasis. Recently, intracellular function TF has been revealed to be involved invasion, independent blood pathway. To evaluate clinical significance expression, we performed enzyme-linked immunosorbent assay (ELISA) plasma 67 breast patients immunohistochemistry 213 tissues. In ELISA study, showed up-regulation concentration compared with...
The authors created a simple, broadly applicable classification of saccular intracranial aneurysms into three categories: sidewall (SW), with branching vessel (SWBV), and endwall (EW) according to the angiographically documented patterns their parent arteries. Using computational flow dynamics analysis (CFDA) simple models representing aneurysm categories, analyzed geometry-related risk factors such as neck width, artery curvature, angulation vessels.The performed CFDAs 68 aneurysmal...
BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis prevents ischemic attack by improving blood flow in patients with occlusive cerebrovascular disease and hemodynamic compromise. Recent evidence suggests that focal hyperperfusion is a potential complication of this procedure for moyamoya disease. OBJECTIVE: To clarify the exact differences incidence clinical manifestations phenomenon between without METHODS: N-isopropyl-p-[123I]iodoamphetamine single-photon...
Cortical sensory maps can reorganize in the adult brain an experience-dependent manner. We monitored somatosensory cortical reorganization after deafferentation using functional magnetic resonance imaging (fMRI) rats subjected to complete transection of mid-thoracic spinal cord. representation response spared forelimb stimulation was observed enlarge and invade adjacent sensory-deprived hind limb territory primary cortex as early 3 days injury. Functional MRI also demonstrated long-term...
Object Young patients with moyamoya disease frequently exhibit extensive cerebral infarction at the time of initial presentation, and even in early postoperative period. To investigate clinical characteristics period, authors prospectively analyzed findings MR imaging, angiography, SPECT before after surgery. The focused particular on how neurological deterioration occurred. Methods Between August 2005 June 2009, 22 younger than 18 years age were treated Miyagi Children's Hospital. mean...