A5005297664- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Disaster Response and Management
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Gastrointestinal disorders and treatments
- Cancer-related Molecular Pathways
- Urinary Bladder and Prostate Research
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Gallbladder and Bile Duct Disorders
- Cancer Diagnosis and Treatment
- Disaster Management and Resilience
- Extracellular vesicles in disease
Tohoku University
2016-2025
Jikei University School of Medicine
2005-2024
Tohoku Medical Megabank Organization
2016-2021
Showa University
2021
Showa University Hospital
2021
Institute of Disaster Prevention
2021
Tohoku University Hospital
2009-2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
The Jikei University Hospital
2006-2018
Purpose The present phase III study was designed to investigate the noninferiority of S-1 alone and superiority gemcitabine plus compared with respect overall survival. Patients Methods participants were chemotherapy-naive patients locally advanced or metastatic pancreatic cancer. randomly assigned receive only (1,000 mg/m 2 on days 1, 8, 15 a 28-day cycle), (80, 100, 120 mg/d according body-surface area 1 through 28 42-day (gemcitabine 1,000 8 60, 80, 100 14 21-day cycle). Results In total...
This multicentre randomised phase III trial was designed to determine whether adjuvant chemotherapy with gemcitabine improves the outcomes of patients resected pancreatic cancer. Eligibility criteria included macroscopically curative resection invasive ductal carcinoma pancreas and no earlier radiation or chemotherapy. Patients were randomly assigned at a 1 : ratio either group surgery-only group. received dose 1000 mg m−2 over 30 min on days 1, 8 15, every 4 weeks for 3 cycles. Between...
The Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR) is the first global policy framework of United Nations' post-2015 agenda. It represents a step in direction coherence with explicit reference to health, development, and climate change. To develop SFDRR, Nations Office (UNISDR) organized facilitated several global, regional, national, intergovernmental negotiations technical meetings period preceding World Conference on (WCDRR) 2015 where SFDRR was adopted. UNISDR also worked...
Since 1981, the Japan Pancreas Society has been hosting a nationwide pancreatic cancer registry. To commemorate its 30th anniversary, we review history and latest achievement.During 3 decades, more than 350 leading institutions in contributed voluntarily to register periodic follow-up. The registry was modified protect privacy by encrypting hash algorithm.From 1981 2007, 32,619 cumulative records were analyzed. overall survival of invasive improved significantly. More patients with earlier...
Understanding normal and cancer stem cells may provide insight into the origin of new therapeutics for prostate cancer. Normal in have recently been identified with a CD44(+)/alpha(2)beta(1)(high)/CD133(+) phenotype. Stromal cell-derived factor-1 (SDF-1) its receptor, CXCR4, multiple essential functions, including homing metastasis cells. We show here that human telomerase reverse transcriptase (hTERT)-immortalized primary nonmalignant (RC-165N/hTERT) malignant (RC-92a/hTERT) tumor-derived...
<h3>Objective</h3> The clinicopathological significance of four morphological types intraductal papillary mucinous neoplasms the pancreas (IPMNs; gastric, intestinal, pancreatobiliary and oncocytic) was assessed. <h3>Design</h3> Retrospective multicentre analysis 283 surgically resected IPMNs. <h3>Results</h3> Of IPMNs, 139 were gastric type, 101 19 24 oncocytic. These significantly associated with factors including sex (p=0.0032), age (p=0.00924), ectatic duct size (p=0.0245), detection...
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
The feasibility of neoadjuvant chemoradiation therapy for cholangiocarcinoma, followed by conventional resection, has not been determined yet. Here, a phase I study therapy, named NACRAC, was performed to determine the maximum tolerated dose (MTD) and recommended (RD) gemcitabine when combined with external beam radiation resectable cholangiocarcinoma.From August 2007 June 2008, 12 patients provided informed consent. Preoperative administered in 1.8Gy daily fractions up total 45Gy....
The prognosis of pancreatic cancer is defined by the histology and extent disease. Preoperative histologic diagnosis diagnostic imaging are fundamentals in managing disease, but it not rare to find unexpected peritoneal dissemination or liver metastasis at time operation. overall resectability rate 40% Japan. Resecting portal vein peripancreatic plexus were performed on patients who underwent pancreatectomy for invasive head pancreas. Long-term survival was only found pancreatectomy. Radical...
Abstract AURKA/STK15/BTAK, the gene encoding Aurora A kinase that is involved in regulation of centrosomes and segregation chromosomes, frequently amplified overexpressed various kinds human cancers, including pancreatic cancer. To address its possibility as a therapeutic target for cancer, we employed RNA interference technique to knockdown AURKA expression analyzed phenotypes. We found specific cultured cancer cells strongly suppressed vitro cell growth vivo tumorigenicity. The induced...
Abstract Background Postoperative pancreatic fistula (POPF) remains one of the most common causes morbidity following pancreaticoduodenectomy (PD). This randomized trial examined whether external stent drainage duct decreases rate POPF after PD and subsequent pancreaticojejunostomy (PJ). Methods Consecutive patients who underwent with construction a duct-to-mucosa PJ were into stented non-stented group. The primary outcome was incidence clinically relevant POPF. Secondary outcomes mortality...
In Brief Objective: To examine the clinicopathologic features and clonal relationship of multifocal intraductal papillary mucinous neoplasms (IPMNs) pancreas. Background: Intraductal are increasingly diagnosed cystic precursor lesions pancreatic cancer. can be a potential cause recurrence after partial pancreatectomy. Methods: Thirty four patients with histologically documented IPMNs were collected their catalogued. addition, thirty arising in 13 from 3 hospitals subjected to laser...
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Along with large-scale loss of life, infrastructural damage, and material losses, health issues have become a crucially important problem after natural disasters. Survivors must confront the threat risks, especially infectious diseases, as result limited supplies, services, facilities. Limited knowledge about risks following disasters, in addition to lack awareness, contributes occurrence diseases that are fundamentally preventable. This study was conducted review eight major disasters...
Dendritic cells (DCs) activated by CD40L-expressing CD4+ T act as mediators of "T helper (Th)" signals for CD8+ lymphocytes, inducing their cytotoxic function and supporting long-term activity. Here, we show that the optimal activation DCs, ability to produce high levels bioactive interleukin (IL)-12p70 induce Th1-type cells, is supported complementary DC-activating from both cells. Cord blood- or peripheral blood-isolated naive do not express CD40L, but, in contrast they are efficient...
Small pancreatic cancers, intractable diseases, offer the possibility of cure. Can this be true? Through National Pancreatic Cancer Registry, Japan Pancreas Society (JPS) has collected 822 cases invasive cancer with tumors <2 cm in diameter (TS1 cancer). Papillary adenocarcinoma and well-differentiated type tubular are more frequent TS1 than larger tumors, suggesting that further genetic phenotypic changes occur during their progression. Patients presented abdominal pain, jaundice,...
Abstract Periostin is a secretory protein that has been suggested to function as cell adhesion molecule and promote the invasiveness or growth rate of tumors. However, little known about association its expression epithelial mesenchymal transition (EMT), which considered play crucial role in cancer metastasis. Thus, authors investigated whether periostin could be involved process EMT this gene pancreatic development. The was observed mainly stromal cells but very by immunohistochemistry...
Invasive ductal adenocarcinoma (IDA) of the pancreas manifests poor prognosis due to early invasion and distant metastasis. In contrast, intraductal papillary mucinous adenoma or carcinoma (IPMA IPMC) reveals better clinical outcomes. Various molecular mechanisms contribute these differences but entire picture is still unclear. Recent researches emphasized important role miRNA in biological processes including cancer We previously described that miR-126 down-regulated IDA compared with IPMA...