Masakazu Yamamoto
A5001076934- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Hepatitis C virus research
- Appendicitis Diagnosis and Management
- Cancer, Lipids, and Metabolism
Tokyo Women's Medical University
2015-2024
Saiseikai Utsunomiya hospital
2021-2024
Tohoku University
2020-2024
Japan Pancreatic Disease Research Foundation
2024
Joint Center for Structural Genomics
2024
Yamagata University
2004-2023
Cambridge University Hospitals NHS Foundation Trust
2023
Yokohama City University
2022
Tokyo Medical and Dental University
2022
Keio University
2022
Intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic cystic that often invasive and metastatic, resulting in poor prognosis. Few molecular alterations unique to IPMN are known. We performed whole-exome sequencing for primary tissue, which uncovered somatic mutations KCNF1, DYNC1H1, PGCP, STAB1, PTPRM, PRPF8, RNASE3, SPHKAP, MLXIPL, VPS13C, PRCC, GNAS, KRAS, RBM10, RNF43, DOCK2 CENPF. further analyzed GNAS archival cases of 118 IPMNs 32 ductal adenocarcinomas (PDAs), revealed...
Abstract Background Although some retrospective studies have suggested the value of adjuvant therapy, no recommended standard exists in bile duct cancer. The aim this study was to test hypothesis that gemcitabine chemotherapy would improve survival probability resected Methods This a randomized phase III trial. Patients with cancer were assigned randomly and observation groups, which balanced respect lymph node status, residual tumour status location. Gemcitabine given intravenously at dose...
Highlights•Biliary tract cancers are clinically and genetically heterogeneous.•32 significantly mutated genes were identified, some negatively affecting prognosis.•A novel deletion of MUC17 at 7q22.1 was detected.•Cell-of-origin predictions suggest hepatocyte-origin hepatitis-related ICCs.•Deleterious germline mutations cancer-predisposing detected in 11% patients with BTC.Graphical abstractAbstractBackground & AimsBiliary (BTCs) pathologically heterogeneous respond poorly to treatment....
<h3>Objective</h3> The clinicopathological significance of four morphological types intraductal papillary mucinous neoplasms the pancreas (IPMNs; gastric, intestinal, pancreatobiliary and oncocytic) was assessed. <h3>Design</h3> Retrospective multicentre analysis 283 surgically resected IPMNs. <h3>Results</h3> Of IPMNs, 139 were gastric type, 101 19 24 oncocytic. These significantly associated with factors including sex (p=0.0032), age (p=0.00924), ectatic duct size (p=0.0245), detection...
Intrahepatic cholangiocarcinoma and combined hepatocellular show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying phenotype (LCB). LCB is second in the incidence for cancers with without chronic hepatitis background more aggressive than carcinoma (HCC). To gain insight into its molecular alterations, we performed whole-genome sequencing analysis on 30 LCBs. Here show, genome-wide substitution patterns LCBs developed livers overlapped...
Objective: The aim of this study was to define robust benchmark values for the surgical treatment perihilar cholangiocarcinomas (PHC) enable unbiased comparisons. Background: Despite ongoing efforts, postoperative mortality and morbidity remains high after complex liver surgery PHC. Benchmark data best achievable results in PHC are however still lacking. Methods: This analyzed consecutive patients undergoing major 24 high-volume centers 3 continents over recent 5-year period (2014–2018) with...
The Brisbane 2000 Terminology for Liver Anatomy and Resections, based on Couinaud's segments, did not address how to identify segmental borders anatomic territories of less than one segment. Smaller resections including segmentectomies subsegmentectomies, have been well defined. advent minimally invasive liver resection has enhanced the possibilities more precise due a magnified view reduced bleeding, (MIALR) is becoming popular gradually. Therefore, there need updating system, segmentectomy...
Laparoscopic liver resection for hepatocellular carcinoma (HCC) in Child-Pugh A cirrhosis has been demonstrated as beneficial. However, the role of laparoscopy B is undetermined. The aim this retrospective cohort study was to compare open and laparoscopic HCC with cirrhosis.Data on resections were gathered from 17 centres. 1 : propensity score matching performed according predefined variables.Of 382 available resections, 100 matched analysed. 90-day postoperative mortality rate similar...
An analysis of molecular phylogeny was undertaken to examine whether the evolution hepadnavirus family is host-dependent. Using nucleotide sequences 18 strains, we constructed phylogenetic trees. The trees obtained show that all 12 strains hepatitis B virus can be classified into four subgroups are not compatible with conventional subtypes. We estimated rate synonymous (silent) substitution for 4.57 x 10(-5) per site year. Applying this tree, duck diverged from a common ancestor about 30,000...
The only curative treatment in biliary tract cancer is surgical treatment. Therefore, the suitability of resection should be investigated first place. In presence metastasis to liver, lung, peritoneum, or distant lymph nodes, not suitable. No definite consensus has been reached on local extension factors and curability. Measures hepatic functional reserve jaundiced liver include future remnant volume indocyanine green (ICG) clearance test. Preoperative portal vein embolization may considered...
It is important to predict the development of clinically relevant pancreatic fistula (grade B/C) in early period after pancreaticoduodenectomy (PD). This study has been carried out as a project Japanese Society Hepato-Biliary-Pancreatic Surgery (JSHPBS) evaluate predictive factors associated with B/C).The data 1,239 patients from 11 medical institutions who had undergone PD between July 2005 and June 2009 were retrospectively analyzed review patient characteristics perioperative...
We have encountered cases of unusual intraductal pancreatic neoplasms with predominant tubulopapillary growth. collected data on 10 similar “intraductal (ITPNs)” and analyzed their clinicopathologic molecular features. Tumor specimens were obtained from 5 men women a mean age 58 years. ITPNs solid nodular tumors obstructing dilated ducts did not contain any visible mucin. The tumor cells formed tubulopapillae contained little cytoplasmic exhibited uniform high-grade atypia. Necrotic foci...