A5106033733- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Gallbladder and Bile Duct Disorders
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Renal cell carcinoma treatment
- Viral-associated cancers and disorders
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Cardiac Ischemia and Reperfusion
Hôpital Paul-Brousse
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris-Saclay
2012-2025
European Society for Organ Transplantation
2021-2025
European Society for Blood and Marrow Transplantation
2025
Université Paris-Sud
2015-2024
Inserm
2014-2023
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2006-2022
Hotel Dieu Hospital
2021
Cereep Ecotron Île-de-France
2021
In Brief Objective: To evaluate the long-term survival of patients resected for primarily unresectable colorectal liver metastases (CRLM) downstaged by systemic chemotherapy and to use prognostic factors outcome a model predictive on preoperative setting. Summary Background Data: Surgery CRLM after downstaging is still questioned, are lacking. Methods: From consecutive series 1439 with managed in single institution during an 11-year period (1988–1999), 1104 (77%) initially (NR) were treated...
Objective Currently, there is considerable controversy about the place of transplantation in treatment hepatocellular carcinoma (HCC). This study compared resection to cirrhotic patients with HCC order determine reasonable indications each treatment. Summary Background Data The usual procedure resect when feasible and transplant other cases. Methods Three-year survival without recurrence was analyzed 60 who underwent transplantation. Several prognostic factors, such as size, number nodules,...
Since 1968 the European Liver Transplant Registry (ELTR) collects prospectively data of liver transplantation (LT) in 145 centers all over Europe. It represents more than 95% overall compared to published official figures [[1]International on organ donation and activities 2009. http://www.transplant-observatory.org.Google Scholar]. This collection is made through a standardized questionnaire. The first part questionnaire includes items regarding date indication for LT, donor recipient data,...
To assess feasibility, risks, and patient outcomes in the treatment of colorectal metastases with two-stage hepatectomy.Some patients multiple hepatic are not candidates for a complete resection by single hepatectomy, even when downstaged chemotherapy, after portal embolization, or combined locally destructive technique. In highest possible number tumors is resected first, noncurative intervention, remaining period liver regeneration. selected irresectable amenable to hepatectomy procedure,...
Although oncosurgical strategies have demonstrated increased survival in patients with unresectable colorectal liver metastases (CLM), their potential for cure is still questioned. The aim of this study was to evaluate long-term outcome after combining downsizing chemotherapy and rescue surgery define prognostic factors cure.All initially CLM who underwent had a minimum follow-up 5 years were included. Cure defined as disease-free interval > or = from last hepatic extrahepatic resection...
Objective To assess the influence of preoperative portal vein embolization (PVE) on long-term outcome liver resection for colorectal metastases. Summary Background Data Preoperative PVE induces hypertrophy remnant and increases safety hepatectomy. Methods Thirty patients underwent 88 did not before four or more segments. was performed when estimated rate functional parenchyma (ERRFLP) assessed by CT scan volumetry less than 40%. Results feasible in all patients. There were no deaths. The...
Abstract An international panel of multidisciplinary experts convened to develop recommendations for the management patients with liver metastases from colorectal cancer (CRC). The aim was address main issues facing CRC hepatobiliary team (MDT) when managing such and standardize treatment receive in different centers. Based on current evidence, group agreed a number including following: (a) primary is achieving long disease-free survival (DFS) interval following resection; (b) assessment...
To determine the risk, benefit, and main factors of prognosis third liver resections for recurrent colorectal metastases.
Journal Article Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients Colorectal Cancer Metastases: a Randomized Multi-institutional Trial Get access Francis A. Lévi, Lévi Search for other works by this author on: Oxford Academic PubMed Google Scholar Rachid Zidani, Zidani Jean-Michel Vannetzel, Vannetzel Bruno Perpoint, Perpoint Christian Focan, Focan Roberto Faggiuolo, Faggiuolo Philippe...
We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC).In a prospective-randomized open-label international trial, 525 LTx recipients HCC initially receiving mammalian target of rapamycin inhibitor-free were randomized 4 to 6 weeks after into group on (group A: 264 patients) or incorporating sirolimus B: 261). The primary endpoint was recurrence-free survival (RFS); intention-to-treat (ITT)...
The authors assess the long-term results of repeat hepatectomies for recurrent metastases colorectal cancer and determine factors that can predict survival.Safer techniques hepatic resection have allowed surgeons to consider hepatectomy in an increasing number patients. However, higher operative bleeding increased morbidity been reported after hepatectomies, benefit these procedures needs be evaluated.Sixty-four patients from a group 243 resected liver were submitted 83 (64 second, 15 third,...
Alcohol-related liver disease (ALD) is one of the most common indications for transplantation (LT). Long-term outcome after LT ALD versus other etiologies still under debate. The aim this study was to compare patients with ALD, viral (VIR), and cryptogenic cirrhosis. Donor, graft recipient ELTR variables were analysed in transplants alcoholic nonalcoholic cirrhosis (1988-2005) correlated patient survival. Causes death and/or failure compared between groups. Nine thousand eight hundred eighty...