Luciano De Carlis
A5039259452- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Hepatitis C virus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- COVID-19 Clinical Research Studies
- Neurological Complications and Syndromes
- Liver Diseases and Immunity
- Congenital Anomalies and Fetal Surgery
- Renal and Vascular Pathologies
- Long-Term Effects of COVID-19
- Pediatric Hepatobiliary Diseases and Treatments
- Viral-associated cancers and disorders
- SARS-CoV-2 and COVID-19 Research
- Liver physiology and pathology
- Cytomegalovirus and herpesvirus research
- Colorectal Cancer Treatments and Studies
- Genetic and Kidney Cyst Diseases
University of Milano-Bicocca
2016-2025
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2016-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2004-2025
Azienda Socio Sanitaria Territoriale Lariana
2018-2024
Ospedale Maggiore
1996-2024
University of Milan
1982-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2024
Società Italiana di Reumatologia
2019-2023
University of Pisa
2016-2022
Science Health Allied Research Education
2022
In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) reduced-exposure (EVR+Reduced TAC) or (iii) standard-exposure Control). Randomization TAC Elimination was terminated prematurely due higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced noninferior Control for the primary efficacy endpoint (tBPAR, graft loss death 12 months...
Objective: The aim of this study was to estimate probabilities achieving the statistical cure from hepatocellular carcinoma (HCC) with hepatic resection (HR) and liver transplantation (LT). Background: Statistical occurs when mortality a specific population returns values that general population. Resection are considered potentially curative therapies for HCC, but their effect on residual entire life-expectancy has never been investigated. Methods: Data 3286 HCC patients treated LT (n =...
Liver graft utilization rates are a hot topic due to the worldwide organ shortage and increasing number of transplant candidates on waiting lists. perfusion techniques have been introduced in several countries, may help increase supply, as they potentially enable assessment livers before use.Liver offers were counted from donation after circulatory death (DCD) donors (Maastricht type III) arising during past decade eight including Belgium, France, Italy, Netherlands, Spain, Switzerland, UK,...
Objective: The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Summary Background Data: Coupled improvements in chemotherapy radiation, contemporary approach to surgery supports resection BR-PDAC and, a lesser extent, LA-PDAC. Guidelines outlining selection for these are lacking. Methods: Scottish Intercollegiate Network (SIGN)...
The aim of this study was to identify predictors both survival and tumor-free a cohort 155 patients, with hepatocellular carcinoma (HCC) cirrhosis, who were treated by orthotopic liver transplantation (OLT).From January 1989 December 2002, 603 OLTs performed in 549 patients. HCC diagnosed 116 patients before OLT 39 at histological examination the explanted livers. Eighty-four percent met "Milan" criteria histology. Ninety-four received anticancer therapies preoperatively.The median follow-up...
In a 24-month prospective, randomized, multicenter, open-label study, de novo liver transplant patients were randomized at 30 days to everolimus (EVR) + Reduced tacrolimus (TAC; n = 245), TAC Control (n 243) or Elimination 231). Randomization was stopped prematurely due significantly higher rate of treated biopsy-proven acute rejection (tBPAR). The incidence the primary efficacy endpoint, composite failure tBPAR, graft loss death postrandomization similar with EVR (10.3%) (12.5%) month 24...
Calcineurin inhibitors (CNIs) contribute to renal dysfunction following liver transplantation. This prospective, randomized, multicenter, 6-month study (with an additional 6 months of follow-up) evaluated whether everolimus with CNI reduction or discontinuation would improve function in maintenance transplant recipients experiencing CNI-related impairment. Patients started therapy (n = 72) continued receiving standard-exposure 73). At month 6, 80% the patients who had converted discontinued...
Data are lacking regarding the long-term effect of preemptive conversion to everolimus from calcineurin inhibitors early after liver transplantation avoid renal deterioration.In a prospective, multicenter, open-label study, de novo transplant patients were randomized at day 30 (i) + reduced exposure tacrolimus (EVR Reduced TAC), (ii) elimination (TAC Elimination), or (iii) standard Control).Randomization TAC Elimination was terminated prematurely due higher rate treated biopsy-proven acute...
The role of donation after cardiac death (DCD) in expanding the donor pool is mainly limited by incidence primary nonfunction (PNF) and ischemia-related complications. Even greater concern exists toward uncontrolled DCD, which represents largest potential DCD donors. We recently started first Italian series liver transplantation, using normothermic regional perfusion (NRP) 6 donors 1 controlled case to deal with legally required no-touch period 20 minutes. examined our 7 cases for PNF, early...
Expansion of donor acceptance criteria for liver transplant increased the risk early allograft failure (EAF), and although EAF prediction is pivotal to optimize outcomes, there no consensus on specific indicators or timing evaluate EAF. Recently, Liver Graft Assessment Following Transplantation (L-GrAFT) algorithm, based aspartate transaminase, bilirubin, platelet, international normalized ratio kinetics, was developed from a single-center database gathered 2002 2015.To develop validate...
In January 2020, Novel Coronavirus Disease 2019 (COVID-19) resulted in a global pandemic, creating uncertainty toward the management of liver transplantation (LT) programs. Lombardy has been most affected region Italy: current mortality rate COVID-19 patients is 18.3% (10 022 deaths; April 10th) with hospitals having to expand total number ICU beds from 724 1381 accommodate infected patients. There drastic decrease donors. From February 23rd until 10th, 17 LTs were performed Lombardy. Mean...
Donation after circulatory death (DCD) in Italy, given its 20-min stand-off period, provides a unique bench test for normothermic regional perfusion (NRP) and dual hypothermic oxygenated machine (D-HOPE).We coordinated multicenter retrospective Italian cohort study with 44 controlled DCD donors, who underwent NRP, to present transplant characteristics results. To rank our results according the high donor risk, we matched compared subgroup of 37 livers, preserved NRP D-HOPE, static-preserved...