A5042471747- Bariatric Surgery and Outcomes
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Body Contouring and Surgery
- Renal Transplantation Outcomes and Treatments
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet and metabolism studies
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Liver physiology and pathology
- Gastroesophageal reflux and treatments
- Transplantation: Methods and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hernia repair and management
- Minimally Invasive Surgical Techniques
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Cell death mechanisms and regulation
- Cardiac Ischemia and Reperfusion
- Pancreatitis Pathology and Treatment
Hôpital l'Archet
2016-2025
Centre Hospitalier Universitaire de Nice
2014-2023
Inserm
2012-2023
Université Côte d'Azur
2014-2023
Institut Pasteur de Lille
2023
Université de Lille
2023
Fédération Francophone de Cancérologie Digestive
2023
Centre Hospitalier Universitaire de Lille
2023
Assistance Publique – Hôpitaux de Paris
2020-2022
Hospital Universitario Austral
2022
We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC).In a prospective-randomized open-label international trial, 525 LTx recipients HCC initially receiving mammalian target of rapamycin inhibitor-free were randomized 4 to 6 weeks after into group on (group A: 264 patients) or incorporating sirolimus B: 261). The primary endpoint was recurrence-free survival (RFS); intention-to-treat (ITT)...
T-cell regulation in adipose tissue provides a link between inflammation and insulin resistance. Because of alterations composition obesity, we aimed to identify the antigen-presenting cells obese mice patients with Dendritic (DCs) T were studied two cohorts patients. In lean mice, only CD11c(+) DCs detected tissue. Adoptive transfer naive CD4(+) Rag1(-/-) led predominant Th1 response contrast, during obesity (human CD11c(+)CD1c(+) mouse CD11c(high)F4/80(low)) accumulated...
Abstract The incidence of chronic liver disease is constantly increasing, owing to the obesity epidemic. However, causes and mechanisms inflammation-mediated damage remain poorly understood. Endoplasmic reticulum (ER) stress an initiator cell death inflammatory mechanisms. Although induces ER stress, interplay between hepatic NLRP3 inflammasome activation hepatocyte signaling has not yet been explored during etiology diseases. Steatosis a common disorder affecting obese patients; moreover,...
Apoptosis is activated during the early phase of reperfusion after liver ischemia and transplantation in animals. However, molecular basis ischemia-induced cell death remains poorly understood. In this study we show that hepatocytes from ischemic lobes undergo apoptosis reperfusion. vivo pretreatment rats with a specific inhibitor caspases abrogates apoptotic response lobes. Inhibition can be accounted for by total inhibition caspase activation as assessed an enzymatic assay affinity...
Background Obesity modulates inflammation and activation of immune pathways which can lead to liver complications. We aimed at identifying expression patterns inflammatory response genes specifically associated with obesity NASH in the morbidly obese patients. Methodology/Principal Findings Expression 222 was evaluated by quantitative RT-PCR patients histologically normal (n = 6), or severe steatosis without 6) lean controls 5). Hepatic 58 out upregulated The most notable changes occurred...
The actual impact of transarterial chemoembolization before liver transplantation (LT) for hepatocellular carcinoma (HCC) on patient survival and HCC recurrence is not known. Between 1985 1998, 479 patients with in 14 French centers were evaluated LT. Among these patients, this case-control study included 100 who received LT (TACE group) control did receive (no-TACE group). Patients controls matched the pre-LT tumor characteristics, period transplantation, time spent waiting list, pre-...
Objective The authors present their experience in the laparoscopic management of benign liver disease. aim study is to analyze technical feasibility and evaluate immediate long-term outcome. Summary Background Data Indications for varied abdominal conditions have evolved. Although minimally invasive treatment cysts has been reported, approach other lesions remains undefined. Methods Between September 1990 October 1997, 43 patients underwent surgery. There were two groups lesions: (n = 31)...
OBJECTIVE C-Reactive Protein (CRP), a nonspecific marker of inflammation that is moderately elevated in obesity, metabolic syndrome (MS), and type 2 diabetes, has been proposed as surrogate nonalcoholic steatohepatitis (NASH). Its clinical usefulness the diagnosis NASH was evaluated severely obese patients without or with MS, potential roles liver adipose tissue CRP production were characterized. METHODS Severely (without MS [N = 13], 11], diabetes 7]) 8] 7] MS) studied. For each patient,...
Orthotopic liver transplantation (OLT) indication for hepatocellular carcinoma (HCC) is currently based on the Milan criteria. The University of California, San Francisco (UCSF) recently proposed an expansion selection criteria according to tumors characteristics explanted liver. This study: 1) assessed validity these in independent large series and 2) tested usefulness when applied pre-OLT tumor evaluation. Between 1985 1998, 479 patients were listed (LT) HCC 467 transplanted. According...
Abstract Background The potential anti-cancer effects of mammalian target rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic in the pure oncology setting, and at present, no endpoint-directed RCT has reported high-malignancy risk population immunosuppressed transplant recipients. Interestingly, since mTOR both immunosuppressive effects, they simultaneously protect against...
Aliment Pharmacol Ther 2010; 32: 1315–1322 Summary Background Non‐invasive approaches are useful to differentiate simple steatosis from non‐alcoholic steatohepatitis (NASH) in obese and morbidly patients. Aim To develop a new scoring system diagnose definitive NASH. Methods Preoperative clinical biological data including serum caspase 3‐generated cytokeratin‐18 fragments (CK18) surgical liver biopsies were obtained 464 patients who had undergone bariatric surgery. The cohort was divided into...
Osteopontin (OPN) plays an important role in the development of insulin resistance and liver complications dietary murine models. We aimed to determine expression pattern OPN its receptor CD44 obese patients mice according steatosis.OPN expressions were studied 52 morbidly mice. Cellular studies performed HepG2 cells.Hepatic strongly correlated with steatosis This increased could be due accumulation triglycerides, since fat loading promotes expression. In contrast, adipose tissue (AT) was...
Between 2003 and 2012, 42 869 first liver transplantations performed in Europe with the use of either University Wisconsin solution (UW; N = 24 562), histidine-tryptophan-ketoglutarate(HTK; 8696), Celsior (CE; 7756) or Institute Georges Lopez preservation (IGL-1; 1855) preserved grafts. Alternative solutions to UW were increasingly used during last decade. Overall, 3-year graft survival was higher UW, IGL-1 CE (75%, 75% 73%, respectively), compared HTK (69%) (p < 0.0001). The same trend...