A5035519119- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Single-cell and spatial transcriptomics
- Neurogenesis and neuroplasticity mechanisms
- Gut microbiota and health
- Computational Drug Discovery Methods
- Chemokine receptors and signaling
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Eating Disorders and Behaviors
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Endoplasmic Reticulum Stress and Disease
- Infant Health and Development
- Congenital heart defects research
Heinrich Heine University Düsseldorf
2016-2024
Deutsches Diabetes-Zentrum e.V.
2016-2024
Helmholtz Zentrum München
2016-2024
German Center for Diabetes Research
2016-2024
Université Côte d'Azur
2013-2023
Observatoire de la Côte d’Azur
2023
Center for Environmental Health
2022
Diabetes Australia
2021
Institut de Pharmacologie Moléculaire et Cellulaire
2012-2021
Centre National de la Recherche Scientifique
2015-2021
Abstract The incidence of chronic liver disease is constantly increasing, owing to the obesity epidemic. However, causes and mechanisms inflammation-mediated damage remain poorly understood. Endoplasmic reticulum (ER) stress an initiator cell death inflammatory mechanisms. Although induces ER stress, interplay between hepatic NLRP3 inflammasome activation hepatocyte signaling has not yet been explored during etiology diseases. Steatosis a common disorder affecting obese patients; moreover,...
Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated β-amyloid precursor protein (βAPP swe ), P310L-Tau (Tau P301L and physiological levels of M146V-presenilin-1 (PS1 M146V ) display extracellular amyloid-β peptides (Aβ) deposits Tau tangles. More disputed is the observation that these accumulate intraneuronal Aβ has been linked to synaptic dysfunction cognitive deficits. Here, we provide immunohistological, genetic, pharmacological evidences for early, age-dependent,...
Pathologies of the micro- and macrovascular systems are a hallmark metabolic syndrome, which can lead to chronically elevated blood pressure. However, underlying pathomechanisms involved still need be clarified. Here, we report that an obesity-associated increase in serum leptin triggers select expansion micro-angioarchitecture pre-autonomic brain centers regulate hemodynamic homeostasis. By using series cell- region-specific loss- gain-of-function models, show this pathophysiological...
Highlights•Global and hypothalamic Cited1 loss exacerbates diet-induced obesity in female mice•Cited1 is highly enriched estradiol-sensitive melanocortin neurons•Hypothalamic molecularly links the effects of E2 leptin on food intake•Cited1 PomcARC neurons acts as a downstream co-factor for E2-leptin signalingSummaryUntil menopause, women have lower propensity to develop metabolic diseases than men, suggestive protective role sex hormones. Although functional synergy between central actions...
In humans, obesity is associated with brain inflammation, glial reactivity, and immune cells infiltration. Studies in rodents have shown that reactivity occurs within 24 hr of high-fat diet (HFD) consumption, long before development, takes place mainly the hypothalamus (HT), a crucial structure for controlling body weight. Here, we sought to characterize postprandial HT inflammatory response 1, 3, 6 exposure either standard (SD) or HFD. HFD increased gene expression astrocyte microglial...
Abstract Hypothalamic astrocytes are particularly affected by energy‐dense food consumption. How the anatomical location of these glial cells and their spatial molecular distribution in arcuate nucleus hypothalamus (ARC) determine cellular response to a high caloric diet remains unclear. In this study, we investigated distinctive responses following exposure high‐fat high‐sugar (HFHS) diet, specifically ARC. Using RNA sequencing proteomics, showed that have distinct transcriptomic proteomic...
Abstract Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark obesity‐associated disorders, thermogenic adipocytes linked to cardiometabolic health. As dynamically adapt environmental cues by functionally switching between phenotypes, molecular understanding this plasticity could help improving metabolism. Here, we show that the lncRNA Apoptosis associated transcript in bladder cancer (AATBC) human‐specific regulator plasticity....
Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, molecular underpinnings by which PVNOT orchestrate gut-to-brain feeding control remain unclear. Here, we show that mice undergoing selective ablation of fail reduce food intake in response CCK and develop hyperphagic obesity on a chow diet. Notably, exposing wild-type high-fat/high-sugar (HFHS)...
Although the short-term effects of fasting or energy deficit on hypothalamic neuropeptide circuitries are now better understood, long-term and refeeding remain to be elucidated. We showed that after a deficit,<b> </b>mice exhibited persistent hypoleptinemia following period despite restoration fat mass, ovarian activity, feeding behavior. aimed examine adaptations 10 weeks further nutritional recovery. To do so, we assessed mRNA levels leptin receptor main orexigenic anorexigenic...
Anorexia nervosa (AN) is a severe eating disorder where caloric restriction, excessive physical activity and metabolic alterations lead to life-threatening situations. Despite weight restoration after treatment, significant part of patients experience relapses. In this translational study, we combined clinical preclinical approaches. We describe preliminary data about the effect gain on symptomatology suffering from acute AN (n = 225) partially recovered 41). measured more precisely with...
Abstract In humans, obesity was associated with brain inflammation and glial cell proliferation. Studies in rodents showed that proliferation occurs within 24 hours of high-fat diet (HFD) consumption, before development. This mainly observed the hypothalamus (HT), a crucial structure for controlling body weight. Therefore, we sought to characterize post-prandial HT inflammatory response 1-3-6 exposure standard HFD. HFD increased gene expression astrocyte microglial marker (GFAP Iba1) compare...
The hypothalamus is a primary brain area which, in mammals, regulates several physiological functions that are all related to maintaining general homeostasis, by linking the central nervous system (CNS) and periphery. itself can be considered an endocrine region of some sort as it hosts its different nuclei kinds neuropeptide-producing -secreting neurons. These neuropeptides have specific roles participate regulation homeostasis general, which includes energy metabolism, feeding behavior,...
Abstract Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark obesity-associated disorders, the activation thermogenic brown beige adipocytes linked to improved cardiometabolic health. As dynamically adapt environmental cues by functionally switching between phenotypes, molecular understanding this plasticity could help improving balance weight loss. Here, we show that long non-coding RNA (lncRNA) Apoptosis associated transcript...