Albert Tran
A5062593266- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Lipid metabolism and disorders
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Diseases and Immunity
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Hepatitis Viruses Studies and Epidemiology
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
Inserm
2016-2025
Centre Hospitalier Universitaire de Nice
2015-2025
Université Côte d'Azur
2016-2025
University of Oklahoma Health Sciences Center
2024-2025
Hôpital l'Archet
2014-2024
Centre Méditerranéen de Médecine Moléculaire
2013-2022
Hôpital Pasteur
2022
Institut de Biologie Valrose
2020-2022
Observatoire de la Côte d’Azur
2017-2021
Fédération française de cardiologie
2008-2017
Background & AimsElafibranor is an agonist of the peroxisome proliferator−activated receptor-α and receptor-δ. Elafibranor improves insulin sensitivity, glucose homeostasis, lipid metabolism reduces inflammation. We assessed safety efficacy elafibranor in international, randomized, double-blind placebo-controlled trial patients with nonalcoholic steatohepatitis (NASH).MethodsPatients NASH without cirrhosis were randomly assigned to groups given 80 mg (n = 93), 120 91), or placebo 92) each...
Alcoholic and nonalcoholic fatty liver disease (ALD NAFLD) are the predominant causes of liver-related mortality in Western countries. We have shown that limiting classical (M1) Kupffer cell (KC) polarization reduces alcohol-induced injury. Herein, we investigated whether favoring alternatively activated M2 KCs may protect against ALD NAFLD. Ongoing alcohol drinkers morbidly obese patients, with minimal hepatic injury steatosis, displayed higher expression genes, as compared to patients more...
T-cell regulation in adipose tissue provides a link between inflammation and insulin resistance. Because of alterations composition obesity, we aimed to identify the antigen-presenting cells obese mice patients with Dendritic (DCs) T were studied two cohorts patients. In lean mice, only CD11c(+) DCs detected tissue. Adoptive transfer naive CD4(+) Rag1(-/-) led predominant Th1 response contrast, during obesity (human CD11c(+)CD1c(+) mouse CD11c(high)F4/80(low)) accumulated...
Abstract The incidence of chronic liver disease is constantly increasing, owing to the obesity epidemic. However, causes and mechanisms inflammation-mediated damage remain poorly understood. Endoplasmic reticulum (ER) stress an initiator cell death inflammatory mechanisms. Although induces ER stress, interplay between hepatic NLRP3 inflammasome activation hepatocyte signaling has not yet been explored during etiology diseases. Steatosis a common disorder affecting obese patients; moreover,...
Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effectors RIPK3-dependent death. Here, we directly test this idea employing method for specific removal via mitophagy. Mitochondria-deficient cells were resistant to pathway apoptosis, but efficiently died tumor factor (TNF)-induced, programmed or...
Nonalcoholic steatohepatitis (NASH) is a condition which can progress to cirrhosis and hepatocellular carcinoma. Markers for NASH diagnosis are still lacking. We performed comprehensive lipidomic analysis on human liver biopsies including normal liver, nonalcoholic fatty NASH. Random forests-based machine learning approach allowed characterizing signature of 32 lipids discriminating with 100% sensitivity specificity. Furthermore, we validated this in an independent group patients. Then,...
Fatigue is a frustrating symptom frequently reported by patients with primary biliary cirrhosis (PBC), but it still poorly understood and not well evaluated. Our aim was to determine its importance impact on the quality of life mental health status PBC.Patients PBC (103 women 13 men mean age 52.6 yr) completed self-report questionnaires evaluate fatigue their (Fatigue Impact Scale, FIS), perception own (Symptom Check list-90-R, SCL), depression (Beck Depression Inventory, BDI). A cohort...
After describing two cases of Hashimoto's thyroiditis associated with chronic hepatitis C, we set up a prospective study to assess the prevalence thyroid autoantibodies (thyroglobulin and microsomal autoantibodies) in 72 C patients (43 men 29 women; mean age = 51 +/- 2.1 yr) before interferon therapy admitted between January December 1991 our liver unit. Thyroid were systematically assayed 60 HBsAg-positive (34 26 50 2.2 yr), who served as controls. Antibody virus was detected...
Background Obesity modulates inflammation and activation of immune pathways which can lead to liver complications. We aimed at identifying expression patterns inflammatory response genes specifically associated with obesity NASH in the morbidly obese patients. Methodology/Principal Findings Expression 222 was evaluated by quantitative RT-PCR patients histologically normal (n = 6), or severe steatosis without 6) lean controls 5). Hepatic 58 out upregulated The most notable changes occurred...
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite growing number studies linking with altered serum metabolite levels, an obstacle development metabolome-based NAFLD predictors has been lack large cohort data biopsy-proven patients matched for key metabolic features such as obesity. We studied 467 biopsied individuals normal histology (n = 90) or diagnosed (steatosis,...
A subset of patients with irritable bowel syndrome (IBS) have an increased number mast cells (MCs) in the colonic mucosa. Psychological factors are believed to contribute course IBS.To examine associations between fatigue, depression and MCs mucosa IBS.Colonic biopsies were taken from 50 Rome II IBS patients, 21 healthy controls 11 depressed/fatigued without IBS. The cellularity lamina propria was determined as inflammatory per high power field (hpf) through a 400x microscope. Fatigue Impact...
Abstract Data concerning the fine structure of 12q13‐15 amplicon which contains MDM2 and CDK4 in well‐differentiated dedifferentiated liposarcomas (WDLPS/DDLPS) are scarce. We investigated a series 38 WDLPS/DDLPS using fluorescence situ hybridization analysis with 17 probes encompassing region. In addition, quantitative RT‐PCR we studied expression , DDIT3 (CHOP/GADD153), DYRK2 HMGA2, TSPAN31 YEATS4 (GAS41 ) 11 cases. showed that (12q14.1) belonged to distinct than (12q15). There was no...
OBJECTIVE C-Reactive Protein (CRP), a nonspecific marker of inflammation that is moderately elevated in obesity, metabolic syndrome (MS), and type 2 diabetes, has been proposed as surrogate nonalcoholic steatohepatitis (NASH). Its clinical usefulness the diagnosis NASH was evaluated severely obese patients without or with MS, potential roles liver adipose tissue CRP production were characterized. METHODS Severely (without MS [N = 13], 11], diabetes 7]) 8] 7] MS) studied. For each patient,...
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic in western countries. Current NAFLD diagnosis methods (e.g., biopsy analysis or imaging techniques) are poorly suited as tests for such a prevalent condition, from both clinical and financial point view. The present work aims to demonstrate potential utility serum metabolic profiling defining phenotypic biomarkers that could be useful management. A parallel animal model/human exploratory metabolomics approach was...
Fibrotest (FT) and Actitest (AT) are biochemical markers of fibrosis activity for use as a non-invasive alternative to liver biopsy in patients with chronic hepatitis C virus (HCV). The aim this study was perform an external validation FT AT the discordances between FT/AT C.A total 519 consecutive HCV were prospectively included five centers, taken at same day. Fifteen excluded because their biopsies could not be interpreted. Diagnostic accuracies assessed by receiver operating...