A5006812658- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Endoplasmic Reticulum Stress and Disease
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Pancreatitis Pathology and Treatment
- Pregnancy and preeclampsia studies
- Lipid metabolism and disorders
- Hepatitis Viruses Studies and Epidemiology
- Glycosylation and Glycoproteins Research
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Apelin-related biomedical research
- Pulmonary Hypertension Research and Treatments
- Fibroblast Growth Factor Research
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
Ghent University Hospital
2016-2025
Ghent University
2010-2024
ERN RARE-LIVER
2023
Universitair Ziekenhuis Brussel
2007-2021
ERN GUARD-Heart
2021
KU Leuven
2011-2018
John Wiley & Sons (United Kingdom)
2018
Hudson Institute
2018
Euroquality
2018
Creative Research Enterprises (United States)
2016
Background & AimsElafibranor is an agonist of the peroxisome proliferator−activated receptor-α and receptor-δ. Elafibranor improves insulin sensitivity, glucose homeostasis, lipid metabolism reduces inflammation. We assessed safety efficacy elafibranor in international, randomized, double-blind placebo-controlled trial patients with nonalcoholic steatohepatitis (NASH).MethodsPatients NASH without cirrhosis were randomly assigned to groups given 80 mg (n = 93), 120 91), or placebo 92) each...
Background Transarterial chemoembolization (TACE) is the recommended treatment for intermediate hepatocellular carcinoma (HCC) according to Barcelona Clinic Liver Cancer guidelines. Prospective uncontrolled studies suggest that yttrium 90 (90Y) transarterial radioembolization (TARE) a safe and effective alternative. Purpose To compare efficacy safety of TARE with TACE unresectable HCC. Materials Methods In this single-center prospective randomized controlled trial (TRACE), 90Y glass was...
Angiogenesis contributes to the development of nonalcoholic steatohepatitis (NASH) and promotes inflammation, fibrosis, progression hepatocellular carcinoma (HCC). Angiopoietin‐2 (Ang‐2) is a key regulator angiogenesis. We aimed investigate role Ang‐2 its potential as therapeutic target in NASH using human samples, vivo mouse models, vitro assays. Serum levels were determined 104 obese patients undergoing bariatric surgery concomitant liver biopsy. The effect Ang‐2/Tie2 receptor inhibiting...
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other may be more informative. We an atlas of messenger, circular, and small RNA transcriptomes a comprehensive collection 20 human biofluids. By means synthetic spike-in controls, we compare content across biofluids, revealing 10,000-fold difference concentration. The circular fraction is increased compared to tissues. Each biofluid transcriptome...
(1) Background: With new potential drug targets emerging, combination therapies appear attractive to treat non-alcoholic steatohepatitis (NASH) and fibrosis. Chemokine receptor CCR2/5 antagonists can improve fibrosis by reducing monocyte infiltration altering hepatic macrophage subsets. Fibroblast growth factor 21 (FGF21) may NASH modulating lipid glucose metabolism. We compared effects of single treatment as therapeutic strategies against NASH. (2) Methods: analyzed serum samples liver...
Background and Aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. PSC strongly associated with colitis a disruption of the gut-liver axis, macrophages involved in pathogenesis PSC. However, how interactions specific macrophage populations contribute to incompletely understood. Approach Results: We investigated impact cholestasis on hepatic colonic microenvironment, performed...
Keratin 7 positive (K7+) cells are considered to be activated in case of impaired hepatocyte replication. Their exact role and their interaction with hepatocytes macrophages also implicated liver regeneration remain poorly characterized humans. The aim this study is evaluate hepatocyte, K7+ macrophage populations severe alcohol-related steatohepatitis (sASH) link them injury patients' outcomes. Immunohistochemical morphometric studies for total cells, (CD68+ cells), proliferative (Ki67+...
Portopulmonary hypertension (POPH), a complication of chronic liver disease, may be contraindication to transplantation (LT) because the elevated risk peritransplant and posttransplant morbidity mortality. Because POPH is frequently asymptomatic, screening with echocardiography recommended. The only reliable technique, however, for diagnosing right heart catheterization (RHC). aims this study were evaluate current estimated systolic pulmonary artery pressure (sPAP) cutoff value 30 mm Hg...
The pathophysiology of nonalcoholic steatohepatitis (NASH) should be approached as a multifactorial process. In several stages NASH, link between disease progression and hepatic microvasculature changes can made. this study we investigated the role angiogenesis in two mouse models for effect preventive therapeutic antiangiogenic treatment diet-induced model NASH. Protein RNA levels angiogenic inflammatory factors were significantly up-regulated liver C56BL/6 db/db mice with NASH at different...
Abstract Placental growth factor (PlGF) is associated selectively with pathological angiogenesis, and PlGF blockade does not affect the healthy vasculature. Anti-PlGF therefore currently being clinically evaluated for treatment of cancer patients. In cirrhosis, hepatic fibrogenesis accompanied by extensive angiogenesis. this paper, we pathophysiological role therapeutic potential anti-PlGF in liver cirrhosis. was significantly up-regulated CCl4-induced rodent model cirrhosis as well...
Abstract Hepatic encephalopathy (HE) is a common complication of chronic liver disease, characterized by an altered mental state and hyperammonemia. Insight into the brain pathophysiology HE limited due to paucity well-characterized models beyond rat bile duct ligation (BDL) model. Here, we assess presence characteristics in mouse BDL We show that C57Bl/6j mice induces motor dysfunction, progressive fibrosis, function failure hyperammonemia, all hallmarks HE. Swiss however fail replicate...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent pediatric disease, yet accurate risk scores for referral of children/adolescents with suspected clinically significant fibrosis are currently lacking.
Summary The characterization of mice models portal hypertension (PHT) is lacking in the literature. Therefore, aim present study was to make a histological approach during development PHT two cirrhosis with compared one model isolated PHT. developed by partial vein ligation (PPVL). Two hypertensive cirrhotic were either common bile duct (CBDL) or administration carbon tetrachloride (CCl 4 ) subcutaneously (twice weekly, 1 ml/kg). These represent, respectively, secondary biliary and alcoholic...
Abstract Background Functional disturbances of the endoplasmic reticulum (ER) lead to activation unfolded protein response (UPR), which is involved in consecutive steps carcinogenesis. In human hepatocellular carcinoma (HCC), UPR shown be activated; however, little known about kinetics and effects modulation HCC. Methods We sequentially monitored over time an orthotopic mouse model for HCC explored on cell viability proliferation vitro model. Results The expression ER-resident chaperones...