A5030639316- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Cancer, Hypoxia, and Metabolism
- Migraine and Headache Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Nanoparticle-Based Drug Delivery
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Traumatic Brain Injury Research
- Intraperitoneal and Appendiceal Malignancies
- Endoplasmic Reticulum Stress and Disease
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Hepatocellular Carcinoma Treatment and Prognosis
- Lanthanide and Transition Metal Complexes
Ghent University
2016-2025
Ghent University Hospital
2010-2023
Cancer Research Institute Ghent
2023
iMinds
2013-2019
Infinity (United States)
2016-2019
Signal Processing (United States)
2019
Institut Gustave Roussy
2019
VIB-VUB Center for Structural Biology
2016
Vrije Universiteit Brussel
2016
Leiden University Medical Center
2016
Event Abstract Back to Changes in functional brain networks during epileptogenesis a rodent model of temporal lobe epilepsy Emma Christiaen1*, Marie-Gabrielle Goossens2, Benedicte Descamps1, Paul Boon2, Robrecht Raedt2 and Christian Vanhove1 1 Ghent University - IMEC, Department Electronics Information Systems, Belgium 2 University, Neurology, Introduction Temporal (TLE) is the most common form adults. Research has shown that abnormal are involved development generation spread seizures....
Abstract Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAFs are abundantly present, effects RT to CAF and its impact on cancer cells unknown. We evaluated damage responses investigated changes colorectal cell growth, transcriptome, metabolome, kinome response paracrine signals emerging from irradiated CAF. induced DNA damage, p53 activation, cell-cycle...
A generic site‐specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein‐ligation capacity enzyme Sortase to label camelid single‐domain antibody‐fragments, also known as nanobodies. The versatility approach was demonstrated by conjugating independently three different probes: chelating agents CHX‐A"‐DTPA NOTA single‐photon emission computed tomography (SPECT) with indium‐111...
Positron emission tomography-computed tomography (PET-CT) is a highly sensitive clinical molecular imaging modality to study atherosclerotic plaque biology. Therefore, we sought develop new PET tracer, targeting vascular cell adhesion molecule (VCAM)-1 and validate it in murine model as potential agent detect inflammation.The anti-VCAM-1 nanobody (Nb) (cAbVCAM-1-5) was radiolabelled with Fluorine-18 ((18)F), radiochemical purity of >98%. In vitro cell-binding studies showed specific binding...
Differences in brain energy metabolism have been found between migraine patients and controls previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing with aura (MwA). The aim this study was to verify potential changes resting-state without (MwoA) compared control subjects by (31)P-MRS at 3 tesla.Quantification performed using the phantom replacement technique. MRS measurements were interictally medial occipital lobe 19 MwoA 26 age-matched controls.A...
Abstract Background Functional disturbances of the endoplasmic reticulum (ER) lead to activation unfolded protein response (UPR), which is involved in consecutive steps carcinogenesis. In human hepatocellular carcinoma (HCC), UPR shown be activated; however, little known about kinetics and effects modulation HCC. Methods We sequentially monitored over time an orthotopic mouse model for HCC explored on cell viability proliferation vitro model. Results The expression ER-resident chaperones...
// Félix Gremonprez 1 , Benedicte Descamps 2 Andrei Izmer 3 Christian Vanhove Frank Vanhaecke Olivier De Wever 4 Wim Ceelen Department of Surgery, Ghent University Hospital, Ghent, Belgium Infinity (iMinds-IBiTech-MEDISIP), Electronics and Information Systems, University, Atomic Mass Spectrometry, Analytical Chemistry, Radiation Oncology Experimental Cancer Research, Correspondence to: Gremonprez, e-mail: Felix.gremonprez@ugent.be Keywords: peritoneal carcinomatosis, colorectal cancer,...
Although intraperitoneal chemotherapy (IPC) has evolved into an established treatment modality for patients with peritoneal metastasis (PM), drug penetration tumor nodules remains limited. Drug transport during IPC is a complex process that depends on large number of different parameters (e.g. drug, dose, size, pressure, vascularization). Mathematical modeling allows better understanding the processes underlie and relative importance influencing it. In this work, we expanded our previously...
Radiotherapeutic treatment consists of targeted application radiation beams to a tumor but exposure surrounding healthy tissue is inevitable. In the brain, ionizing induces breakdown blood-brain barrier by effects on brain microvascular endothelial cells. Damage from directly irradiated cells can be transferred non-exposed bystander cells, known as radiation-induced effect. We investigated involvement connexin channels and paracrine signaling in DNA damage exposed focused X-rays. Irradiation...
Intra-abdominal dissemination of peritoneal nodules, a condition known as carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced stages. The current treatment PC consists perioperative systemic chemotherapy and cytoreductive surgery, followed by intra-abdominal flushing with solutions chemotherapeutics such cisplatin oxaliplatin. In this study, we developed cisplatin-loaded polyarginine-hyaluronic acid nanoscale particles (Cis-pARG-HA NPs) high colloidal...
// Lynn Feys 1 , Benedicte Descamps 2 Christian Vanhove Anne Vral 3 Liv Veldeman 4 Stefan Vermeulen 5 Carlos De Wagter Marc Bracke and Olivier Wever Department of Radiation Oncology Experimental Cancer Research, Laboratory Ghent University, Ghent, Belgium Electronics Information System, iMinds-IBiTech-MEDISIP, Basic Medical Sciences, Physiology Group, Gent University Hospital, Biomedical Science, HoGent, Correspondence to: Wever, email: Keywords : radiotherapy, triple-negative breast cancer,...
// Yves-Paul Vandewynckel 1 , Debby Laukens Lindsey Devisscher Annelies Paridaens Eliene Bogaerts Xavier Verhelst Anja Van den Bussche Sarah Raevens Christophe Steenkiste Marleen Troys 2 Ampe Benedicte Descamps 3 Chris Vanhove 3, 4 Olivier Govaere 5 Geerts Hans Vlierberghe Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium Biochemistry, Infinity Imaging Lab, GROUP-ID Consortium, Translational Cell Tissue Research, Pathology, University Leuven, Correspondence to:...
Artemisinins are antimalarial drugs that exert potent anticancer activity. We evaluated the effects of artesunate, a semisynthetic derivative artemisinin, on tumor growth, angiogenesis, unfolded protein response, and chemoresistance in hepatocellular carcinoma.The effect artesunate was examined HepG2 BWTG3 cells under normoxic hypoxic conditions diethylnitrosamine-induced mouse model. Histology performed with hematoxylin/eosin reticulin staining. The expression chemoresistance-related...
Prolyl hydroxylase domain-containing proteins (PHDs) regulate the adaptation of cells to hypoxia. Pan-hydroxylase inhibition is protective in experimental colitis, which PHD1 plays a prominent role. However, it currently unknown how targeting regulates this protection and cell type(s) are involved. Here, we demonstrated that Phd1 deletion endothelial haematopoietic (Phd1f/f Tie2:cre) protected mice from dextran sulphate sodium (DSS)-induced with reduced epithelial erosions, immune...
Patients with advanced ovarian cancer develop recurrence despite initial treatment response to standard of surgery and intravenous/intraperitoneal (IP) chemotherapy, partly due a limited peritoneal exposure time chemotherapeutics. Paclitaxel-loaded genipin-crosslinked gelatin microspheres (PTX-GP-MS) are evaluated for the microscopic carcinomatosis prevention recurrent disease. The highest drug load (39.2 µg PTX/mg MS) was obtained by immersion GP-MS in aqueous PTX nanosuspension...
Diffusion magnetic resonance imaging biomarkers can provide quantifiable information of the brain tissue after a mild traumatic injury (mTBI). However, commonly applied diffusion tensor (DTI) model is not very specific to changes in underlying cellular structures. To overcome these limitations, other models have recently emerged more complete view on damage profile following TBI. In this study, we investigated longitudinal advanced metrics experimental mTBI, utilising three different rat...
Epilepsy is a neurological disorder characterized by recurrent epileptic seizures. Electrophysiological and neuroimaging studies in patients with epilepsy suggest that abnormal functional brain networks play role the development of epilepsy, i.e. epileptogenesis, resulting generation spontaneous seizures cognitive impairment. In this longitudinal study, we investigated changes during epileptogenesis intraperitoneal kainic acid (IPKA) rat model temporal lobe (TLE) using resting state magnetic...