A5031058903- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Diabetes Management and Education
- Advanced MRI Techniques and Applications
- Sex and Gender in Healthcare
- Obesity and Health Practices
- Chronic Disease Management Strategies
- Cancer, Lipids, and Metabolism
- Birth, Development, and Health
- Diabetes and associated disorders
- Diabetes Management and Research
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Health Promotion and Cardiovascular Prevention
- Ovarian function and disorders
- Bone health and osteoporosis research
- Pharmacology and Obesity Treatment
- RNA modifications and cancer
Medical University of Vienna
2016-2025
Gender Studies
2016-2017
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2017
Klinik für Frauenheilkunde
2017
National Research Council
2017
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2008
Azienda Ospedaliera Ospedale Maggiore
2008
Azienda Ospedaliero Universitaria Maggiore della Carita
2008
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other may be more informative. We an atlas of messenger, circular, and small RNA transcriptomes a comprehensive collection 20 human biofluids. By means synthetic spike-in controls, we compare content across biofluids, revealing 10,000-fold difference concentration. The circular fraction is increased compared to tissues. Each biofluid transcriptome...
Abstract Obesity, a highly prevalent disorder and central diagnosis of the metabolic syndrome, is linked to mental health by clinical observations biological pathways. Patients with obesity may show long-lasting increases in risk for receiving psychiatric co-diagnoses. Austrian national registry data inpatient services from 1997 2014 were analyzed detect associations between hospital (ICD-10: E66) disorders grouped level-3 ICD-10 codes. Data stratified age decades each pair diagnoses...
Abstract We aim to comprehensively identify typical life-spanning trajectories and critical events that impact patients’ hospital utilization mortality. use a unique dataset containing 44 million records of almost all inpatient stays from 2003 2014 in Austria investigate disease trajectories. develop new, multilayer network approach quantitatively analyze how cooccurrences two or more diagnoses form evolve over the life course patients. Nodes represent age groups ten years; each group makes...
Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in pathogenesis osteoporosis, is not entirely known so far. Consequently, this study was set out to investigate relationship different kinds and dosages statins with hypothesising that inhibition synthesis cholesterol could influence sex-hormones therefore diagnosis osteoporosis. Methods Medical claims data all Austrians from 2006 2007 used identify patients treated compute their daily defined dose...
Introduction Both diabetes mellitus and being female significantly increase the risk of diagnosed with major depressive disorder (MDD). The diagnosis MDD, combined mellitus, can be detrimental in terms mortality morbidity. We aimed at investigating impact on gender gap MDD over course a human lifetime. Research design methods In cross-sectional study 17 years, medical claims data general Austrian population (n=8 996 916) between 1997 2014 was analyzed. Of these, 123 232 patients were...
Abstract Aims To investigate the potential synergistic effects of combined exenatide (EXE) and dapagliflozin (DAPA) versus (PLAC) placebo DAPA on hepatocellular lipid (HCL) reduction after 24 weeks treatment. Materials methods Thirty patients with type 2 diabetes were randomized to weekly EXE daily (n = 16) or PLAC 14). Inclusion criteria glycated haemoglobin (HbA1c) 48 97 mmol/mol (6.5‐11%), age 18 75 years, body mass index (BMI) ≥25 kg/m metformin ≥1000 mg. The primary endpoint, HCL...
Summary Recent human and animal studies have found associations between gut microbiota composition serum levels of sex hormones, indicating that they could be an important factor in shaping the microbiota. However, little is known about effect regular hormonal fluctuations over menstrual cycle or CHC‐related changes hormone on structure, diversity dynamics. The aim this study was to investigate CHCs composition. CHC pill intake studied a group seven healthy pre‐menopausal women using pill,...
Abstract Acetylcarnitine is an essential metabolite for maintaining metabolic flexibility and glucose homeostasis. The in vivo behavior of muscle acetylcarnitine content during exercise has not been shown with magnetic resonance spectroscopy. Therefore, this study aimed to explore the skeletal rest, plantar flexion exercise, recovery human gastrocnemius under aerobic conditions. Ten lean volunteers nine overweight participated study. A 7 T whole-body MR system a double-tuned surface coil was...
Zusammenfassung Metabolische Erkrankungen beeinflussen das Leben von Männern und Frauen in den verschiedenen Lebensabschnitten unterschiedlicher vielfältiger Weise stellen eine große Herausforderung für Gesundheitssystem dar. Die behandelnden Ärztinnen Ärzte sind mit unterschiedlichen Bedürfnissen im klinischen Alltag konfrontiert. Geschlechtsspezifische Unterschiede die Pathophysiologie, Screening Diagnose Krankheiten, sowie Behandlungsstrategien Entwicklung Komplikationen Mortalitätsraten....
Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations following RYGB.Sixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese control and normal weight women) were included. Frequently sampled 3 h OGTTs 1 IVGTTs performed between 24 28 weeks gestation and, a subgroup, repeated at 3-6 months...
Blood glucose is lower in mountain dwellers living under low partial oxygen pressure. We show that obese mice maintained hypoxia exhibit a delayed but distinct decrease blood with improved insulin sensitivity, which independent of changes body weight. This effect mediated by erythropoiesis and direct result the rising hematocrit, could be due to erythrocytes acting as carriers units blood. Glucose lowering red cell mass evidenced prompt glycemia receiving transfusion. Furthermore, life well...
Abstract Aim Metabolic disorders are established risk factors for coronary artery disease (CAD) and major adverse cardiovascular events (MACE). Although obesity is closely associated with metabolic disease, data on its role as a separate modifier in metabolically healthy individuals limited, particularly patients CAD. Thus, this study aims to investigate profiles of phenotypes outcomes undergoing invasive angiography (ICA). Methods 12,760 evaluated chronic syndrome (CCS) were distinguished...
OBJECTIVE In our randomized controlled trial, we investigated the impact of healthy eating (HE) aiming for restricted gestational weight gain (GWG) and physical activity (PA) interventions on maternal neonatal lipid metabolism. RESEARCH DESIGN AND METHODS Obese pregnant women (n = 436) were included before 20 weeks’ gestation underwent glucose testing (oral tolerance test) profiling at baseline 24–28 35–37 weeks after an least 10-h overnight fast. This secondary analysis had a factorial...
Posttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] impaired fasting [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of plasma (FPG) HbA
Combining mouse experiments with big data analysis of the Austrian population, we investigated association between high-dose statin treatment and bone quality.The microarchitecture femur vertebral body L4 was measured in male ovariectomized female mice on a high-fat diet containing simvastatin (1.2 g/kg). A sex-specific matched health insurance claims using multiple logistic regression models conducted (simvastatin 60-80 mg/day vs. controls; males: n = 138,666; females: 155,055).High-dose...
Abstract Objective Standardised person‐reported outcomes (PRO) data can contextualise clinical enabling precision diabetes monitoring and care. Comprehensive outcome sets guide this process, but their implementation in routine care has remained challenging unsuccessful at international level. We aimed to address by developing a person‐centred set for Type 1 2 diabetes, using methodology with prospects increased implementability sustainability health settings. Methods used three‐round...
There are emerging data indicating an association between PCOS (polycystic ovary syndrome) and metabolic derangements with potential impact on its clinical presentation. This study aims to evaluate the pathophysiological processes beyond particular focus carbohydrate metabolism, ectopic lipids their possible interaction. Differences two established classifications of disease should be additionally evaluated.A characterization was performed in 53 untreated patients as well 20 controls...
Objectives: Diabetic patients are often diagnosed with several comorbidities. The aim of the present study was to investigate relationship between different combinations risk factors and complications in diabetic patients. Research design methods: We used a longitudinal, population-wide dataset hospital diagnoses identified all (n = 195,575) receiving diagnosis diabetes observation period from 2003–2014. defined nine ICD-10-codes as 16 ICD-10 codes complications. Using computational...
Abstract Objectives This study aimed to assess the guideline recommended diagnostic tools NT-proBNP and NYHA classification, with a focus on sex-specific differences. Background Patients Type 2 Diabetes (T2D) face heart failure (HF) risk up four times higher than those without T2D, particularly affecting women more twice as much men. Despite distinct pathophysiological differences between men women, there are currently no recommendations for algorithm of HF in diabetic patients. Methods A...
•Statin co-medication was initially associated with a worse DFS in hormone receptor-positive early-stage BC patients.•This effect mainly driven by patients on hydrophilic statins.•However, this subsided after correction for confounders the sensitivity analysis.•No association between statin use and fracture risk or osteoporosis observed. BackgroundStatins are cholesterol-lowering drugs prescribed prevention treatment of cardiovascular disease. Moreover, statins may possess anticancer...