A5068277619- Pancreatic function and diabetes
- Ion channel regulation and function
- Analog and Mixed-Signal Circuit Design
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neural Engineering
Medical University of Vienna
2025
Reutlingen University
2014-2019
Natural and Medical Sciences Institute
2014-2015
University of Tübingen
2011-2015
Blood glucose is lower in mountain dwellers living under low partial oxygen pressure. We show that obese mice maintained hypoxia exhibit a delayed but distinct decrease blood with improved insulin sensitivity, which independent of changes body weight. This effect mediated by erythropoiesis and direct result the rising hematocrit, could be due to erythrocytes acting as carriers units blood. Glucose lowering red cell mass evidenced prompt glycemia receiving transfusion. Furthermore, life well...
Extracellular recording of the glucose-induced electrical activity mouse islets Langerhans on microelectrode arrays (MEAs) is an innovative and powerful tool to address beta-cell (patho-)physiology. In a dual approach we tested whether this technique can detect concentration-dependent drug effects as well characterize alterations in during prolonged culture. First established conditions that allow long-term investigation function by activity. The results provide first measurements membrane...
Increase of blood glucose concentration leads to glucose-induced electrical activity pancreatic beta-cells followed by insulin secretion. Electrical appears in concentration-dependent oscillations easily recorded microelectrode arrays (MEA). In comparison other electrophysiological techniques MEAs can record non-invasively from intact islets and be used for long term studies investigate chronic effects drugs. Murine or isolated human biopsies were recordings. was quantified as fraction...