A5077159130- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Issues in Pregnancy
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Maternal and fetal healthcare
- Congenital Heart Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Cleft Lip and Palate Research
- Enhanced Recovery After Surgery
- Pregnancy-related medical research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Pelvic floor disorders treatments
- Pancreatic function and diabetes
- Calpain Protease Function and Regulation
- Peroxisome Proliferator-Activated Receptors
- Parvovirus B19 Infection Studies
- Cervical Cancer and HPV Research
- Mast cells and histamine
Medical University of Vienna
2015-2024
University of Vienna
2001-2023
Klinik für Frauenheilkunde
2017
Klinikum Klagenfurt
2013-2014
Vienna General Hospital
2000-2012
Universitäts Frauenklinik
2011
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2003-2009
National Bank of Austria
2005
St Anna Children's Hospital
2001
Universidad de Alcalá
2001
To determine whether mode of delivery is associated with the endocrine stress response in mother and child.Prospective observational study.Tertiary care centre, University hospital.A total 103 nulliparous women uncomplicated singleton pregnancies at term undergoing either spontaneous labour for vaginal or delivering by caesarean section without labour. Thirty delivered vaginally any pain relief, 21 epidural anaesthesia, 23 had ventouse extraction 29 underwent analgesia.After delivery,...
Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude diagnostic criteria and screening strategies both high-risk general population. Our aims were report important risk factors GDM development calculate cohort with BMI ≥29 kg/m
Objective: The aim of the study was to evaluate influence mode delivery on female sexuality 12–18 months after childbirth. Methods: Fifty-five primiparae who delivered vaginally without complication and 44 underwent elective cesarean section 37 weeks gestation were included. Sexual function assessed by a validated self-reported questionnaire, Female Function Index (FSFI), 12 birth compared between groups. Additionally, we have analyzed subjective stress variables recorded two Results: Women...
The World Health Organization (WHO) declared certain fungal pathogens as global health threats for the next decade. Candida auris (C. auris) is a newly emerging skin-tropic multidrug-resistant pathogen that can cause life-threatening infections of high mortality in hospitals and healthcare settings. Here, we address an unmet need present novel native ex vivo skin models, thus extending previous C. auris-host interaction studies. We exploit histology immunofluorescence analysis biopsies human...
Abstract Objective Ultrasound is the modality of choice for prenatal detection cleft lip and palate. Because its accuracy in detecting facial clefts, especially isolated clefts secondary palate, can be limited, magnetic resonance imaging (MRI) used as an additional method assessing fetus. The aim this study was to investigate role fetal MRI diagnosis clefts. Methods Thirty‐four pregnant women with a mean gestational age 26 (range, 19–34) weeks underwent utero MRI, after ultrasound...
Background: Mast cells (MC) are multifunctional effector of the immune system. They derive from uncommitted CD34 + hemopoietic progenitor (HPC). Depending on stage maturation and environment, MC variably express differentiation‐ activation‐linked antigens. Little is known, however, about regulation expression such antigens in immature human MC. Methods: We analyzed CD grown cord blood‐derived HPC. The HPC were isolated by magnetic cell sorting (MACS) FACS to >97% purity, cultured stem...
To evaluate whether gestational diabetes mellitus (GDM) requiring insulin treatment (White's classification A2) is associated with an alteration of pregnancy-associated plasma protein-A (PAPP-A) serum levels at first-trimester screening between 11 and 14 weeks gestation.We collected data (2007-2010) all women who developed GDM completed combined program including the determination PAPP-A free β-human chorionic gonadotropin (β-hCG). A total 288 were included in this study. Each 72 was matched...
This study aims to evaluate the prevalence of congenital heart disease (CHD) in monochorionic (MC) twin pregnancies with and without twin-to-twin transfusion syndrome (TTTS) an unselected cohort, which underwent prenatal postnatal echocardiography.This was a retrospective cohort including 451 MC between 2002 2012. Complete outcome data were available for 381 pregnancies. All patients had echocardiography, echocardiography performed all newborns symptoms or follow-up on findings. Data from...
To investigate the effect of postoperative gum chewing on bowel motility after laparoscopic gynecologic surgery.In this randomized controlled trial, patients were allocated to either every 2 hours for 15 minutes or standard care without chewing. The study's primary end points time first regular sounds and passage flatus surgery. Secondary operation defecation, patient satisfaction concerning chewing, potential side effects pain therapy.One hundred seventy-nine included in trial. We found a...
Fetal/neonatal thyrotoxicosis is a rare but potentially life-threatening condition. It most commonly observed in poorly controlled Graves disease during pregnancy. Here we describe fetus/newborn patient with who was born of woman Hashimoto thyroiditis and levothyroxine-treated hypothyroidism. Transplacental passage stimulating thyrotropin (TSH) receptor antibodies, which were measured by cell-based bioassay, the underlying mechanism fetal/neonatal thyrotoxicosis, although mother had no...
Abstract Background In view of the reported increase in obstetric anal sphincter injuries, objective this study was to evaluate incidence such injuries over time and associated risk protective factors. Methods This a retrospective cohort from national database 168 137 primiparous women with term, singleton, cephalic, vaginal delivery between 2008 2014. The main outcome measure injury. A multivariate regression model used identify Results Age >19 years, birthweight >4000 g, operative...
OBJECTIVE In our randomized controlled trial, we investigated the impact of healthy eating (HE) aiming for restricted gestational weight gain (GWG) and physical activity (PA) interventions on maternal neonatal lipid metabolism. RESEARCH DESIGN AND METHODS Obese pregnant women (n = 436) were included before 20 weeks’ gestation underwent glucose testing (oral tolerance test) profiling at baseline 24–28 35–37 weeks after an least 10-h overnight fast. This secondary analysis had a factorial...
Vitamin D deficiency is a common finding in overweight/obese pregnant women and associated with increased risk for adverse pregnancy outcome. Both maternal vitamin obesity contribute to metabolic derangements pregnancy. We aimed assess the effects of D3 supplementation versus placebo on fetal lipids. Main inclusion criteria were: <20 weeks’ gestation, BMI ≥ 29 kg/m2. Eligible (n = 154) were randomized receive (1600 IU/day) or placebo. Assessments performed <20, 24−28 35−37 weeks at birth....
Abstract Objective Serum C‐reactive protein (CRP) concentrations were measured longitudinally throughout pregnancy to test the hypothesis that CRP could relate more closely glucose tolerance than adiposity. Methods The in pregnant women with normal (NGT) and those gestational diabetes mellitus (GDM) at same time as oral (OGTT), 24 th 28 weeks of gestation between 37 38 gestation. Results At end third trimester, GDM had significantly higher levels NGT [median (interquartile range), 9·7 mg L...
Background: Statins are inhibitors of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase, a key enzyme in mevalonic acid (MVA)‐dependent signaling. Recent data suggest that statins exhibit profound inhibitory effects on growth and function various immune cells. In the present study, we examined vitro five different primary human mast cells (MCs), MC progenitors, line HMC‐1. Methods: Histamine release experiments were conducted isolated MCs using an anti‐immunoglobulin E (IgE) antibody....
To evaluate the effect of gestational diabetes on omentin-1 in maternal and cord plasma. As a potent mediator insulin resistance, Omentin-1, an adipokine derived from human adipose placental tissue, may be important player pathophysiology diabetes. This was prospective case–control study. The study included 96 women with pregnant without. Omentin-1 measured at time oral glucose tolerance test, 32 weeks plasma right after delivery umbilical blood by ELISA assay. Over period 2 years, 200...
T cells in human skin play an important role the immune defense against pathogens and tumors. are present already fetal skin, where little is known about their cellular phenotype biological function. Using single-cell analyses, we identified a naive cell population expressing αβ γδ receptors (TCRs) that was enriched intestine but not detected other organs peripheral blood. TCR sequencing data revealed double-positive (DP) αβγδ displayed overlap of CDR3 sequences with single-positive cells....
Congenital heart disease is associated with an increased risk of smaller brain volumes and structural damage, impaired growth supratentorial structures in utero has been linked to poor neurodevelopmental outcomes. However, little known on brainstem cerebellar fetuses congenital disease. Moreover, it not clear whether infratentorial growth, if present, only certain types fetal cardiac defects or altered biometry already present before the third trimester.This study aimed investigate compare...