Guy Brusselle
A5005167055- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Delphi Technique in Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Pulmonary Hypertension Research and Treatments
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Pharmaceutical studies and practices
- Cancer-related molecular mechanisms research
- Systemic Sclerosis and Related Diseases
- Air Quality and Health Impacts
- Nutrition and Health in Aging
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
Ghent University Hospital
2016-2025
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2025
Ghent University
2013-2023
ERN GUARD-Heart
2023
Boston University
2022
Universitair Ziekenhuis Brussel
2012-2022
Delaware Division of Libraries
2022
Regeneron (United States)
2018-2022
University of Coimbra
2022
Some patients with severe asthma have frequent exacerbations associated persistent eosinophilic inflammation despite continuous treatment high-dose inhaled glucocorticoids or without oral glucocorticoids.
Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. Its effectiveness in reducing oral glucocorticoid use patients with severe asthma while maintaining control unknown.We randomly assigned 210 glucocorticoid-treated to receive add-on dupilumab (at dose of 300 mg) or placebo every 2 weeks for 24 weeks. After dose-adjustment period before randomization, doses were adjusted downward trend from week 4 20 then...
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent airway diseases that have a high personal social impact. They likely represent continuum of different may share biological mechanisms ( i.e. endotypes), present similar clinical, functional, imaging and/or features can be observed phenotypes) which require individualised treatment. Precision medicine is defined as “treatments targeted to the needs individual patients on basis genetic, biomarker, phenotypic, or...
<h3>Background</h3> Patients with severe asthma are at increased risk of exacerbations and lower respiratory tract infections (LRTI). Severe is heterogeneous, encompassing eosinophilic non-eosinophilic (mainly neutrophilic) phenotypes. neutropilic airway diseases may benefit from macrolides. <h3>Methods</h3> We performed a randomised double-blind placebo-controlled trial in subjects exacerbation-prone asthma. Subjects received low-dose azithromycin (n=55) or placebo (n=54) as add-on...
Summary To investigate the role of IL‐4 in vivo allergic asthma, we developed a murine model allergen‐induced airway inflammation. Repealed daily exposures actively immunised C57BL/6 mice to aerosolized ovalbumin (OVA) induced peribronchial inflammation and an increase eosinophils lymphocytes bronchoalveolar‐lavage(BAL) fluid. In deficient ( IL4 −/− ) mice, treated same way, there were substantially fewer BAL much less compared with wild type mice. this model, mast cell W/W v similar degree...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Netherlands. targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being expanded by persons 40 over. findings have been presented 1500 research articles reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives...
The Rotterdam Study is an ongoing prospective cohort study that started in 1990 the city of Rotterdam, Netherlands. aims to unravel etiology, preclinical course, natural history and potential targets for intervention chronic diseases mid-life late-life. focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Netherlands. targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. findings have been presented 1200 research articles reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives rationale its design. It also presents summary...
<b>GINA no longer recommends treating adults/adolescents with asthma short-acting bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily corticosteroid-containing inhaler, to reduce risk of severe exacerbations.</b>http://bit.ly/310LLzE
A short, easy-to-use health status questionnaire is needed in the multidimensional assessment of chronic obstructive pulmonary disease (COPD) routine practice. The performance eight-item COPD test (CAT) was analysed 1,817 patients from primary care seven European countries. CAT has a scoring range 0–40 (high score representing poor status). Mean scores indicated significant impairment that related to severity airway obstruction, but within each Global Initiative for Obstructive Lung Disease...
COPD is the third leading cause of death in world and its global burden predicted to increase further. Even though prevalence well studied, only few studies examined incidence a prospective standardized manner. In population-based cohort study (Rotterdam Study) enrolling subjects aged ≥45, was diagnosed based on pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). absence an interpretable within Rotterdam Study, cases were defined as having by physician basis clinical presentation...