Peter J. Castaldi
A5058359938- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- RNA modifications and cancer
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Associations and Epidemiology
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Delphi Technique in Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
- Genomics and Rare Diseases
- RNA and protein synthesis mechanisms
- Respiratory viral infections research
- Pleural and Pulmonary Diseases
- Genetics, Bioinformatics, and Biomedical Research
- Lung Cancer Treatments and Mutations
- Gene expression and cancer classification
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
Vision Technology (United States)
2025
Mass General Brigham
2025
Harvard Pilgrim Health Care
2023
KTH Royal Institute of Technology
2023
Harvard University Press
2009-2022
University of Vermont
2021
The University of Texas Health Science Center at Houston
2020
Baylor College of Medicine
2017-2020
Tracking longitudinal measurements of growth and decline in lung function patients with persistent childhood asthma may reveal links between subsequent chronic airflow obstruction.
Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.
Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified substantial number individuals without COPD who suffer from respiratory symptoms and/or increased There is clear need for an expanded definition that linked to physiologic, structural (computed tomography [CT]) clinical disease. Using data the Genetic Epidemiology study (COPDGene
Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences in computed tomography imaging. These may be driven genetic factors. We hypothesized that a genome-wide association study (GWAS) quantitative imaging would identify loci not previously identified analyses or spirometry. In addition, we sought to determine whether described significant and spirometric were associated emphysema airway...
Rationale: Emphysema occurs in distinct pathologic patterns, but little is known about the epidemiologic associations of these patterns. Standard quantitative measures emphysema from computed tomography (CT) do not distinguish between patterns parenchymal destruction.Objectives: To study with lung-related physiology, function, and health care use smokers.Methods: Using a local histogram-based assessment lung density, we quantified low attenuation 9,313 smokers COPDGene Study. determine if...
Previous studies of chronic obstructive pulmonary disease (COPD) have suggested that genetic factors play an important role in the development disease. However, single-nucleotide polymorphisms are associated with COPD genome-wide association been shown to account for only a small percentage variance phenotypes COPD, such as spirometry and imaging variables. These highly predictive disease, family spirometric heritable.To assess heritability coheritability four major COPD-related...
A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, mechanisms by which contributes to COPD susceptibility are unknown.To determine biologic function of human and murine models discover molecular mechanism influences susceptibility.Fam13a null mice (Fam13a(-/-)) were generated exposed cigarette smoke. The lung inflammatory response airspace size assessed Fam13a(-/-) Fam13a(+/+)...
Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there fewer studies that have investigated multiple and replicated in large well-characterized cohorts of susceptible current former smokers. We two MSD multiplex panels measure 9 cytokines chemokines 2123 subjects from COPDGene 1117 SPIROMICS. These included: interleukin (IL)-2, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, eotaxin/CCL-11,...
Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD) renders identifying different trajectories challenging.Objectives: To identify subtypes patients with COPD distinct longitudinal patterns using a novel machine-learning tool called "Subtype and Stage Inference" (SuStaIn) to evaluate the utility SuStaIn for patient stratification in COPD.Methods: We applied cross-sectional computed tomography imaging markers 3,698 Global Initiative Chronic Obstructive Lung...
The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics preeminent method for detection, but isoform-resolved proteomic analysis relies on accurate reference databases that match sample; neither a subset nor superset database ideal. Long-read RNA sequencing (e.g., PacBio or Oxford Nanopore) provides full-length transcripts which can be used predict isoforms.
Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease (COPD), immune cell landscape lung tissue patients with mild-moderate has not been well characterized at single-cell and molecular level. Objectives: To define from COPD resolution. Methods: We performed transcriptomic, proteomic, T-cell receptor repertoire analyses on (n = 5, Global Initiative for Chronic Obstructive Lung Disease I or II), emphysema without airflow obstruction 5), end-stage 2),...
Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.
Identification of COPD disease-causing genes is an important tool for understanding why develops, who at highest risk, and how new treatments can be developed. Previous genetic studies have identified a highly significant association near nephronectin (NPNT), gene involved in tissue repair, but the biological mechanisms underlying this are unknown. Splicing quantitative trait locus analysis (sQTL) was performed to identify common variants that alter RNA splicing lung tissues. These sQTL...
Long-read RNA-seq has shed light on transcriptomic complexity, but questions remain about the functionality of downstream protein products. We introduce Biosurfer, a computational approach for comparing isoforms, while systematically tracking transcriptional, splicing, and translational variations that underlie differences in sequences Using we analyzed 35,082 pairs GENCODE annotated finding majority (70%) variable N-termini are due to alternative transcription start sites, only 9% arise...
Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung on chest computed tomography. Current guidelines recommend COPD diagnostic schemas that do not incorporate imaging abnormalities. To determine whether a multidimensional schema includes tomographic abnormalities identifies additional individuals with disease. This cohort study included 2 longitudinal cohorts: the Genetic...
Emphysema is a heritable trait that occurs in smokers with and without chronic obstructive pulmonary disease. distinct pathologic patterns, but the genetic determinants of these patterns are unknown.To identify loci associated emphysema investigate regulatory function loci.Quantitative measures were generated from computed tomography scans COPDGene Study using local histogram quantification method. Genome-wide association studies (GWAS) performed 9,614 subjects for five results referenced...