A5037733639- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Pleural and Pulmonary Diseases
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Congenital Diaphragmatic Hernia Studies
- Extracellular vesicles in disease
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Neurogenetic and Muscular Disorders Research
- Pneumonia and Respiratory Infections
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Climate Change and Health Impacts
- Sarcoidosis and Beryllium Toxicity Research
- Amyotrophic Lateral Sclerosis Research
- Immune Cell Function and Interaction
Baylor College of Medicine
2022-2025
University of Arizona
2013-2024
Brigham and Women's Hospital
2012-2023
Lovelace Respiratory Research Institute
2014-2023
Baylor University
2023
Pulmonary Associates
2017-2023
Dermatology Research Center
2020-2022
Pulmonary and Critical Care Associates
2018-2021
Harvard University
2012-2019
Manchester University NHS Foundation Trust
2018
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has dramatically changed our world, country, communities, and families. There is controversy regarding risk factors for severe COVID-19 disease. It been suggested that asthma allergy are not highly represented as comorbid conditions associated with COVID-19.Our aim was to extend work in IL-13 biology determine whether airway epithelial cell expression of key mediators critical SARS-CoV-2 infection, namely, angiotensin-converting...
Coughing is an important defensive reflex that occurs through the stimulation of a complex arc. It accounts for significant number consultations both at level general practitioner and respiratory specialists. In this review we first analyze cough under normal conditions; then anatomy neuro-pathophysiology The aim to provide anatomic pathophysiologic elements evaluation multiple etiologies cough.
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in pathogenesis chronic obstructive pulmonary disease (COPD) unclear. We measured CC16 expression humans with and without COPD function a cigarette smoke (CS)-induced murine model. Airway was patients, smokers non-smokers. exposed wildtype (WT) CC16(-/-)mice to CS or air for up 6 months, expression, inflammation, alveolar septal apoptosis, airspace enlargement, mucin 5AC (MUC5AC) small...
Chronic obstructive pulmonary disease (COPD) is characterized by chronic expiratory airflow obstruction that not fully reversible. COPD patients develop varying degrees of emphysema, small and large airway disease, various co‐morbidities. It has been clear whether these co‐morbidities share common underlying pathogenic processes with the lesions. Early research into pathogenesis focused on contributions injury to extracellular matrix epithelial cells. More recently, cigarette smoke‐induced...
Patients with chronic obstructive pulmonary disease (COPD) have increased lymphoid follicle (LF) counts. B cell-activating factor of tumor necrosis family (BAFF) regulates cells in health, but its role COPD pathogenesis is unclear.To determine whether BAFF expression LFs correlates severity, LF size or number, and/or readouts B-cell function LFs.We correlated immunostaining lung explants biopsies from nonsmoking control subjects (NSC), smokers without (SC), and patients the number LFs,...
A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, mechanisms by which contributes to COPD susceptibility are unknown.To determine biologic function of human and murine models discover molecular mechanism influences susceptibility.Fam13a null mice (Fam13a(-/-)) were generated exposed cigarette smoke. The lung inflammatory response airspace size assessed Fam13a(-/-) Fam13a(+/+)...
Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of characteristically affecting elderly occur at earlier age in subjects diagnosis COPD.
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading to accelerated lung aging, apoptosis, emphysema, as well systemic pathologies. Metformin is beneficial for protecting against aging-related diseases. Objectives: We sought investigate whether metformin may ameliorate CS-induced pathologies of emphysematous chronic obstructive pulmonary disease (COPD). Methods: Mice were exposed chronically CS fed metformin-enriched chow the second half exposure....
Globally, nearly 400 million persons have COPD, and COPD is one of the leading causes hospitalisation mortality across world. While it has been long-recognised that an inflammatory lung disease, dissimilar to asthma, type 2 inflammation was thought play a minor role. However, recent studies suggest in approximately third patients with may be important driver disease potential therapeutic target. Importantly, immune cells molecules involved COPD-related immunity significantly different from...
Rationale: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated hypoxemia.Objectives: To determine whether (1) cigarette smoke (CS)-induced and injury explains the association between COPD, (2) CS-induced is linked to increases in oxidative stress–advanced glycation end products (AGEs) receptor for AGEs (RAGE) pathway, (3) enalapril (which has antioxidant properties) limits progression by reducing...
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) document has modified the grading system directing pharmacotherapy, but how this relates to previous one from 2015 and comorbidities, hospitalizations, mortality risk is unknown.The aim of study was evaluate changes in GOLD groups 2017 assess impact on severity, within each group.We prospectively enrolled followed, a mean 5 years, 819 patients with chronic obstructive pulmonary disease (84% male) clinics Spain United States....
The availability of chest computed tomography (CT) imaging can help diagnose comorbidities associated with chronic obstructive pulmonary disease (COPD). Their systematic identification and relationship all-cause mortality have not been explored. Furthermore, whether their CT-detected prevalence differs from clinical diagnosis is unknown.The 10 CT-assessed was retrospectively determined at baseline in 379 patients (71% men) mild to severe COPD attending clinics. Anthropometrics, smoking...
Background The lifetime risk of developing clinical COPD among smokers ranges from 13% to 22%. Identifying at-risk individuals who will develop overt disease in a reasonable timeframe may allow for early intervention. We hypothesised that readily available and physiological variables could help identify ever-smokers at higher chronic airflow limitation (CAL). Methods Among 2273 Lovelace Smokers’ Cohort (LSC) participants, we included 677 (mean age 54 years) with normal spirometry baseline...
Chronic obstructive pulmonary disease (COPD) is a disorder characterized by an abnormal inflammatory response that persists even after smoking cessation, yet the underlying mechanisms are not fully understood.To investigate expression of B-cell activating factor tumor necrosis family (BAFF), crucial mediator in crosstalk between innate and adaptive immune responses, patients with COPD to explore its correlation severity.Using immunohistochemistry, BAFF was examined lung specimens from 21...
Abstract A disintegrin and a metalloproteinase domain (ADAM) 9 is known to be expressed by monocytes macrophages. In this study, we report that ADAM9 also product of human murine polymorphonuclear neutrophils (PMNs). not synthesized de novo circulating PMNs. Rather, protein stored in the gelatinase specific granules secretory vesicles Unstimulated PMNs express minimal quantities surface ADAM9, but activation with degranulating agonists rapidly (within 15 min) increases PMN levels. Human...