A5039268187- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric health and respiratory diseases
- Extracellular vesicles in disease
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Air Quality and Health Impacts
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Respiratory viral infections research
- Protease and Inhibitor Mechanisms
- Eosinophilic Esophagitis
- Transplantation: Methods and Outcomes
- Respiratory and Cough-Related Research
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Epigenetics and DNA Methylation
- Blood properties and coagulation
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
University of Padua
2016-2025
University of Ferrara
2012
University of Milan
2011
University of Modena and Reggio Emilia
2003-2006
Airway remodeling and inflammation are characteristic features of adult asthma that still poorly investigated in childhood asthma.To examine epithelial vascular changes as well the inflammatory response airways children with asthma.We analyzed bronchial biopsies obtained from 44 undergoing bronchoscopy for appropriate clinical indications other than asthma: 17 mild/moderate (aged 2-15 yr), 12 atopy without (1-11 15 control or (1-14 yr). By histochemistry immunohistochemistry, we quantified...
Inflammation, oxidative stress and apoptosis, which are involved in chronic obstructive pulmonary disease (COPD) pathogenesis, may activate the p38 subgroup of mitogen-activated protein kinases (MAPKs). Therefore, aim present study was to evaluate expression phosphorylated, active form MAPK (phospho-p38) lungs COPD patients. Surgical specimens were obtained from 18 smokers with at different stages severity, plus nine smoking eight nonsmoking subjects normal lung function. Phospho-p38+ cells...
Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies childhood asthma. To evaluate the airway children with we analyzed obtained from 23 undergoing bronchoscopy for clinical indications other than Nine had mild/moderate Six atopy without and eight no or We measured basement membrane thickness quantified number of eosinophils, mast cells, neutrophils, macrophages, T lymphocytes, positive cells transforming growth...
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung, yet mechanisms that regulate this immune-inflammatory response are not fully understood.We investigated whether IL-32, newly discovered cytokine, was related to markers inflammation and clinical progression in COPD.Using immunohistochemistry, expression IL-32 examined surgically resected specimens from 40 smokers with COPD (FEV(1) = 39 +/- 4% predicted), 11 normal lung function, 9 nonsmoking control...
Rationale: Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears resolve by adolescence nonatopic children.Objectives: To investigate whether among children with multitrigger wheeze responsive bronchodilators the airway pathology would be different wheezers, who are often considered nonasthmatic, compared frequently diagnosed as having asthma.Methods: Bronchial biopsies were obtained from...
It is known that tissue macrophages derive not only from blood monocytes but also yolk sac or fetal liver, and the of residence guides their function. When isolated, they lose specific signatures, hence studies human should be ideally done directly in tissue. The aim this study was to investigate lung polarization alveolar macrophage (AM), classic (M1) alternative (M2), health disease, using COPD as a model. Surgical lungs 53 subjects were studied: 36 smokers whose FEV1 varied normal severe...
The clinical course in idiopathic pulmonary fibrosis (IPF) is highly heterogeneous, with some patients having a slow progression and others an accelerated functional decline. This study aims to clinically characterize the type of IPF investigate pathological basis that might account for observed differences disease behavior. Clinical data were analyzed 73 patients, followed long-time as candidates lung transplantation. forced vital capacity (FVC) change/year (< or ≥10% predicted) was used...
Cancer is characterized by chronic inflammation and hypercoagulability, with an excess of venous thromboembolism (VTE). Tissue factor, the initiator blood coagulation, circulates associated extracellular vesicles (EV-TF). Studies investigating EV-TF between cancer-associated non-cancer-associated VTE are lacking. We therefore compared in unprovoked (U-VTE), (C-VTE), cancer without (C-w/o VTE). also investigated interleukin-6 (IL-6) levels same groups. The final population included 68...
Is the methylation status of methylenetetrahydrofolate reductase (MTHFR) promoter region in semen samples associated with 'recurrent spontaneous abortion' (RSA)? MTHFR hypermethylation is more frequent from RSA couples than infertile no history (NRSA) and affects whole sperm population significantly often. Modifications to gene such as polymorphisms methylations are male infertility. Retrospective cohort study 20 couples, 147 NRSA fertile men between 2011 2012. DNA RSA, were analyzed by...
Chronic obstructive pulmonary disease (COPD) is a disorder characterized by an abnormal inflammatory response that persists even after smoking cessation, yet the underlying mechanisms are not fully understood.To investigate expression of B-cell activating factor tumor necrosis family (BAFF), crucial mediator in crosstalk between innate and adaptive immune responses, patients with COPD to explore its correlation severity.Using immunohistochemistry, BAFF was examined lung specimens from 21...
Noneosinophilic asthma is increasingly recognised as an important clinical-pathological phenotype in adults. However, this entity has scarcely been investigated children. In particular, it unknown whether airway remodelling would develop children with non-eosinophilic to the same degree eosinophilic disease. We analysed bronchial biopsies from 80 undergoing bronchoscopy for appropriate clinical indications: 21 noneosinophilic asthma, 34 and 25 control Features of - basement membrane...
Rationale: COPD is a complex disease with heterogeneous manifestations. Attempts have been made to define different phenotypes that could guide toward better understanding. We described before smokers can develop either panlobular (PLE) or centrilobular emphysema (CLE). The latter has worse small airways remodeling and narrowing, which account for the airflow obstruction similar asthma.Objectives: Because of involvement in CLE asthma, we hypothesized role mast cells but not PLE. Hence,...
α1-Antitrypsin (AAT) is a potent protease inhibitor, deficiency of which associated with the presence emphysema. An imbalance elastase and antielastase, along innate inflammation in lung, believed to cause lung destruction α1-antitrypsin (AATD). It now apparent that AAT has important immune-regulatory roles would be lost AATD, yet adaptive immune responses have not been investigated patients AATD.To assess response severe AATD emphysema compare it present "usual" chronic obstructive...
Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How predict if early wheeze will become asthma still matter vivid debate. In this work, we sought assess the clinical and pathological factors that might future development children. Eighty (mean age 3.8 ± 1 yr) who underwent clinically indicated bronchoscopy were followed prospectively for median 5 years. At baseline, characteristics with...
Background Recent literature has shown the presence of B cells and autoantibodies in idiopathic pulmonary fibrosis (IPF) which would imply tertiary lymphoid structures (TLS, sites where immune response is triggered), yet TLS are not considered features histological characteristics IPF. Aim This study aims to quantify presence, size, degree activation biopsied explanted lungs from patients with early- late-IPF, never treated antifibrotics, relate their activity clinical course, disease...
Microvesicles (MVs) released from almost all cells are recognized as cell communication tools. MVs have been investigated in several inflammatory diseases but poorly biological fluids like bronchoalveolar lavage (BAL) of smokers. The purpose this study was to investigate the presence and source BAL smokers with without chronic obstructive pulmonary disease (COPD) compared nonsmoking controls. Using flow cytometry BAL, we detected endothelial alveolar macrophage (AM)-derived found a higher...