A5024567040- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Respiratory and Cough-Related Research
- Medical Imaging and Pathology Studies
- Dysphagia Assessment and Management
- Airway Management and Intubation Techniques
- IL-33, ST2, and ILC Pathways
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Genetic and Kidney Cyst Diseases
- Eosinophilic Esophagitis
- Foreign Body Medical Cases
- Cardiac Arrest and Resuscitation
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Genomics and Rare Diseases
- Hepatitis C virus research
- Inhalation and Respiratory Drug Delivery
- Healthcare Technology and Patient Monitoring
Cell and Gene Therapy Catapult
2024
University of Oxford
2024
University of Padua
2013-2023
Canadian Respiratory Research Network
2016
University of Bern
2012
Institute of Social and Preventive Medicine
2012
The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the remains difficult despite array sophisticated diagnostic There no "gold standard" reference test. Hence, a Task Force supported by European Respiratory Society has developed this guideline to provide evidence-based recommendations on testing, especially in light new developments such tests, need for robust diagnoses patients who might enter randomised...
Primary ciliary dyskinesia (PCD) is associated with abnormal structure and function, which results in retention of mucus bacteria the respiratory tract, leading to chronic oto-sino-pulmonary disease, situs abnormalities sperm motility. The diagnosis PCD requires presence characteristic clinical phenotype either specific ultrastructural defects identified by transmission electron microscopy or evidence function. Although management children affected remains uncertain limited, it important...
Primary ciliary dyskinesia (PCD) is a hereditary disorder of mucociliary clearance causing chronic upper and lower airways disease. We determined the number patients with diagnosed PCD across Europe, described age at diagnosis risk factors for late diagnosis. Centres treating children in Europe answered questionnaires provided anonymous patient lists. In total, 223 centres from 26 countries reported 1,009 aged < 20 yrs. Reported cases per million (for 5-14 yr olds) were highest Cyprus (111),...
Tracheomalacia and tracheobronchomalacia may be primary abnormalities of the large airways or associated with a wide variety congenital acquired conditions. The evidence on diagnosis, classification management is scant. There no universally accepted severity. Clinical presentation includes early-onset stridor fixed wheeze, recurrent infections, brassy cough even near-death attacks, depending site severity lesion. Diagnosis usually made by flexible bronchoscopy in free-breathing child but...
There is increasing awareness of bronchiectasis in children and adolescents, a chronic pulmonary disorder associated with poor quality life for the child/adolescent their parents, recurrent exacerbations, costs to family health systems. Optimal treatment improves clinical outcomes. Several national guidelines exist, but there are no international guidelines. The European Respiratory Society (ERS) Task Force management paediatric sought identify evidence-based (investigation treatment)...
Rationale: Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears resolve by adolescence nonatopic children.Objectives: To investigate whether among children with multitrigger wheeze responsive bronchodilators the airway pathology would be different wheezers, who are often considered nonasthmatic, compared frequently diagnosed as having asthma.Methods: Bronchial biopsies were obtained from...
The European Respiratory Society Task Force on primary ciliary dyskinesia (PCD) in children recently published recommendations for diagnosis and management. This paper compares these with current clinical practice Europe. Questionnaires were returned by 194 paediatric respiratory centres caring PCD patients 26 countries. In most countries, care was not centralised, a median (interquartile range) of 4 (2-9) treated per centre. Overall, 90% had access to nasal or bronchial mucosal biopsy....
Background Children’s interstitial lung diseases (chILD) cover many rare entities, frequently not diagnosed or studied in detail. There is a great need for specialised advice and internationally agreed subclassification of entities collected register. Our objective was to implement an international management platform with independent multidisciplinary review cases at presentation long-term follow-up test if this would allow more accurate diagnosis. Also, quality reproducibility diagnostic...
The global burden of children and young people (CYP) with bronchiectasis is being recognised increasingly. They experience a poor quality life recurrent respiratory exacerbations requiring additional treatment, including hospitalisation. However, there are no published data on patient-driven clinical needs and/or research priorities for paediatric bronchiectasis. Parent/patient-driven views required to understand the inform changes that benefit CYP reduce their disease burden. European Lung...
Noneosinophilic asthma is increasingly recognised as an important clinical-pathological phenotype in adults. However, this entity has scarcely been investigated children. In particular, it unknown whether airway remodelling would develop children with non-eosinophilic to the same degree eosinophilic disease. We analysed bronchial biopsies from 80 undergoing bronchoscopy for appropriate clinical indications: 21 noneosinophilic asthma, 34 and 25 control Features of - basement membrane...
Pulmonary exacerbations are a cause of significant morbidity in patients with primary ciliary dyskinesia (PCD) and frequently used as an outcome measure clinical research into chronic lung diseases. So far, there has been no consensus on the definition pulmonary PCD. 30 multidisciplinary experts developed for children adults Following systematic review, panel modified Delphi process combination face-to-face meetings e-surveys to develop that can be settings A exacerbation was defined by...
Background. Aims of this study were to investigate whether hepatitis C virus infection influences the incidence and natural history intrahepatic cholestasis pregnancy (ICP) ICP has different characteristics in (HCV) positive women from HCV negative women. Methods. A prospective for prevalence was carried out 5840 patients admitted Prenatal Department Padua University, Italy, between January 1996 1999. Testing done by enzyme linked immunosorbent assay (ELISA 3), recombinant immuno blot (RIBA...
Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How predict if early wheeze will become asthma still matter vivid debate. In this work, we sought assess the clinical and pathological factors that might future development children. Eighty (mean age 3.8 ± 1 yr) who underwent clinically indicated bronchoscopy were followed prospectively for median 5 years. At baseline, characteristics with...
In primary ciliary dyskinesia (PCD) impaired mucociliary clearance leads to recurrent airway infections and progressive lung destruction, concern over chronic infection patient-to-patient transmission is considerable. So far, there has been no defined consensus on how control across centres caring for patients with PCD. Within the BEAT-PCD network, COST Action ERS CRC together ERN-Lung PCD core a first initiative now taken towards creating such statement.A multidisciplinary international...
Background Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome. Methods A retrospective, descriptive multicentre follow-up study initiated from the European network for translational research in children's adult interstitial lung disease (Cost Action CA16125) chILD-EU CRC (the Research Collaboration Children's Interstitial Lung Disease). Inclusion criteria were DAH of any cause diagnosed before...
Abstract Aim Eighteen years have passed since the last European survey concerning practices in pediatric bronchoscopy was conducted. Therefore, members of Respiratory Society (ERS) Pediatric Bronchology Group 7.7, initiated “European Bronchoscopy Survey 2015,” which aimed to assess current state this evolving diagnostic and therapeutic procedure field respiratory medicine. Method A questionnaire sent national representatives 44 countries with request distribute it all centers performing...