A5078209693- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Hematopoietic Stem Cell Transplantation
- Pleural and Pulmonary Diseases
- Delphi Technique in Research
- Voice and Speech Disorders
- Transplantation: Methods and Outcomes
- Vascular Anomalies and Treatments
- Childhood Cancer Survivors' Quality of Life
- Neuroscience of respiration and sleep
- Medical Imaging and Pathology Studies
- Complement system in diseases
- Pulmonary Hypertension Research and Treatments
- Advanced Mathematical Modeling in Engineering
Copenhagen University Hospital
2016-2025
Rigshospitalet
2016-2025
Keele University
2019
University of Copenhagen
2009-2018
Gentofte Hospital
2005-2013
Copenhagen Prospective Studies on Asthma in Childhood
2005-2013
Statens Serum Institut
2013
Aarhus University Hospital
2013
Hvidovre Hospital
2000
Pathological features of the airway in young children with severe recurrent wheeze suggest an association between bacterial colonization and initiating events early asthma. We conducted a study to investigate possible hypopharynx asymptomatic neonates later development wheeze, asthma, allergy during first 5 years life.The subjects were from Copenhagen Prospective Study on Asthma Childhood birth cohort who born mothers Aspirates hypopharyngeal region 1-month-old infants cultured for...
We hypothesized that asthma is preceded by a stage of recurrent episodes wheezing during the first years life and inhaled corticosteroid therapy symptomatic in this early phase may delay progression to persistent wheezing.We assigned one-month-old infants treatment with two-week courses budesonide (400 mug per day) or placebo, initiated after three-day episode wheezing, single-center, randomized, double-blind, prospective study three years' duration. The primary outcome was number...
A high infection burden in early childhood is common and a risk factor for later disease development. However, longitudinal birth cohort studies investigating early-life of antibiotic episodes are lacking.
<h3>Objectives</h3> To describe the development of atopic dermatitis (AD) during first 3 years life and identify localization early skin lesions that predicts AD. <h3>Design</h3> Prospective, longitudinal, birth cohort study children born to mothers with a history asthma, followed up for scheduled visits every 6 months as well onset or acute exacerbations symptoms. <h3>Setting</h3> The was recruited from greater Copenhagen, Denmark, at clinical research unit, which controlled all diagnoses...
<h3>Background</h3> The lung clearance index (LCI) derived from the multiple breath inert gas washout (MBW) test reflects global ventilation distribution inhomogeneity. It is more sensitive than forced expiratory volume in 1 s (FEV<sub>1</sub>) for detecting abnormal airway function and correlates closely with structural damage children cystic fibrosis, which shares features primary ciliary dyskinesia (PCD). Normalised phase III slope indices S<sub>cond</sub> S<sub>acin</sub> reflect of...
Background Although aerobic fitness is regarded as an overall prognostic measure of morbidity and mortality, its evaluation in the chronic progressive sinopulmonary disease primary ciliary dyskinesia (PCD) has been infrequently inconsistently reported. Here we assessed peak oxygen uptake (VO2peak) a large well-characterized cohort PCD patients, explored whether VO2peak was associated with parameters pulmonary function, self-reported physical limitations, activity level. Methods VO2peak,...
Clinical management of primary ciliary dyskinesia (PCD) respiratory disease is currently based on improving mucociliary clearance and controlling infections, through the administration antibiotics. Treatment practices in PCD are largely extrapolated from more common chronic disorders, particularly cystic fibrosis, but no randomized controlled trials (RCT) have ever evaluated efficacy safety any pharmacotherapeutics used treatment PCD. Maintenance therapy, with macrolide antibiotic...
Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathlessness and wheeze yet frequently misdiagnosed as asthma. Insight regarding the demographic characteristics, abnormalities impact EILO currently limited, with data only available from individual centre reports. The aim this work was to provide broader perspective collaboration between multiple international expert centres.Five geographically distinct clinical paediatric adult centres (3 Denmark, 1 UK, USA)...
Cystic fibrosis (CF) care in Denmark has been characterized by close monitoring and pre-emptive treatment of lung disease other CF-related complications. Continuous evaluation through data collection commitment to clinical research incrementally improved outcomes. This approach line with best practices set forth European Standards Care but also gone beyond Society standards particularly pertaining early high-dose combination antimicrobial therapy. Despite a high prevalence severe CF...
Abstract Background Hypersensitivity pneumonitis is a rare interstitial lung disease and very few data regarding frequency, treatment outcome exist for children. Children identified with hypersensitivity pneumonia from Danish national cohort diffuse form the basis of this study focused on treatment, functional outcome. Methods Seventy‐three children clinical radiological signs verified by biopsy were over 12‐year period. Histologic material all cases was reviewed pathologists ChILD Clinical...
Rationale: Elevated fractional exhaled nitric oxide (FeNO) concentration has been suggested to predict early childhood wheeze and sensitization.Objectives: To investigate the association between FeNO in asymptomatic neonates development of patterns atopic intermediary phenotypes first 6 years life.Methods: We measured 253 healthy 1-month-old from Copenhagen Prospective Study on Asthma Childhood birth cohort monitored prospectively wheezy episodes by daily diary cards during life. Total IgE,...
Background: The paranasal sinuses can be a bacterial reservoir for pulmonary infections in patients with cystic fibrosis (CF) METHODOLOGY: In this prospective, non-randomised, uncontrolled, intervention cohort study, the clinical effect of sinus surgery followed by two weeks` intravenous antibiotics, 6 months` antibiotic nasal irrigations was assessed 106 CF patients. Results: One year after surgery, prevalence intermittently colonised had decreased 38%, while non-colonised increased 150%....
Bronchiolitis obliterans (BO) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Lung biopsy the gold standard for diagnosis. This study describes course BO and assesses congruity between biopsy-verified modified version National Institutes Health's consensus criteria syndrome (BOS) based exclusively on noninvasive measures. We included 44 patients transplanted 2000 2010 who underwent lung suspected BO. Of those, 23 were diagnosed with 21 presented other...
We have outlined a new method to measure exhaled nitric oxide on-line at fixed flow rate during controlled tidal breathing (FeNO [controlled]) in young children aged 2 yr and older. FeNO(controlled) measures NO operator-controlled breathing. The operator targets the of child within preset limits 0.4–0.6 L/s by continuously adjusting an expiratory resistance. is estimated end exhalation. validated this against reference single breath (SBOL) maneuvre (FeNO[SBOL]) compared it with mixed air...
Exercise-induced inspiratory symptoms (EIIS) have multiple causes, one of which is exercise-induced laryngeal obstruction (EILO). There limited knowledge regarding EIIS in children, both primary care practices and pediatric asthma clinics. The aim this study was to describe the feasibility a diagnostic methodology its results cohort children with referred our tertiary pulmonary center.This analyzed consecutively collected data from East Denmark Greater Copenhagen during 3½ years period....
Background Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome. Methods A retrospective, descriptive multicentre follow-up study initiated from the European network for translational research in children's adult interstitial lung disease (Cost Action CA16125) chILD-EU CRC (the Research Collaboration Children's Interstitial Lung Disease). Inclusion criteria were DAH of any cause diagnosed before...
Summary Background Nitric oxide in exhaled air is regarded as an inflammation marker, and may be used to monitor the anti‐inflammatory control from inhaled corticosteroids (ICSs). However, this response ICSs exhibits a heterogeneous pattern. Objective The study aimed describe independent variables associated with heterogeneity of nitric ICSs. Methods Exhaled (FeNO), lung function, bronchial hyper‐responsiveness (BHR), specific IgE common inhalant allergens, blood eosinophils, other atopic...