A5000401649- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Infective Endocarditis Diagnosis and Management
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
- Otolaryngology and Infectious Diseases
- Infectious Diseases and Tuberculosis
- Infectious Encephalopathies and Encephalitis
- Orthopedic Infections and Treatments
- Streptococcal Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Bacterial Identification and Susceptibility Testing
- Cystic Fibrosis Research Advances
- Transplantation: Methods and Outcomes
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Immune responses and vaccinations
- Antibiotics Pharmacokinetics and Efficacy
Rigshospitalet
2016-2025
Copenhagen University Hospital
2016-2025
Hvidovre Hospital
1997-2023
Odense University Hospital
2021-2023
Nordsjællands Hospital
2021-2023
Aalborg University
2023
Aarhus University Hospital
2023
Zealand University Hospital
2023
Aalborg University Hospital
2023
Centre of Excellence for Health, Immunity and Infections
2023
Patients with infective endocarditis on the left side of heart are typically treated intravenous antibiotic agents for up to 6 weeks. Whether a shift from oral antibiotics once patient is in stable condition would result efficacy and safety similar those continued treatment unknown.
Abstract The Fifth European Conference on Infections in Leukaemia (ECIL-5) convened a meeting to establish evidence-based recommendations for using tests diagnose Pneumocystis jirovecii pneumonia (PCP) adult patients with haematological malignancies. Immunofluorescence assays are recommended as the most sensitive microscopic method (recommendation A-II). Real-time PCR is routine diagnosis of PCP (A-II). Bronchoalveolar lavage (BAL) fluid best specimen it yields good negative predictive value...
Abstract The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based grading system IDSA. Trimethoprim/sulfamethoxazole given 2–3 times weekly is drug choice primary PCP adults (A-II) and children (A-I) should be during entire period at...
The initiation of systemic antimicrobial treatment Pneumocystis jirovecii pneumonia (PCP) is triggered by clinical signs and symptoms, typical radiological occasionally laboratory findings in patients at risk this infection. Diagnostic proof bronchoalveolar lavage should not delay the start treatment. Most with haematological malignancies present a severe PCP; therefore, therapy be started intravenously. High-dose trimethoprim/sulfamethoxazole choice. In documented intolerance to regimen,...
Brain abscess is a potentially fatal disease. This study assesses clinical aspects of brain in large hospital cohort.Retrospective review adult patients with pyogenic at Rigshospitalet University Hospital, Denmark between 1994 and 2009. Prognostic factors associated Glasgow Outcome Score (GOS) (death, severe disability or vegetative state) were assessed by logistic regression.102 included. On admission, only 20% had triad fever, headache nausea, 39% no 26% normal CRP 49% leucocytosis. Median...
Pneumocystis jirovecii can cause life-threatening pneumonia following treatment for haematological malignancies or after HSCT. The mortality rate of P. (PCP) in these patients is 30%-60%, especially clinical presentation PCP haematology differs from that associated with HIV infection, the disease being acute and more often severe, having a lower fungal burden frequently linked to corticosteroids. Most cases occur not receiving adequate prophylaxis. development new therapies, including...
In the POET (Partial Oral Endocarditis Treatment) trial, oral step-down therapy was noninferior to full-length intravenous antibiotic administration. The aim of present study perform pharmacokinetic/pharmacodynamic analyses for treatments infective endocarditis assess probabilities target attainment (PTAs).Plasma concentrations antibiotics were measured at day 1 and 5. Minimal inhibitory (MICs) determined bacteria causing (streptococci, staphylococci, or enterococci)....
Clinical features applicable to the entire spectrum of viral meningitis are limited, and prognostic factors for adverse outcomes undetermined. This nationwide population-based prospective cohort study included all adults with presumed microbiologically confirmed in Denmark from 2015 until 2020. Prognostic an unfavourable outcome (Glasgow Outcome Scale score 1-4) 30 days after discharge were examined by modified Poisson regression. In total, 1066 episodes included, yielding a mean annual...
ABSTRACT Pneumocystis carinii f. sp. hominis isolates from 207 clinical specimens nine countries were typed based on nucleotide sequence variations in the internal transcribed spacer regions I and II (ITS1 ITS2, respectively) of rRNA genes. The number ITS1 nucleotides has been revised previously reported 157 bp to 161 bp. Likewise, ITS2 changed 177 192 types increased 2 15, that 3 14. 15 are designated A through O, 14 named a n. total 59 P. found this study.
ObjectivesFirst-line therapy for Pneumocystis jirovecii pneumonia (PCP) is trimethoprim/sulfamethoxazole. Few data exist to guide the choice of second-line patients failing or developing toxicity first-line therapy.
While a high risk of nonmelanoma skin cancer is well recognized in solid-organ transplant recipients, the hematopoietic stem-cell (HSCT) recipients has not been extensively studied.To determine cutaneous HSCT and compare it with renal (RTRs) individuals who have received any transplant.A nationwide population-based cohort study from Danish National Hospital Register including 3302 patients underwent (1007 allogeneic, 2295 autologous) 1999 through 2014, 4789 RTRs 1976 10 age- sex-matched...
Knowledge of the epidemiology and clinical characteristics varicella zoster virus (VZV) encephalitis remains limited.Nationwide prospective cohort study adults treated for microbiologically confirmed VZV at Danish departments infectious diseases from 2015 to 2019. Modified Poisson regression analysis was used compute adjusted relative risks (RRs) unfavorable outcome.We identified 92 (49% female) with encephalitis, yielding an incidence 5.3/1 000 per year (95% CI, 4.2-6.6). Median age 75...
Studies on brain abscess are hampered by single-centre design with limited sample size and incomplete follow-up. Thus, robust analyses clinical prognostic factors remain scarce. This Danish nationwide, population-based cohort study included details of all adults (≥18 years) diagnosed in the National Patient Registry from 2007 through 2014 prospective database Study Group Infections Brain covering departments infectious diseases 2015 2020. All patients were followed for 6 months after...
Genotyping at the internal transcribed spacer (ITS) regions of nuclear rRNA operon was performed on isolates P. carinii sp. f. hominis from three clusters pneumonia among eight patients with haematological malignancies and six HIV infection. Nine different ITS sequence types were identified in samples malignancies, suggesting that this cluster cases unlikely to have resulted nosocomial transmission. A common type observed two who shared a hospital room, also infection had prolonged close...
ABSTRACT There is a need to develop noninvasive methods for the diagnosis of Pneumocystis carinii pneumonia in patients unable undergo bronchoscopy or induction sputum. Oral wash specimens are easily obtained, and P. ca- rinii nucleic acid can be amplified demonstrated by PCR. In routine clinical use, easy sample processing single-round PCR needed ensure rapid analysis reduce risk contamination. We developed Touchdown (TD-PCR) protocol with ability detect inhibition specimen. The TD-PCR was...
Recent studies have suggested that infective agents may be involved in the pathogenesis of giant cell arteritis (GCA), particular Chlamydia pneumoniae and parvovirus B19. We investigated temporal arteries from patients with GCA for these infections as well human herpes viruses using polymerase chain reaction (PCR).Thirty artery biopsies 30 suspected having within a period 1 yr were examined. Thirteen had classical GCA, two biopsy-negative 10 polymyalgia rheumatica five other conditions. DNA...
A retrospective study was conducted to describe risk factors associated with Pneumocystis jiroveci pneumonia (PCP) among HIV-negative patients. During 2002-2004, 50 cases of PCP were identified at Rigshospitalet University Hospital on the basis histology, PCR and clinical symptoms PCP. Predisposing conditions included haematological malignancy (72%), inflammatory diseases (14%), solid organ transplantation (6%) other immunodeficiency (8%). The most common treatment related steroid usage...
An outbreak of 29 cases Pneumocystis jirovecii pneumonia (PCP) occurred among renal and liver transplant recipients (RTR LTR) in the largest Danish transplantation centre between 2007 2010, when routine PCP prophylaxis was not used.P. isolates from 22 cases, 2 colonized RTRs, 19 control samples were genotyped by restriction fragment length polymorphism multilocus sequence typing analysis. Contact tracing used to investigate transmission. Potential risk factors compared matched non-PCP...
Epilepsy in patients with brain abscess is frequent, but risk factors and prognosis remain undetermined. This study examined of epilepsy among survivors associated prognosis.Nationwide, population-based healthcare registries were used to compute cumulative incidences cause-specific adjusted hazard rate ratios (adj. HRRs) 95% CIs for 30-day from 1982 through 2016. Data enriched clinical details by medical record review hospitalized 2007 Adjusted mortality MRRs) using as a time-dependent...
Cystic fibrosis (CF) care in Denmark has been characterized by close monitoring and pre-emptive treatment of lung disease other CF-related complications. Continuous evaluation through data collection commitment to clinical research incrementally improved outcomes. This approach line with best practices set forth European Standards Care but also gone beyond Society standards particularly pertaining early high-dose combination antimicrobial therapy. Despite a high prevalence severe CF...