A5086669701- Dermatologic Treatments and Research
- Nonmelanoma Skin Cancer Studies
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- Nail Diseases and Treatments
- Photodynamic Therapy Research Studies
- Laser Applications in Dentistry and Medicine
- Optical Coherence Tomography Applications
- Acne and Rosacea Treatments and Effects
- Advancements in Transdermal Drug Delivery
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Cancer and Skin Lesions
- Hair Growth and Disorders
- Infectious Diseases and Mycology
- Facial Rejuvenation and Surgery Techniques
- Wound Healing and Treatments
- Cervical Cancer and HPV Research
- Hedgehog Signaling Pathway Studies
- Bee Products Chemical Analysis
- Genetic and rare skin diseases.
- Fungal Infections and Studies
- Genital Health and Disease
- Autoimmune Bullous Skin Diseases
Bispebjerg Hospital
2016-2025
Copenhagen University Hospital
2016-2025
University of Copenhagen
2016-2025
Frederiksberg Hospital
2009-2025
Massachusetts General Hospital
2014-2024
Harvard University
2012-2024
Center for Dermatology and Laser Surgery
2021-2023
Wound Healing Society
2020
Capital Region of Denmark
2009-2016
University Hospital of Zurich
2011
Nasty/Rzany An evidence-based guideline has been defined as ‘a systematically developed statement that assists clinicians and patients in making decisions about appropriate treatment for a specific condition’.1 A will never encompass therapy specifications all medical decision-making situations. Deviation from the recommendations may, therefore, be justified This is not textbook on acne, nor complete, all-inclusive reference aspects important to of acne. The presentation safety particular...
Background Photodynamic therapy (PDT) is a highly effective treatment for actinic keratoses (AK); however, it time consuming and often painful the patient. Daylight-PDT would make independent of clinic less due to continuous activation small amounts porphyrins during its formation. Objectives The objective this randomized controlled study was compare response rates adverse effects after methyl aminolevulinate (MAL)-PDT using conventional red light-emitting diode (LED) light vs. daylight....
This is a short summary of the complete version S3 European Acne guideline, please see online appendix for full text (Document S1. Long Version) and detailed methods report (DOI: 10.1111/jdv.13783). Expiry date: 31 December 2020 In order to grade recommendation "standardized guideline" language was used: Recommendations are based on available evidence expert consensus. Available voting lead classification strength recommendation. Adapalene + BPO (f.c.) or Clindamycin e Azelaic acid Topical...
Abstract Background and Objectives Ablative fractional resurfacing (AFR) creates vertical channels that might assist the delivery of topically applied drugs into skin. The purpose this study was to evaluate drug by CO 2 laser AFR using methyl 5‐aminolevulinate (MAL), a porphyrin precursor, as test drug. Materials Methods Two Yorkshire swine were treated with single‐hole subsequent topical application MAL (Metvix®, Photocure ASA, Oslo, Norway), placebo cream no MAL‐induced fluorescence...
Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience clinic attendance discomfort during significant drawbacks. Daylight-mediated PDT could potentially reduce these serve an alternative to conventional PDT.To compare efficacy methyl...
Photodynamic therapy (PDT) is an effective but time-consuming and often painful treatment for actinic keratosis (AK). Home-based daylight-PDT has the potential to facilitate procedure reduce associated pain due continuous activation of small amounts porphyrins. Moreover, a reduced methyl aminolaevulinate (MAL) concentration may inflammation, making more tolerable patients.To compare response rates adverse effects after PDT using conventional 16% 8% MAL with home-based daylight exposure in...
Summary Background Photodynamic therapy (PDT) is an attractive for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight‐mediated PDT a simple tolerable treatment procedure PDT. Methyl aminolaevulinate (MAL)‐PDT approved the of thin or nonhyperkeratotic AKs on face scalp. However, thick AK lesions are often treated as well when present in field‐cancerized area. Objectives In randomized multicentre study to evaluate efficacy daylight‐mediated different severity grades AKs. Methods...
Abstract In addition to approved indications in non‐melanoma skin cancer immunocompetent patients, topical photodynamic therapy ( PDT ) has also been studied for its place the treatment of, as well potential prevent, superficial cancers immune‐suppressed although sustained clearance rates are lower than immune‐competent individuals. using a nanoemulsion of ALA daylight or conventional protocol use field cancerization, evidence prevent new SCC remained limited. High‐quality supports strong...
There is currently intense multidisciplinary interest and a maturing body of literature regarding laser treatments for traumatic scars, but international treatment guidelines reimbursement schemes have not yet caught up with current knowledge practice in many centers. The authors intend to highlight the tremendous potential techniques, offer recommendations safe efficacious treatment, promote wider patient access guided by future high-quality research.An panel 26 dermatologists plastic...
Topical photodynamic therapy (PDT) for actinic keratoses (AK) is hampered by pain during illumination and inferior efficacy in organ-transplant recipients (OTR).We assessed ablative fractional laser (AFL)-assisted daylight (AFL-dPDT) compared with PDT (dPDT), conventional (cPDT) AFL alone (AFL) field treatment of AK OTR.In each patient, four areas the same region were randomized to one AFL-dPDT, dPDT, cPDT AFL. was delivered a 2940-nm at 2·3 mJ per pulse, 1·15 W, two stacks, 50-μs...
The aim of this study was to examine the validity a Danish adaptation Itch Severity Scale (ISS) by exploring associations between pruritus severity, psychological symptoms, and quality life in consecutively recruited sample 20 patients with atopic dermatitis, psoriasis, urticaria, 12 genital pruritus, 11 nephrogenic controls vascular malformations. Convergent discriminative explored analysing ISS total score individual component scores age, sex, diagnosis, disease sleep quality, depressive...
Abstract Raman spectroscopy provides non-destructive, label-free quantitative studies of chemical compositions at the microscale as used on NASA’s Perseverance rover Mars. Such capabilities come cost high requirements for instrumentation. Here we present a centimeter-scale miniaturization spectrometer using cheap non-stabilized laser diodes, densely packed optics, and non-cooled small sensors. The performance is comparable with expensive bulky research-grade systems. It has excellent...
Abstract Background and Objective Burn scars cause permanent disfiguring problems for many patients limited treatments are available. Nonablative fractional lasers induce a wound healing response, which may lead to remodeling of burn scar texture. This randomized trial evaluates efficacy adverse effects 1540 nm laser versus untreated control scars. Materials Methods Seventeen adult with 1 year or older Fitzpatrick skin types I–III were included in the study. Side‐by‐side test areas (i) three...
Abstract Background and Objectives Photodynamic therapy (PDT) of thick skin lesions is limited by topical drug uptake. Ablative fractional resurfacing (AFR) creates vertical channels that may facilitate PDT penetration improve PDT‐response in deep layers. The purpose this study was to evaluate whether pre‐treating the with AFR before topically applied methyl aminolevulinate (MAL) could enable a PDT‐response. Materials Methods Yorkshire swine were treated under general anesthesia CO 2 laser...
Abstract Background The treatment of acne scars with fractional CO 2 lasers is gaining increasing impact, but has so far not been compared side‐by‐side to untreated control skin. Objective In a randomized controlled study examine efficacy and adverse effects laser resurfacing for atrophic no treatment. Methods Patients ( n = 13) in two intra‐individual areas similar sizes appearances were (i) three monthly treatments (MedArt 610; 12–14 W, 48–56 mJ/pulse, 13% density) (ii) Blinded on‐site...
Photodynamic therapy (PDT) is approved for selected nodular basal cell carcinomas (nBCC) but efficacy reduced large and thick tumours. Ablative fractional lasers (AFXL) facilitate uptake of methyl aminolaevulinate (MAL) may thus improve PDT outcome.To evaluate safety AFXL-mediated (AFXL-PDT) compared with conventional high-risk nBCC.Patients histologically verified facial nBCC (n = 32) defined as tumours were included; diameter > 15 mm, located in zones, or on severely sun-damaged skin....
While a high risk of nonmelanoma skin cancer is well recognized in solid-organ transplant recipients, the hematopoietic stem-cell (HSCT) recipients has not been extensively studied.To determine cutaneous HSCT and compare it with renal (RTRs) individuals who have received any transplant.A nationwide population-based cohort study from Danish National Hospital Register including 3302 patients underwent (1007 allogeneic, 2295 autologous) 1999 through 2014, 4789 RTRs 1976 10 age- sex-matched...
Journal Article Intensified fractional CO2 laser‐assisted photodynamic therapy vs. laser alone for organ transplant recipients with multiple actinic keratoses and wart‐like lesions: a randomized half‐side comparative trial on dorsal hands Get access P. Helsing, Helsing Department of Dermatology Oslo University Hospital‐Rikshospitalet N‐0027 Norway Correspondence Per Helsing. E‐mail: phelsing@ous-hf.no Search other works by this author on: Oxford Academic Google Scholar K. Togsverd‐Bo,...