A5061668266- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Infections and bacterial resistance
- Asthma and respiratory diseases
- Mycobacterium research and diagnosis
- Pediatric health and respiratory diseases
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Dysphagia Assessment and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Nematode management and characterization studies
- Complement system in diseases
- Inhalation and Respiratory Drug Delivery
- Chronic Disease Management Strategies
- Immunodeficiency and Autoimmune Disorders
- Family and Patient Care in Intensive Care Units
- Infant Development and Preterm Care
- Delphi Technique in Research
- Child Nutrition and Feeding Issues
- Animal health and immunology
Aarhus University Hospital
2015-2024
Aarhus University
2023
Ghent University
2023
Imation (United States)
2016
University of Liverpool
2011
Medizinische Hochschule Hannover
2010
University of Gothenburg
2007
University Hospital in Motol
2006
Zimmer Biomet (Germany)
2005
Regionshospitalet Herning
2001
Median survival has increased in people with cystic fibrosis (CF) during the past six decades, which led to an number of adults CF. The future impact changes CF demographics not been evaluated. aim this study was estimate children and 34 European countries by 2025. Data were obtained from Cystic Fibrosis Society Patient Registry. Population forecasts performed for that have extensive population coverage at least 4 years longitudinal data modelling entering exiting flows registry cohorts. For...
Pulmonary insufficiency is the main cause of death in cystic fibrosis (CF). We analysed forced expiratory volume 1 s (FEV1) data 14,732 patients registered European Cystic Fibrosis Society Patient Registry (ECFSPR) database 2007. used linear and logistic regressions to investigate associations between FEV1 % predicted clinical outcomes. Body mass index (BMI), chronic infection by Pseudomonas aeruginosa, pancreatic status CF-related diabetes (CFRD) showed a statistically significant (all...
Neutrophils are the main proinflammatory cell type in chronically infected lungs of cystic fibrosis (CF) patients; however, they fail to effectively clear colonizing pathogens. Here, we investigated molecular composition non-mucoid and mucoid Pseudomonas aeruginosa-induced neutrophil extracellular traps (NETs) vitro compared them DNA-protein complexes present CF sputum. The protein P. NET fragments revealed that irrespective inducing stimuli, were decorated with a conserved set proteins....
<h3>Background</h3> Forced expiratory volume in 1 s as a percentage of predicted (%FEV<sub>1</sub>) is key outcome cystic fibrosis (CF) and other lung diseases. As people with CF survive for longer periods, new methods are required to understand the way %FEV<sub>1</sub> changes over time. An up date approach longitudinal modelling presented applied unique dataset demonstrate its utility at clinical population level. <h3>Methods findings</h3> The Danish register contains 70 448 measures on...
To better understand the relative effects of infection with nontuberculous mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we assessed impact each a Danish setting.Longitudinal registry study 432 patients fibrosis contributing 53,771 measures between 1974 2014. We used mixed model longitudinally structured correlation, while adjusting for clinically important covariates.Infections significant rate %FEV1 were Mycobacterium abscessus complex -2.22% points...
The improved survival in people with cystic fibrosis has led to an increasing number of patients reaching adulthood. This trend is likely be maintained over the next decades, suggesting a need increase centres expertise management adult fibrosis. These should capable delivering multidisciplinary care addressing complexity disease, addition psychological burden on and their families. Further issues that require attention are organ transplantation end life management. Lung disease adults...
Abstract This is an extended open study of oral prophylactic treatment with egg yolk antibodies against Pseudomonas aeruginosa , Anti‐Pseudomonas IgY, 17 Swedish patients cystic fibrosis. They have been on IgY for up to 12 years and altogether 114 patient years. A group 23 Danish CF served as control. There has a total absence adverse events. Only 29 cultures positive P. (cultures after chronic colonization not included), that is, 2.3/100 months compared 7.0/100 in the control ( P = 0.028)....
Disease registries have the invaluable potential to provide an insight into natural history of disease under investigation, useful information (e.g. through health indicators) for planning care services and identify suitable groups patients clinical trials enrolment. However, establishment maintenance is a burdensome initiative from economical organisational points view experience sharing on management important avoid waste resources. The aim this paper discuss problems embedded in...
Respiratory infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. Chronic Pseudomonas aeruginosa (PA) infections ultimately occur virtually all It impossible to eradicate PA when a patient has been chronically colonized. Immunotherapy with specific egg-yolk antibodies (IgY) may be an alternative antibiotics for prevention infections. We wanted determine if treatment IgY can prolong period between first second colonization? And long-term, diminish number...
Cystic fibrosis (CF) care in Denmark has been characterized by close monitoring and pre-emptive treatment of lung disease other CF-related complications. Continuous evaluation through data collection commitment to clinical research incrementally improved outcomes. This approach line with best practices set forth European Standards Care but also gone beyond Society standards particularly pertaining early high-dose combination antimicrobial therapy. Despite a high prevalence severe CF...
Patients with cystic fibrosis (CF) often suffer from gastrointestinal (GI) dysfunction including obstructive symptoms, malabsorption and pain, but the underlying pathophysiology remains obscure.To compare GI motility transit times in CF patients healthy controls.Ten (five women, median age 23) pancreatic insufficiency were studied. Total time (GITT) segmental colonic (SCTT) assessed by radiopaque markers. Gastric emptying small intestinal evaluated using magnet-based tracking system (MTS-1)....
Respiratory viral and atypical bacterial infections are associated with pulmonary exacerbations hospitalisations in cystic fibrosis patients. We wanted to study the impact of such on children attending outpatient clinic.Seventy-five were followed for 12 months at regular clinic visits. Routine sputum/laryngeal aspirations tested PCR 7 respiratory viruses. Antibodies against C. pneumoniae, M. pneumoniae B. pertussis measured every 3-4 months. FEV-1, FEF(25-75) specific airway resistance,...
Abstract Aims To explore whether gender differences in the Scandinavian Cystic Fibrosis (CF) patients exist areas of key clinical parameters, complications, and medication. Methods Cross‐sectional data on 890 (416 female) pancreatic insufficient CF were evaluated regarding chronic infection, body mass index, lung function, medication, diabetes, as well Pseudomonas infection status, antibiotic treatment hospitalization from 1‐year follow‐up. Results We found no or frequency diabetes. The...
Abstract Background In Denmark, newborn screening (NBS) for cystic fibrosis (CF) was introduced on 1 May 2016. The implementation and results from the first 2 years of national CF program are presented. Methods included immunoreactive trypsinogen (IRT), followed by evaluation F508del mutation when a value at or above 50 ng/mL cutoff present. cases with single very high IRT 145 ng/mL, next‐generation sequencing transmembrane conductance regulator gene ( CFTR ) performed. Results Of 126 522...