A5031890340- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Down syndrome and intellectual disability research
- Genetics and Neurodevelopmental Disorders
- Kawasaki Disease and Coronary Complications
- Immune Cell Function and Interaction
- Pediatric Urology and Nephrology Studies
- Genomics and Rare Diseases
- Bacterial Infections and Vaccines
- Childhood Cancer Survivors' Quality of Life
- Infectious Encephalopathies and Encephalitis
- Thermal Regulation in Medicine
- Neonatal and Maternal Infections
- Reconstructive Facial Surgery Techniques
- Herpesvirus Infections and Treatments
- Genetic Associations and Epidemiology
- Neonatal Respiratory Health Research
- Thyroid Disorders and Treatments
- Congenital Ear and Nasal Anomalies
- Congenital Heart Disease Studies
- Prenatal Screening and Diagnostics
- Diabetes and associated disorders
Flevoziekenhuis
2010-2025
Abstract Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated being underweight having cardiovascular dysfunction. Objective Our previous trial showed improvement of key clinical biochemical features during 1-year treatment the T3 analogue Triac, but long-term follow-up data are needed. Methods In this real-life retrospective cohort study, we investigated efficacy Triac MCT8-deficient patients 33 sites. The primary...
Background Optimising the use of antibiotics is a key component antibiotic stewardship. Respiratory tract infections (RTIs) are most common reason for prescription in children, even though these children under 5 years viral. This study aims to safely reduce prescriptions with suspected lower RTI at emergency department (ED), by implementing clinical decision rule. Methods and findings In stepped-wedge cluster randomised trial, we included aged 1–60 months presenting fever cough or dyspnoea 8...
Abstract The aim of this study is to evaluate the influence chest X-ray (CXR) results on antibiotic prescription in children suspected lower respiratory tract infections (RTI) emergency department (ED). We performed a secondary analysis stepped-wedge, cluster randomized trial aged 1 month 5 years with fever and cough/dyspnoea 8 EDs Netherlands (2016–2018), including 1-week follow-up. analysed observational data pre-intervention period, using multivariable logistic regression CXR result...
Evaluation of guidelines in actual practice is a crucial step guideline improvement. A retrospective evaluation the Dutch for children with fever without an apparent source (FWS) showed 50% adherence young infants. We prospectively evaluated to and its impact on management current practice. Prospective observational multicenter cross-sectional study, including 3 days 16 years old presented FWS at one seven emergency departments participating secondary tertiary care hospitals Netherlands....
The etiology of childhood meningoencephalitis has changed significantly over the past decades with introduction national immunization programs against previous common causes meningoencephalitis.1–5 Pathogens that are not included in these vaccination (Escherichia coli, group B streptococci, enteroviruses and herpes simplex viruses) now considered leading meningoencephalitis.6–10 Despite significant decrease total incidence following effective programs, morbidity mortality rates remain high...
Background: Children with fever and respiratory symptoms represent a large patient group at the emergency department (ED). A decision rule-based treatment strategy improved targeting of antibiotics in these children recent clinical trial. This study aims to evaluate impact rule on healthcare societal costs, describe costs suspected lower tract infections (RTIs) ED general. Methods: In stepped-wedge, cluster randomized trial, we collected cost data 1 month 5 years age cough/dyspnea 8 EDs The...
<title>Abstract</title> Purpose Evaluation of guidelines in actual practice is a crucial step guideline improvement. Retrospective evaluation the Dutch for children with fever without an apparent source (FWS) showed 50% adherence young infants. We prospectively evaluated to and its impact on management current practice. Methods Prospective observational multicenter study, including three days sixteen years old presented FWS at one seven Emergency Departments participating secondary tertiary...
Abstract The total uptake of prenatal aneuploidy screening for Down syndrome (DS) is increasing worldwide. As a result diagnosis DS and subsequent termination pregnancy, livebirth prevalence decreasing. aim this study to explore the impact an on neonatal mortality morbidity in DS. This retrospective cohort 253 neonates with born between 2012 2018 that were seen at outpatient clinic five hospitals Netherlands. medical files reviewed maternal characteristics morbidities. Dutch national birth...