A5074286172- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Emergency and Acute Care Studies
- Chronic Lymphocytic Leukemia Research
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Platelet Disorders and Treatments
- DNA Repair Mechanisms
- Coronary Artery Anomalies
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Antibiotic Use and Resistance
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Melanoma and MAPK Pathways
- RNA and protein synthesis mechanisms
Reinier de Graaf Hospital
2009-2023
Nederlandse Vereniging voor Kindergeneeskunde
2022
Radboud University Nijmegen
2002-2010
Radboud University Medical Center
2002-2010
Stellenbosch University
2008
Erasmus MC
2002-2007
Leiden University Medical Center
2002
University of Bydgoszcz
2002
Erasmus University Rotterdam
1997-2002
Erasmus MC - Sophia Children’s Hospital
1999-2000
Type 1 diabetes results from an immune-mediated destruction of pancreatic beta cells. The disease can be transmitted by bone marrow transplantation in humans1 and animals.2,3 Furthermore, T cells that are reactive to several islet autoantigens have been identified both mice humans.4,5 Although it is generally accepted a role during the process, possible B autoantibodies type humans has not fully resolved. When they activated, produce beta-cell antigens — such as glutamic acid decarboxylase...
The major part of the TCR-delta locus is flanked by so-called TCR-delta-deleting elements deltaRec and psi(J)alpha, which preferentially rearrange to each other in human thymocytes. On basis our combined Southern blot PCR analyses, we also identified prominent deltaRec-Jalpha58 rearrangement three preferential rearrangements. latter rearrangements concern Ddelta3, Jdelta1, Jdelta3 gene segments. These do not delete complete are homologous Vdelta-Jdelta rearrangements, because majority their...
Abstract Although the incidence of TB has stabilized or declined in most world regions, it is increasing Africa, Southeast Asia, and Eastern Mediterranean, fuelled by HIV pandemic. More than 4,000 people died daily from TB‐related illnesses 2005. a major cause childhood morbidity mortality these developing countries, there an urgent need for rapid definitive modalities mycobacterial diagnosis children. This prospective study Tygerberg Hospital, Cape Town, South evaluates ability fine needle...
Ataxia-telangiectasia (A-T) is characterised by progressive neurological abnormalities, oculocutaneous telangiectasias and immunodeficiency (decreased serum IgG subclass and/or IgA levels lymphopenia). However, 10% of A-T patients present with decreased normal or raised IgM levels. As cerebellar ataxia are not at very young age, these often erroneously diagnosed as hyper syndrome (HIGM). Eight A-T, showing Ig suggestive HIGM on first presentation, described. All had numbers T lymphocytes,...
The imposition of lockdowns during the severe acute respiratory syndrome coronavirus-2 pandemic led to a significant decrease in pediatric care utilization 2020. After restrictions were loosened, surge disease was observed wards. aim this study quantify effect lockdown(s) on incidence disease.For multicenter retrospective study, emergency department (ED) visit and admission data between January 2017 September 2021 collected from eight general hospitals Netherlands. Clinical diagnoses...
Children with SARS-CoV-2 related Multisystem Inflammatory Syndrome in (MIS-C) often present clinical features that resemble Kawasaki disease (KD). Disease severity adult COVID-19 is associated to the presence of anti-cytokine autoantibodies (ACAAs) against type I interferons. Similarly, ACAAs may be implicated KD and MIS-C. Therefore, we explored immunological response, correlates both disorders.Eighteen inflammatory plasma protein levels seven were measured (n = 216) MIS-C 56)...
Background Optimising the use of antibiotics is a key component antibiotic stewardship. Respiratory tract infections (RTIs) are most common reason for prescription in children, even though these children under 5 years viral. This study aims to safely reduce prescriptions with suspected lower RTI at emergency department (ED), by implementing clinical decision rule. Methods and findings In stepped-wedge cluster randomised trial, we included aged 1–60 months presenting fever cough or dyspnoea 8...
Background Kawasaki disease ( KD ) is a pediatric vasculitis with coronary artery aneurysm CAA as major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether patients are at increased risk, assessed by carotid intima‐media thickness cIMT ). Methods and Results We measured over 15 years B‐mode ultrasonography during follow‐up unaffected controls (mostly siblings). A multilevel, repeated‐measures, linear mixed‐effects model used...
Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-gamma receptor 1 chain. Such hamper activation of macrophages a type immune response and result enhanced survival intracellular pathogens. We here report two patients with unusual infections, both diagnosed homozygous gene mutations. Patient became ill after Bacillus Calmette-Guérin vaccination at age 9 months died 18 months. She carried C71Y mutation extracellular...
Abstract The aim of this study is to evaluate the influence chest X-ray (CXR) results on antibiotic prescription in children suspected lower respiratory tract infections (RTI) emergency department (ED). We performed a secondary analysis stepped-wedge, cluster randomized trial aged 1 month 5 years with fever and cough/dyspnoea 8 EDs Netherlands (2016–2018), including 1-week follow-up. analysed observational data pre-intervention period, using multivariable logistic regression CXR result...