A5022968447- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Adolescent and Pediatric Healthcare
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- Genetic Associations and Epidemiology
- Lung Cancer Research Studies
- Neonatal Health and Biochemistry
- Genomics and Rare Diseases
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Gestational Diabetes Research and Management
- Pediatric Hepatobiliary Diseases and Treatments
John Hunter Children's Hospital
2018-2025
University of Newcastle Australia
2018-2025
Hunter Medical Research Institute
2020-2025
St Vincent's Hospital
2025
The University of Western Australia
2021
Abstract Aims To determine if the frequency of severe diabetic ketoacidosis at presentation new‐onset type 1 diabetes to an Australian tertiary centre increased during initial period restrictions resulting from COVID‐19 pandemic (March May 2020). Methods Data were collected on presentations newly diagnosed as well all paediatric emergency department a between 2015 and 2020. COVID in Australia 2020) compared March previous 5 years (pre‐pandemic periods). Results The number new diagnoses was...
Abstract Predicting and quantifying phenotypic consequences of genetic variants in rare disorders is a major challenge, particularly pertinent for ‘actionable’ genes such as thyroid hormone transporter MCT8 (encoded by the X-linked SLC16A2 gene), where loss-of-function (LoF) cause neurodevelopmental (treatable) metabolic disorder males. The combination deep phenotyping data with functional computational tests outcomes population cohorts, enabled us to: (i) identify aetiology divergent...
Introduction Young children with type 1 diabetes (T1D) consume more saturated fat and less fruit vegetables than recommended. A common challenge in this age group is unpredictable appetite potentially impacting the way parents manage cares at mealtimes. This small study aimed to assess nutritional intake mealtime routines of young T1D a clinic where majority were achieving glycemic targets. secondary aim was explore association eating pattern HbA1c. Methods retrospective, cross-sectional...
OBJECTIVE To compare glucose control with hybrid closed-loop (HCL) when challenged by high intensity exercise (HIE), moderate (MIE), and resistance (RE) while profiling counterregulatory hormones, lactate, ketones, kinetic data in adults type 1 diabetes. RESEARCH DESIGN AND METHODS This study was an open-label multisite randomized crossover trial. Adults diabetes undertook 40 min of HIE, MIE, RE random order using HCL (Medtronic MiniMed 670G) a temporary target set 2 h prior to during 15 g...
Abstract Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated being underweight having cardiovascular dysfunction. Objective Our previous trial showed improvement of key clinical biochemical features during 1-year treatment the T3 analogue Triac, but long-term follow-up data are needed. Methods In this real-life retrospective cohort study, we investigated efficacy Triac MCT8-deficient patients 33 sites. The primary...
Introduction: Physical activity has health benefits for people living with type 1 diabetes (T1D), however there are barriers limiting their ability to meet minimum recommended levels of moderate-to-vigorous-physical-activity (MVPA). We aimed measure physical and in children < 7 years age T1D compare general population data guidelines. Methods: Children were recruited from two paediatric centres Australia. was measured days using an accelerometer. Parents completed questionnaires related...
Aim: To compare evening and overnight hypoglycemia risk after late afternoon exercise with a nonexercise control day in adults type 1 diabetes using automated insulin delivery (AID). Methods: Thirty AID (Minimed 670G) performed random order 40 min high intensity interval aerobic (HIE), resistance (RE), moderate (MIE) each separated by >1 week. The closed-loop set-point was temporarily increased 2 h pre-exercise snack eaten if plasma glucose ≤126 mg/dL pre-exercise. Exercise commenced at...
To determine if the relationship between meal carbohydrate quantity and insulin to ratio (ICR) required maintain glycaemia is linear in people with type 1 diabetes.We used an open labelled randomized four-arm cross-over study design. Participants (N = 31) aged 12-27 years, HbA1c ≤ 64 mmol/mol (8.0%) received doses based on individual's ICR breakfast then consumed four breakfasts containing 20, 50, 100 150 g of over consecutive days order. The fat protein percentages were standardized....
Glycemic control in the young child with type 1 diabetes (T1D) has traditionally been challenging. Unpredictability appetite and dietary intake made achievement of glycemic targets difficult. This study aimed to assess nutritional quality behaviors children T1D that attend a clinic meets this age group. Carers aged &lt;7 years attending specialist Pediatric Diabetes Service Australia completed 3 day food diary survey regarding management behaviours. Twenty one participated (mean age: 4.7...
<b>Objective</b>: To compare glucose control with hybrid closed loop (HCL) when challenged by moderate-intensity exercise (MIE), high-intensity intermittent (HIE) and resistance (RE) while profiling counter-regulatory hormones, lactate, ketones, kinetic data in adults type 1 diabetes. <p><b>Methods</b>: <a>Open-label multisite randomized crossover trial. </a><a>Adults diabetes undertook 40 min of HIE, MIE, RE random order using HCL (Medtronic...
Introduction: Caring for young children with Type 1 diabetes comes significant burden parents. We hypothesised that pregnancy and the arrival of a new sibling may be associated deterioration in control type older siblings diabetes. Research Design Methods: identified currently under care John Hunter Children's Hospital Paediatric Diabetes team who had welcomed younger since their diagnosis using our prospective database. reviewed HbA1c pre post sibling. Results: 38 (20 male) become 5 were...
Background: Hybrid closed loop (HCL) systems may mitigate the glycemic impact of different exercise types in youth with type 1 Diabetes. Aims: Glucose was compared during and following moderate intensity (MIE), high interval (HIE) resistance (RE) adolescents using HCL insulin delivery. Methods: Adolescents (Medtronic Minimed 670G) undertook 40 min MIE, HIE RE random order. A temporary glucose target set 2 hours prior 15g carbohydrate given pre-exercise if level &lt;126mg/dL. standardized...
<b>Objective</b>: To compare glucose control with hybrid closed loop (HCL) when challenged by moderate-intensity exercise (MIE), high-intensity intermittent (HIE) and resistance (RE) while profiling counter-regulatory hormones, lactate, ketones, kinetic data in adults type 1 diabetes. <p><b>Methods</b>: <a>Open-label multisite randomized crossover trial. </a><a>Adults diabetes undertook 40 min of HIE, MIE, RE random order using HCL (Medtronic...
<b>Objective</b>: To compare glucose control with hybrid closed loop (HCL) when challenged by moderate-intensity exercise (MIE), high-intensity intermittent (HIE) and resistance (RE) while profiling counter-regulatory hormones, lactate, ketones, kinetic data in adults type 1 diabetes. <p><b>Methods</b>: <a>Open-label multisite randomized crossover trial. </a><a>Adults diabetes undertook 40 min of HIE, MIE, RE random order using HCL (Medtronic...