A5022738277- Cystic Fibrosis Research Advances
- Infections and bacterial resistance
- Tracheal and airway disorders
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
- Infant Development and Preterm Care
- Pediatric health and respiratory diseases
- Mycobacterium research and diagnosis
- Pancreatitis Pathology and Treatment
- Respiratory Support and Mechanisms
- Antibiotic Use and Resistance
- Cerebrospinal fluid and hydrocephalus
- Ovarian function and disorders
- Microbial Applications in Construction Materials
- Airway Management and Intubation Techniques
- Tuberculosis Research and Epidemiology
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Bioinformatics and Genomic Networks
- Participatory Visual Research Methods
Skåne University Hospital
2019-2025
Lund University
2021-2025
American Academy of Sleep Medicine
2024
RWTH Aachen University
2023
Washington Center
2021
Rigshospitalet
2005-2015
Copenhagen University Hospital
2006-2014
Hôpital des Enfants
2012
UF Health Shands Hospital
2011
University of Florida
2011
The present study was undertaken to investigate the appearance and location of Pseudomonas aeruginosa in cystic fibrosis (CF) lung sputum. Samples include preserved tissues CF patients who died due chronic P. infection prior advent intensive antibiotic therapy, explanted lungs from 3 intensively treated chronically infected routine sputum 77 patients. All samples were investigated microscopically using hematoxylin-eosin (HE), Gram alcian-blue stain, PNA FISH immunofluorescence for...
Chronic lung infection with Pseudomonas aeruginosa is the most severe complication for patients cystic fibrosis (CF). This characterised by endobronchial mucoid biofilms surrounded numerous polymorphonuclear leucocytes (PMNs). The phenotype offers protection against PMNs, which are in general assumed to mount an active respiratory burst leading tissue deterioration. An ongoing PMNs has, however, not been demonstrated previously secretions from chronically infected CF.Based on accumulating...
To better understand the relative effects of infection with nontuberculous mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we assessed impact each a Danish setting.Longitudinal registry study 432 patients fibrosis contributing 53,771 measures between 1974 2014. We used mixed model longitudinally structured correlation, while adjusting for clinically important covariates.Infections significant rate %FEV1 were Mycobacterium abscessus complex -2.22% points...
Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.In this retrospective observational study we identified all Scandinavian CF with a positive NTM culture from airway secretions 2000 the end of 2012 and used national databases describe microbiological clinical characteristics.During 13-year period 157 (11%) were for at least once. Mycobacterium abscessus complex (MABSC) (45%) avium (MAC) (32%) predominant...
Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship diagnostic findings clinical phenotypes.
Achromobacter xylosoxidans is an environmental opportunistic pathogen, which infects increasing number of immunocompromised patients. In this study we combined genomic analysis a clinical isolated A. strain with phenotypic investigations its important pathogenic features. We present complete assembly the genome NH44784-1996, isolate from cystic fibrosis patient obtained in 1996. The NH44784-1996 contains approximately 7 million base pairs 6390 potential protein-coding sequences. identified...
Chronic lung infection by Pseudomonas aeruginosa is the major severe complication in cystic fibrosis (CF) patients, where P. persists and grows biofilms endobronchial mucus under hypoxic conditions. Numerous polymorphonuclear leukocytes (PMNs) surround create local anoxia consuming majority of O2 for production reactive oxygen species (ROS). We hypothesized that acquires energy growth anaerobic denitrification, which can be demonstrated nitrous oxide (N2O), an intermediate denitrification...
Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is characterized by persisting mucoid biofilms hypoxic endobronchial mucus. These are surrounded numerous polymorphonuclear leucocytes (PMNs), which consume a major part of present molecular oxygen (O(2)) due to production superoxide (O(2)(-)). In this study, we show that the PMNs also O(2) for nitric oxide (NO) synthases (NOS) infected Fresh expectorated sputum samples (n = 28) from chronically CF 22) were...
In the present work, a technique for establishing multiple black lipid membranes (BLMs) in arrays of micro structured ethylene tetrafluoroethylene (ETFE) films, and supported by porous material was developed. Rectangular 8 × with apertures having diameters 301 ± 5 µm were fabricated ETFE Teflon film laser ablation using carbon dioxide laser. Multiple could be formed across array partitions. Success rates establishment cellulose-supported BLMs aperture above 95%. However, time course membrane...
Cystic fibrosis (CF) care increasingly demands flexible and personalised approaches, particularly with the growing role of telemedicine in disease management. This study aimed to evaluate use home-based spirometry antibiotic monitoring for assessing lung function trends treatment patterns individuals CF. Individuals aged 0-25 years from seven Swedish CF centres participated 12 months routine care, digitally recording usage performing home (aged ≥5 years). Home sessions were graded according...
Abstract Objectives Cystic fibrosis hepato‐biliary involvement (CFHBI) is a common comorbidity in patients with CF and associated increased morbidity mortality. The effect of the new highly potent transmembrane conductance regulator modulator therapy, elexacaftor–tezacaftor–ivacaftor (ETI), on CFHBI, still unclear. This study aimed to investigate impact ETI liver stiffness children CF, as measured using two‐dimensional (2D) shear wave elastography (SWE). Methods Twenty‐one were included this...
Abstract Objectives Telehealth and home spirometry feasibility for children has been established, but their impact on cystic fibrosis (CF) disease progression remains unassessed. We aimed to evaluate the effects of telehealth CF care. Methods Children with aged 5–17 years from all Swedish centers were provided spirometers. A minimum two in‐person visits replaced telemedicine participants instructed conduct before visits. Linear mixed‐effects models used compare annual trajectories during...