A5015759708- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Genetic and Kidney Cyst Diseases
- Air Quality Monitoring and Forecasting
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Blood Pressure and Hypertension Studies
- Cerebrospinal fluid and hydrocephalus
- Global Health Care Issues
- Dysphagia Assessment and Management
- COVID-19 and Mental Health
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Urban Transport and Accessibility
- Health, Environment, Cognitive Aging
- Physical Activity and Health
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Radioactivity and Radon Measurements
University of Cyprus
2018-2025
University of Copenhagen
2024
Cyprus University of Technology
2014-2023
Archbishop Makarios III Hospital
2023
Cyprus Institute of Neurology and Genetics
2016
University of Ioannina
2014
Cyprus Institute
2014
Nasal nitric oxide (nNO) is extremely low in most people with primary ciliary dyskinesia (PCD) and its measurement an important contributor to making the diagnosis. Existing guidelines technical standards focus on nNO measurements older, cooperative children using chemiluminescence analysers. However, of pre-school-age (age 2–5 years) may facilitate early diagnosis electrochemical rather than analysers are widely used. Pre-schoolers often need different methods be employed when measuring...
Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting energy requirements of cells through respiratory chain located inner mitochondrial membrane, concomitant with generation reactive oxygen species (ROS). A wealth evidence derived from contemporary investigations on reproductive longevity strongly indicates that aberrant elevation ROS level constitutes fundamental factor hastening aging process systems which are responsible...
Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship diagnostic findings clinical phenotypes.
Prematurity and low birth weight are significant predictors of perinatal morbidity mortality influenced by the overall health socioeconomic status pregnant mother. Although Cyprus is characterized highest prematurity rate in Europe (13.1% 2014), relationship between maternal characteristics with has never been investigated. We aimed to investigate association demographic, clinical premature delivery neonatal Cyprus.In a case-control design, questionnaire data were collected from 348 women...
Elevated particulate matter (PM) concentrations of anthropogenic and/or desert dust origin are associated with increased morbidity among children asthma.
Regular active commuting, such as cycling and walking to from the workplace, is associated with lower all-cause mortality through increased physical activity (PA). However, commuting may increase intake of fine particles (PM2.5), causing negative health effects. The purpose this study estimate combined risk PA air pollution for among commuters who, on days high PM2.5 levels, switch by public transportation or work home. Towards purpose, we developed a Health Impact Assessment model six...
Abstract Background Late-onset neonatal sepsis (LOS) is common in preterm neonates, with increasing incidence recent years. In the present study, we examined epidemiology, clinical presentation, and complications of LOS Cyprus quantified possible risk factors for development this condition. Methods The study subjects were neonates admitted Neonatal Intensive Care Unit (NICU) Archbishop Makarios III Hospital, only tertiary centre Cyprus. A prospective, case-control was designed, carried out...
Polymorphisms in the vitamin D receptor (VDR) gene have been studied immune-related disorders either as independent contributors or combination with concentration. Vitamin and VDR independently linked to asthma susceptibility. We investigated whether variants were associated relation levels Cypriot adolescents.We 190 current wheezers, 69 of which categorized active asthmatics 671 healthy controls. determined three genotypes (BsmI, TaqI, ApaI) measured serum 25(OH)D levels. Logistic...
Non-invasive cardiovascular disease (CVD) risk prediction, in subclinical stages, aiming to stratify patients and tailor interventions remains an unmet need chronic kidney (CKD). In this meta-analysis, we summarize the association of carotid intima-media thickness (cIMT), coronary artery calcium score (CACS) pulse wave velocity (PWV) with all-cause mortality, (CV) mortality CV events non-dialysis CKD on haemodialysis.Systematic review meta-analysis prospective cohort studies.Out 27 984...
Abstract Background Cyprus is undergoing a major health reform with the recent establishment of General Healthcare System (GHS). The GHS offers equal healthcare access through one primary insurer (Health Insurance Organization [HIO]) and benefits from wide collaborative network public private providers. However, unwanted variation in practice makes this transition challenging. guidelines could decrease these variations practice, but lacks capacity to develop them de novo. Through...
Background The extent to which changes in lung function are due natural variability patients with primary ciliary dyskinesia (PCD) is unknown. We aimed assess intra-individual forced expiratory volume 1 s (FEV ) derived from spirometry define the observed were test clinically stable PCD patients. Methods PROVALF-PCD a large international prospective cohort conducted 2017–2019. included ≥5 years who ≥2 consecutive visits and provided spirometry-derived measurements. To calculate upper limit...
Introduction: Cyprus is located in the Eastern Mediterranean and heavily exposed to desert dust storm (DDS) events, which diminish air quality adversely impact paediatric asthma morbidity. School health visitors (SHVs) play a key role management schoolchildren are pivotal for development of school‐based intervention programs. Objectives: This study aimed examine knowledge, practices perceptions SHVs on management. Additionally, we sought determine factors associated with SHVs’ level...
Abstract Background The high variety of mutations found in the Cystic Fibrosis Transmembrane Regulator ( CFTR ) gene is responsible for clinical heterogeneity observed people with (CF) and atypical manifestations CFTR-related disorders (CFTR-RD). intronic c.489+3A>G (c.621+3A>G) variant has been reported to have questionable pathogenicity, although its alleged severity was probably due co-segregation cis another undetected mutation, as previously from countries Mediterranean region. In...
Abstract Background Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung PCD across countries compared disease course lobectomised non-lobectomised patients. Methods In international iPCD cohort, we identified age sex-matched patients their characteristics, function BMI cross-sectionally longitudinally. Results Among 2896 163 from 20 centers (15 countries) underwent (5.6%). adult patients, was 8.9%,...
Abstract Between March and April 2020, Cyprus Greece health authorities enforced three escalated levels of public interventions to control the COVID-19 pandemic. We quantified compliance 108 asthmatic schoolchildren (53 from Cyprus, 55 Greece, mean age 9.7 years) both countries intervention levels, using wearable sensors continuously track personal location physical activity. Changes in ‘fraction time spent at home’ ‘total steps/day’ were assessed with a mixed-effects model adjusting for...