A5046005959- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Pelvic and Acetabular Injuries
- Chronic Myeloid Leukemia Treatments
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Adolescent and Pediatric Healthcare
- Cystic Fibrosis Research Advances
- Lymphoma Diagnosis and Treatment
- Simulation-Based Education in Healthcare
- Statistical Methods and Inference
- Preterm Birth and Chorioamnionitis
- Maternal Mental Health During Pregnancy and Postpartum
- Asthma and respiratory diseases
- Cancer survivorship and care
- Bladder and Urothelial Cancer Treatments
- Nutritional Studies and Diet
- Maternal and Perinatal Health Interventions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pregnancy-related medical research
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Ectopic Pregnancy Diagnosis and Management
- Pneumonia and Respiratory Infections
- Patient Safety and Medication Errors
Danish Cancer Society
2022-2025
University of Copenhagen
2015-2024
Copenhagen University Hospital
2012-2024
Rigshospitalet
2012-2024
University College London
2016
Great Ormond Street Hospital
2016
Børnecancerfonden
2016
Holbæk Sygehus
2016
Copenhagen Academy for Medical Education and Simulation
2016
Nordsjællands Hospital
2016
This paper deals with the competing risks model as a special case of multi-state model. The properties are reviewed and contrasted to so-called latent failure time approach. relation between right-censoring is discussed regression analysis cumulative incidence function briefly reviewed. Two real data examples presented guide practitioner given.
Objective To investigate the effect of in situ simulation (ISS) versus off-site (OSS) on knowledge, patient safety attitude, stress, motivation, perceptions simulation, team performance and organisational impact. Design Investigator-initiated single-centre randomised superiority educational trial. Setting Obstetrics anaesthesiology departments, Rigshospitalet, University Copenhagen, Denmark. Participants 100 participants teams 10, comprising midwives, specialised auxiliary nurses, nurse...
To target psychological support to cancer patients most in need of support, screening for distress has been advocated and, some settings, also implemented. Still, no prior studies have examined the appropriate 'dosage' and whether before treatment may be sufficient or if further screenings during are necessary. We development symptom trajectories breast with low surgery explored potential risk factors developing burdensome symptoms at a later point time. In total, 299 newly diagnosed who...
Thioguanine nucleotides (TGNs) mediate the cytotoxicity of mercaptopurine (MP). Methylated MP metabolites (formed by thiopurine methyltransferase [TPMT]) and methotrexate (MTX) polyglutamates can inhibit de novo purine synthesis. We explored whether dose adjustment MTX erythrocyte (E) levels TGN (including polyglutamates) could improve outcome in childhood acute lymphoblastic leukemia (ALL).A total 538 children with ALL were randomly assigned to have their oral MP/MTX maintenance therapy...
To explore the effect of adding simulation-based transvaginal ultrasound training to trainees' clinical compared with only on quality and efficiency care.Simulation-based may be an effective adjunct training, but no studies have examined its effects care.Trainees from 4 University Hospitals in East Denmark were included (N = 54). Participants randomized either (intervention group, n 28), or (control 26).The primary outcome was patient-reported discomfort during examinations performed by...
Background Low back pain is highly prevalent among pregnant women, but evidence of an effective treatment are still lacking. Supervised exercise–either land or water based–has shown benefits for low pain, no trial has investigated the unsupervised exercise program on pain. We aimed to assess effect intensity and days spent sick leave healthy women. Methods In this randomised, controlled, parallel-group trial, 516 women were randomly assigned either twice a week period 12 weeks standard...
Commonly used antihistamines and other cationic amphiphilic drugs (CADs) are emerging as putative cancer drugs. Their unique chemical structure enables CADs to accumulate rapidly inside lysosomes, where they increase lysosomal pH, alter lipid metabolism, eventually cause membrane permeabilization. Here, we show that CAD-induced rapid elevation in pH is caused by a H+ efflux requires P2RX4-mediated Ca2+ release precedes the The subsequent cytosolic acidification triggers dephosphorylation,...
Laparoscopic simulation has become a standard component of surgical training, but there is limited knowledge regarding skills transfer between procedural tasks. The objective was to investigate the specificity simulator training.This randomized single-centre educational superiority trial. Surgical novices practised basic on laparoscopic virtual reality simulator. On reaching proficiency, participants were proficiency-based training. intervention group two procedures (appendicectomy followed...
To evaluate the usefulness of first-trimester crown-rump length (CRL) discordance in predicting adverse outcome twin pregnancies.This retrospective study included a large cohort retrieved from local ultrasound databases at 14 obstetric departments Denmark, comprising all pregnancies with two live fetuses scanned between 11 and weeks' gestation during period 1 January 2004 to 31 December 2006. The association CRL ≥ 10 % was evaluated.Among 1993 pregnancies, 1733 were dichorionic (156 (9%)...
Abstract PCR of TCR/Ig gene rearrangements is considered the method choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis leukemia-associated immunophenotypes (FCM-MRD) faster and biologically more informative. FCM-MRD performed 18 laboratories across seven countries was used risk stratification 1487 patients with BCP-ALL enrolled NOPHO ALL2008 protocol. When no informative FCM-marker available, based on real-time quantitative PCR. An found 96.2%...
Purpose: To examine clinimetric properties of the de Morton Mobility Index (DEMMI) in patients with hip fracture comparison modified Barthel (BI), Cumulated Ambulation Score (CAS), and 30-s Chair Stand Test (30-s CST).Materials methods: Two hundred twenty two a admitted to geriatric ward following surgery were assessed on day 1 at discharge (mean 9 [SD 5.1] post-surgery days).Results: Ninety eight percent 89% not able perform CST baseline (large floor effect), respectively. Corresponding...
ABSTRACT Objectives To assess cervical length (CL) longitudinally between the first and second trimesters to determine proportion of women with short CL. The study also aimed if CL at 19–24 weeks' gestation could be identified time combined first‐trimester screening (cFTS) 11–14 gestation, in order potential value implementation for prediction preterm delivery a Danish population. Methods This was prospective longitudinal singleton pregnancy attending three University Hospitals Denmark from...
Nasal nitric oxide (NO) discriminates between patients with primary ciliary dyskinesia (PCD) and healthy individuals. We report feasibility of measurement natural evolution nasal NO upon the impact respiratory tract infection (RTI) on in infants (HI), followed from birth until age 2 years, comparison to infant PCD. Tidal-breathing measurements were performed at scheduled visits weeks old 4, 8, 12, 18 24 months old, extra during RTIs. Historical for PCD included comparison. Altogether, 224 44...