A5024957067- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Adolescent and Pediatric Healthcare
- Parvovirus B19 Infection Studies
- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- Research in Social Sciences
- Neuroblastoma Research and Treatments
- Family Support in Illness
- Glioma Diagnosis and Treatment
- Testicular diseases and treatments
- Polyomavirus and related diseases
- Renal and related cancers
- Neutropenia and Cancer Infections
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Clinical Nutrition and Gastroenterology
- Bone and Joint Diseases
- Bone health and treatments
Helsinki University Hospital
2016-2025
University of Helsinki
2016-2025
Helsinki Children's Hospital
2001-2023
Children's Hospital
2008-2021
Children's Research Hospital
2019
St. Jude Children's Research Hospital
2016
University College London
2016
Sheffield Children's Hospital
2016
Great Ormond Street Hospital
2016
University of Pavia
2016
The prognosis of acute lymphoblastic leukemia is poorer in adults than children. Studies have indicated that young benefit from pediatric treatment, although no upper age limit has been defined.We analyzed 749 patients aged 1-45 yr treated by the NOPHO ALL-2008 protocol. Minimal residual disease (MRD) on days 29 and 79, immunophenotype, white blood cell count (WBC), cytogenetics were used to stratify standard-, intermediate-, or high-risk treatment with without hematopoietic stem...
The prognostic impact of the tumor microenvironment in diffuse large B-cell lymphoma has not been systematically assessed. We analyzed mRNA and antigen expression monocytes, macrophages, lymphocytes, dendritic natural killer cells pretreatment samples patients with high-risk using gene microarray immunohistochemistry. were treated a Nordic phase II study dose-dense chemoimmunotherapy central nervous system prophylaxis. Of studied markers for non-malignant inflammatory cells, CD68 CD68+...
Abstract Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade the treatment choice for vasculopathy, but often fails to reverse refractory cytopenia. We aimed study...
L-asparaginase is an important drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Treatment associated with several toxicities, including pancreatitis. Clinical course, presentation, re-exposure to L-asparginase after pancreatitis and risk recurrent within asparaginase-intensive protocol has been poorly reported. Children (1–17 years) on ongoing Nordic Society Paediatric Haematology Oncology (NOPHO) ALL2008 asparaginase-associated (AAP) diagnosed between 2008 2012 were...
PURPOSE Asparaginase-associated pancreatitis (AAP) is common in patients with acute lymphoblastic leukemia (ALL), but risk differences across age groups both relation to first-time AAP and after asparaginase re-exposure have not been explored. PATIENTS AND METHODS We prospectively registered (n = 168) during treatment of 2,448 consecutive ALL aged 1.0-45.9 years diagnosed from July 2008 October 2018 treated according the Nordic Society Pediatric Hematology Oncology (NOPHO) ALL2008 protocol....
Abstract Cartilage‐hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia with short stature, sparse hair and defective cell‐mediated immunity. It caused by mutations in the RMRP (ribonuclease mitochondrial RNA processing) gene, encoding component of ribonuclease complex RNase MRP. The aim this study was to further elucidate risk spectrum cancer CHH. A cohort 123 Finnish patients CHH (51 males) followed for malignancy through Cancer Registry. number identified cancers compared...
Background. Patients diagnosed with osteosarcoma in Finland during 1991–2005 were retrospectively analyzed a nationwide, population-based study. We focused on the incidence, treatment and outcome of patients. also evaluated value known prognostic parameters. Material methods. Osteosarcomas retrieved from files national Finnish Cancer Registry. Only patients histologically confirmed included analysis. Histological review was performed. Results. The study consists 144 mean follow-up 9.8 years...
To investigate the incidence, age of onset and tumor marker levels in benign malignant pediatric ovarian neoplastic tumors.Retrospective database study.Single-center study.Forty-five 0-15-year-old girls operated on for tumors from beginning 1999 to end 2013.Serum alpha-fetoprotein, human chorionic gonadotropin CA 125 as well follow-up data were recorded patient charts histology was re-evaluated.Incidence population. Differences characteristics between those with tumors.The annual incidence...
Background Peak bone mass, attained by early adulthood, is influenced genetic and life-style factors. Early infant feeding duration of breastfeeding in particular, associate with several health-related parameters childhood. The aim this study was to examine whether the effects extend peak mass other health characteristics at adult age. Methods Findings A cohort 158 adults (76 males) born Helsinki, Finland, 1975, prospectively followed up from birth, underwent physical examination...
Abstract Background Central nervous system (CNS) involvement is associated with relapse in childhood acute lymphoblastic leukemia (ALL) and a diagnostic challenge. Procedure In Nordic/Baltic prospective study, we assessed centralized flow cytometry (FCM) of locally fixed cerebrospinal fluid (CSF) samples versus local conventional cytospin‐based cytology (CC) for detecting leukemic cells evaluating kinetics elimination CSF. Results Among 300 patients newly diagnosed ALL, 87 (29%) had CSF by...