A5012706428- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Adolescent and Pediatric Healthcare
- Family Support in Illness
- Bone health and treatments
- Cancer-related cognitive impairment studies
- Cancer Genomics and Diagnostics
- Vitamin D Research Studies
- Neurological Complications and Syndromes
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Single-cell and spatial transcriptomics
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Autoimmune and Inflammatory Disorders Research
- Cancer Risks and Factors
- Nutrition and Health in Aging
- Management of metastatic bone disease
- Moyamoya disease diagnosis and treatment
- Genomic variations and chromosomal abnormalities
- Immune Cell Function and Interaction
- Brain Metastases and Treatment
Uppsala University
2018-2025
Uppsala University Hospital
2019-2025
Nordic Society for Pediatric Hematology and Oncology
2023
Karolinska Institutet
2014-2021
Karolinska University Hospital
2013-2019
University of Copenhagen
2019
Rigshospitalet
2019
Oulu University Hospital
2002-2017
Queen Astrid Military Hospital
2016
Ludwig Cancer Research
2016
Abstract Background Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential have not comprehensively determined all subtypes ALL on a genome-wide scale. The relationship between methylation, cytogenetic background, drug resistance and relapse is poorly understood. Results We surveyed levels 435,941 CpG sites samples from 764 children at diagnosis 27 relapse. This survey uncovered four characteristic signatures. First,...
Abstract Background In spite of major improvements in the cure rate childhood acute lymphoblastic leukaemia (ALL), 2–4% patients still die from treatment related complications. Procedure We investigated pattern deaths (TRDs) and possible risk factors NOPHO ALL‐92 ALL‐2000 protocols. Fifty‐five TRDs were identified among 1,645 33 1,090 patients. Results There was no significant difference incidence between two protocols (3.4% vs. 3.2%). Five died before initiation therapy (0.2%), overall...
While the prognosis of acute childhood leukemia has improved, long-term survivors are increasingly experiencing late effects treatment. Cranially irradiated predisposed to development CNS tumors. Our aim was describe incidence secondary brain tumors and define significance treatment-related risk factors host characteristics in a cohort survivors. consisted 60 consecutive cranially adult treated Oulu University Hospital (Oulu, Finland); MRI performed on 49. The sites tumors, their histology,...
Purpose The aim of the study was to determine incidence and clinical risk factors for radiographic osteonecrosis (ON) in children treated acute lymphoblastic leukemia (ALL) using Nordic ALL protocols. Patients Methods Ninety-seven consecutive patients with childhood were studied prospectively by magnetic resonance imaging (MRI) lower extremities at end treatment. Results Twenty-three (24%) 97 had ON. Seven (30%) symptomatic, three (13%) required surgical interventions. Multiple logistic...
L-asparaginase is an important drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Treatment associated with several toxicities, including pancreatitis. Clinical course, presentation, re-exposure to L-asparginase after pancreatitis and risk recurrent within asparaginase-intensive protocol has been poorly reported. Children (1–17 years) on ongoing Nordic Society Paediatric Haematology Oncology (NOPHO) ALL2008 asparaginase-associated (AAP) diagnosed between 2008 2012 were...
Background L ‐Asparaginase is an effective drug in the treatment of childhood acute lymphoblastic leukemia (ALL). The use ‐asparaginase may be limited by serious adverse events which allergy most frequent. objective this study was to describe clinical aspects PEG‐asparaginase children treated according Nordic Society Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol. Procedure Children (1–17 years) enrolled NOPHO protocol between July 2008 August 2011, who developed were...
PURPOSE Asparaginase-associated pancreatitis (AAP) is common in patients with acute lymphoblastic leukemia (ALL), but risk differences across age groups both relation to first-time AAP and after asparaginase re-exposure have not been explored. PATIENTS AND METHODS We prospectively registered (n = 168) during treatment of 2,448 consecutive ALL aged 1.0-45.9 years diagnosed from July 2008 October 2018 treated according the Nordic Society Pediatric Hematology Oncology (NOPHO) ALL2008 protocol....
Abstract BACKGROUND Positron emission tomography (PET) scans of primary brain tumors were performed in pediatric patients to examine whether metabolic characteristics could be used as an index clinical aggressiveness. METHODS Twenty‐seven with untreated central nervous system neoplasms studied PET using 2‐[ 18 F] fluoro‐2‐deoxy‐D‐glucose (FDG) and/or L‐[methyl‐ 11 C] methionine (MET). Metabolic assessed FDG and MET standardized uptake values (SUV) SUV‐to‐normal ratios compared histopathology...
Background Interest has recently been paid to adolescents and young adults with acute lymphoblastic leukemia, particularly because all reports so far published indicate that these patients have a better outcome when treated pediatric rather than adult therapeutic protocols. There are different biological subtypes of leukemia distinct features prognoses; the distribution is not well known among adolescents. We, therefore, studied in aged 10 25 years Finland.Design Methods This...
Abstract Background Despite the extensive literature on neuropsychological sequelae after treatment of childhood acute lymphoblastic leukemia (ALL), very‐long‐term neurocognitive outcome survivors is poorly studied. We assessed functioning in a population‐based cohort young adult ALL survivors. Procedure Neuropsychological testing was performed 64 an average 20 years diagnosis. The test battery included verbal intelligence quotient (VIQ) and performance (PIQ), memory function, orientation...
Background Therapy directed at the central nervous system (CNS) is an essential part of treatment for childhood acute lymphoblastic leukemia (ALL). The current evaluation CNS involvement based on cytomorphological examination cerebrospinal fluid (CSF) alone not as sensitive with low cell counts flow cytometric immunophenotyping (FCI) CSF. However, importance CSF blasts diagnosis uncertain. We sought to determine significance FCI in relation conventional morphological examination. Procedure...
Carboxypeptidase G2 (CPDG2 ) can be used as rescue treatment in cases of delayed methotrexate elimination (DME) and Mtx-induced nephrotoxicity.Between July 2008 December 2014, all children (1.0-17.9 years) the Nordic countries diagnosed with Philadelphia chromosome negative acute lymphoblastic leukemia (ALL) were treated according to Organization for Pediatric Hematology Oncology (NOPHO) ALL protocol, including administration six eight high-dose (5 g/m2 /24 hr) Mtx (HDMtx) courses. The...
Abstract Background Posterior reversible encephalopathy syndrome (PRES) is a distinct entity with incompletely known predisposing factors. The aim of this study to describe the incidence, risk factors, clinical course, and outcome PRES in childhood acute lymphoblastic leukemia (ALL). Procedure Patients aged 1.0 17.9 years diagnosed ALL from July 2008 December 2015 treated according Nordic Society Pediatric Hematology Oncology (NOPHO) ALL2008 protocol were included. identified prospective...
Abstract Functional precision medicine (FPM) aims to optimize patient-specific drug selection based on the unique characteristics of their cancer cells. Recent advancements in high throughput ex vivo profiling have accelerated interest FPM. Here, we present a proof-of-concept study for an integrated experimental system that incorporates treatment response with single-cell gene expression output enabling barcoding several conditions one sequencing experiment. We demonstrate this through...
Treatment of childhood acute lymphoblastic leukemia (ALL) may cause structural and functional brain damage. To find out the incidence white matter changes during therapy, a prospective MRI study was designed, findings were correlated with neuropsychological evaluation.Thirty-three children ALL underwent serial cranial before, during, after therapy. Twenty-eight these also assessment at end treatment. They all received intravenous intrathecal methotrexate for central nervous system (CNS) 15...
Purpose Studies concerning the scholastic achievement of survivors childhood leukemia have yielded controversial results. We studied school marks in a register-based study. Patients and Methods Three hundred seventy-one patients with diagnosis before age 16 years who were born between 1974 1986 alive on their 16th birthday identified from Finnish Cancer Registry. Five matched controls sought for each patient Population Register Center Finland. Information ninth-grade report was obtained...
<b>Background: </b> Cancer treatment may affect school performance. Scholastic achievements after childhood brain tumors have not been previously reported on the level of actual grades. <b>Patients and Methods: Patients with tumor (n = 300) were identified from Finnish Registry. Population controls 1,473) matched for age, gender, place living. Their ninth grade reports obtained Statistics Finland. Age at diagnosis cranial irradiation (CRT) considered in analyses, parental education was taken...
Treatment-related osteonecrosis (ON) is a serious complication of treatment acute lymphoblastic leukemia (ALL).This study included 1,489 patients with ALL, aged 1-45 years, treated according to the Nordic Society Paediatric Haematology and Oncology ALL2008 protocol, using alternate-week dexamethasone during delayed intensification, prospective registration symptomatic ON. We aimed at comparing risk factors, timing, clinical characteristics ON in children young adults.ON was diagnosed 67...
Abstract Background Central nervous system (CNS) involvement is associated with relapse in childhood acute lymphoblastic leukemia (ALL) and a diagnostic challenge. Procedure In Nordic/Baltic prospective study, we assessed centralized flow cytometry (FCM) of locally fixed cerebrospinal fluid (CSF) samples versus local conventional cytospin‐based cytology (CC) for detecting leukemic cells evaluating kinetics elimination CSF. Results Among 300 patients newly diagnosed ALL, 87 (29%) had CSF by...
Despite progress in the treatment of childhood acute lymphoblastic leukemia, severe complications are common, and need supportive care is high. We explored cumulative prevalence, clinical risk factors, outcomes children with on first-line leukemia ICUs Sweden.A nationwide prospective register retrospective chart review study.Children were identified, demographic data obtained from Swedish Childhood Cancer Registry. Data intensive collected Intensive Care patients registered ICU admission...
Medulloblastoma is a malignant embryonal tumor of the central nervous system (CNS) that mainly affects infants and children. Prognosis highly variable, molecular biomarkers for measurable residual disease (MRD) detection are lacking. Analysis cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) using broad genomic approaches, such as low-coverage whole-genome sequencing, has shown promising prognostic value. However, more sensitive methods needed MRD analysis. Here, we show technical...