A5014340929- Blood groups and transfusion
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Metallurgical Processes and Thermodynamics
- Chronic Lymphocytic Leukemia Research
- Innovations in Medical Education
- Erythropoietin and Anemia Treatment
- Parvovirus B19 Infection Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Childhood Cancer Survivors' Quality of Life
- Autoimmune Bullous Skin Diseases
- Renal Diseases and Glomerulopathies
- Nuclear reactor physics and engineering
- Iron and Steelmaking Processes
- Complement system in diseases
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Child and Adolescent Health
- Acute Lymphoblastic Leukemia research
Nationwide Children's Hospital
2016-2025
The Ohio State University
2016-2025
Ohio University
2024
Argonne National Laboratory
2019-2023
The Ohio State University Wexner Medical Center
2022
Harvard University
2016
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with isolated and hemorrhagic risk. While many children ITP can be safely observed, treatments are often needed for various reasons, including to decrease bleeding, or improve health related quality of life (HRQoL). There a number available second-line treatments, rituximab, thrombopoietin-receptor agonists, oral immunosuppressive agents, splenectomy, but data comparing treatment outcomes lacking. ICON1 prospective,...
Germline mutations in SAMD9 and SAMD9L genes cause MIRAGE (myelodysplasia, infection, restriction of growth, adrenal hypoplasia, genital phenotypes, enteropathy) (OMIM: *610456) ataxia-pancytopenia *611170) syndromes, respectively, are associated with chromosome 7 deletions, myelodysplastic syndrome (MDS), bone marrow failure. In this retrospective series, we report outcomes allogeneic hematopoietic cell transplantation (HCT) patients hematologic disorders SAMD9/SAMD9L mutations. Twelve...
The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist-oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in America with interest expertise aplastic anemia, inherited failure syndromes, myelodysplastic syndromes. NAPAAC Bone Marrow Failure Diagnosis Care Guidelines Working Group was established the charge harmonizing approach to diagnostic workup anemia an effort standardize best practices field. This...
Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder which presents with isolated and risk of hemorrhage. While most children ITP promptly recover or without drug therapy, persistent chronic in others. When needed, how to select second-line therapies not clear. ICON1, conducted within the Pediatric Consortium North America (ICON), a prospective, observational, longitudinal cohort study 120 from 21 centers starting treatments for examined treatment decisions. Treating...
ABSTRACT While nonpathogenic, the Duffy null phenotype (DN) lowers circulating neutrophils. DN is common among youth with sickle cell disease (SCD), but its implications on absolute neutrophil counts (ANC) and hydroxyurea over time are unclear. Our retrospective review found that all children who were not receiving had stable ANC through age 9 years, those lower mean starting at 6 years of age. Among users, increased time, regardless status, suggesting opportunities to optimize hydroxyurea....
Abstract Congenital Amegakaryocytic Thrombocytopenia (CAMT) is a rare bone marrow failure syndrome that presents with isolated thrombocytopenia within the first year of life. Classic diagnostic findings reveal absent or significantly decreased megakaryocytes otherwise normal cellularity. We present newborn whose initial aspirate showed an appropriate number megakaryocytes. CAMT was subsequently diagnosed after molecular testing demonstrated mutation in thrombopoietin receptor. The presence...
Although recent evidence-based guidelines for the management of immune thrombocytopenia (ITP) recommend a conservative, observation-based approach majority patients with newly diagnosed pediatric ITP, current practice patterns are unknown. This study used Pediatric Health Information System database to examine inpatient care in ITP freestanding US children's hospitals and geographic differences care.Data were extracted from all admissions aged 1 18 years discharged between January 2008...
This study reviewed the standardized records of 1100 patients with symptoms temporomandibular joint syndrome. Of these patients, only 4.5 percent required surgical intervention. The remaining were found to have masticatory muscle spasm and treated by conservative dental methods. Over half had significant macrotrauma jaws in their past history. In addition, electromyographic measurement masseteric silent period duration did not reveal spasm. These factors further serve differentiate patient...
Abstract Consistent with studies showing a high prevalence of the Duffy null phenotype among healthy Black Americans, this retrospective study found that was present in >75% young and contemporary cohort children sickle cell disease (SCD) United States. Despite potential for to impact absolute neutrophil counts, hydroxyurea (HU) dosing, outcomes, it not associated being prescribed lower HU dose or having increased acute SCD visits early treatment course. Future are needed confirm these...
Abstract Through the use of genetic sequencing, molecular variants driving autoimmunity are increasingly identified in patients with chronic and refractory immune cytopenias. With goal discovering that predispose to pediatric thrombocytopenia (ITP) or increase risk for disease, we conducted a genome-wide association study large multi-institutional cohort ITP. A total 591 were genotyped using an Illumina Global Screening Array BeadChip. Six met significance comparison between children ITP...
Key Points HCT prior to onset of neurologic symptoms in children with OSTM1 osteopetrosis does not halt progression.
A 10-year-old female with Williams Syndrome (WS) presented a two-month history of fatigue, weight loss, and bilateral ovarian masses. Histologic, immunophenotypic, cytogenetic studies confirmed the diagnosis Burkitt lymphoma (BL). While there is no established association between two disorders, this third case in literature patient Syndrome.