A5028976385- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Delphi Technique in Research
- COVID-19 and healthcare impacts
- Quantum Mechanics and Applications
- Intensive Care Unit Cognitive Disorders
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Infection Control and Ventilation
- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Inhalation and Respiratory Drug Delivery
- Heart Rate Variability and Autonomic Control
- Frailty in Older Adults
- Quantum and Classical Electrodynamics
- Non-Invasive Vital Sign Monitoring
- Quantum Chromodynamics and Particle Interactions
- Relativity and Gravitational Theory
- Congenital Diaphragmatic Hernia Studies
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Muon and positron interactions and applications
- Malaria Research and Control
MRC Integrative Epidemiology Unit
2021-2025
North Bristol NHS Trust
2016-2025
Liverpool School of Tropical Medicine
2023-2025
MRC Epidemiology Unit
2020-2025
University of Bristol
2015-2024
Respiratory Clinical Trials
2021-2024
Southmead Hospital
2015-2024
Sir Charles Gairdner Hospital
2024
At Bristol
2020-2023
The Recovery Center
2022
The longer-term consequences of SARS-CoV-2 infection are uncertain. Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study (n=163). At 8–12 weeks postadmission, survivors invited a systematic clinical follow-up. Of 131 participants, 110 attended the follow-up clinic. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) limitations in reported physical ability. However, clinically significant abnormalities chest...
### Principles of mechanical ventilation #### Modes Recommendation 1. Pressure-targeted ventilators are the devices choice for acute NIV (Grade B). Good practice points Choice interface 2. A full face mask (FFM) should usually be first type used D). Indications and contra-indications to in AHRF 3. The presence adverse features increase risk failure prompt consideration placement high dependency unit (HDU)/intensive care (ICU) C). Monitoring during Supplemental oxygen therapy with...
<h3>Background</h3> The COPD (chronic obstructive pulmonary disease) assessment test (CAT) is a recently introduced, simple to use patient-completed quality of life instrument that contains eight questions covering the impact symptoms in COPD. It not known how CAT score performs context clinical rehabilitation (PR) programmes or what minimum clinically important difference is. <h3>Methods</h3> introduction as an outcome measure was prospectively studied by PR across London. used alongside...
Background Novel biologic therapies have revolutionised the management of severe asthma with more ambitious treatment aims. Here we analyse definition clinical remission as a suggested goal and consider characteristics associated in large, real-world cohort. Methods This was retrospective analysis patients registered UK Severe Asthma Registry (UKSAR) who met strict national access criteria for biologics. Patients had pre-biologics baseline assessment annual review. The primary applied...
Almost 40 million people currently live with dementia but this is estimated to double over the next 20 years; despite this, research identifying modifiable risk factors scarce. There increasing evidence that cognitive impairment more frequent in those chronic lung disease than without. Chronic obstructive pulmonary affects 210 people, present 60% of certain populations. Co-morbid dysfunction also appears impact on important outcomes such as quality life, hospitalisation and survival. This...
Brain pathology is a poorly understood systemic manifestation of chronic obstructive pulmonary disease (COPD). Imaging techniques using magnetic resonance (MR) diffusion tensor imaging (DTI) and resting state functional MR (rfMRI) provide measures white matter microstructure gray activation, respectively.We hypothesized that patients with COPD would have reduced integrity communication between resting-state networks be significantly different to control subjects. In addition, we tested...
ABSTRACT Background COVID-19 causes a wide spectrum of disease. The incidence and severity sequelae after the acute infection is uncertain. Data measuring longer-term impact on symptoms, radiology pulmonary function are urgently needed to plan follow-up services. Methods Consecutive patients hospitalised with were prospectively recruited this observational study outcomes recorded at 28-days. All invited systematic follow up 8-12 weeks, including chest radiograph, spirometry, exercise test,...
Introduction continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) provide enhanced delivery respiratory support for patients with severe COVID-19. CPAP HFNO are currently designated as aerosol-generating procedures despite limited high-quality experimental data. We aimed to characterise aerosol emission from compare breathing, speaking coughing. Materials methods Healthy volunteers were recruited breathe, speak cough in ultra-clean, laminar flow theatres followed by...
It is now generally accepted that SARS-CoV-2 can be spread by aerosols as well larger droplets from the upper respiratory tract, although relative importance of aerosol transmission remains incompletely answered.1Pöhlker ML Krüger OO Förster J-D et al.Respiratory and in infectious diseases.arXiv. 2021; (published online 1 March.)http://arxiv.org/abs/2103.01188Google Scholar Despite this, current UK infection control guidance for hospitals centred on premise are only generated specific...
BackgroundThe efficacy of daily co-trimoxazole, an antifolate used for malaria chemoprevention in pregnant women living with HIV, is threatened by cross-resistance Plasmodium falciparum to the sulfadoxine–pyrimethamine. We assessed whether addition monthly dihydroartemisinin–piperaquine co-trimoxazole more effective at preventing infection than placebo plus HIV.MethodsWe did individually randomised, two-arm, placebo-controlled trial areas high-grade sulfadoxine–pyrimethamine resistance Kenya...
Background Observational studies suggest an association between reduced lung function and risk of coronary artery disease ischaemic stroke, independent shared cardiovascular factors such as cigarette smoking. We use the latest genetic epidemiological methods to determine whether impaired is causally associated with increased disease. Methods findings Mendelian randomisation uses variants instrumental variables investigate causation. Preliminary analysis used two-sample single nucleotide...
Background: The COPD Assessment Test (CAT) is a recently introduced instrument to assess health-related quality of life in COPD. We aimed evaluate the longitudinal change CAT following Pulmonary Rehabilitation (PR), and test relationship between CRQ-Self Report (SR) over time. hypothesised that would show similar responsiveness PR as CRQ-SR both short medium-term. Methods: 118 patients completed an eight-week outpatient multidisciplinary programme. CAT, incremental shuttle walk (ISW) were...
Healthcare providers need to use clinical judgement, knowledge and expertise when deciding whether it is appropriate apply recommendations for the management of patients.The cited are a guide may not be in all situations.
Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathlessness and wheeze yet frequently misdiagnosed as asthma. Insight regarding the demographic characteristics, abnormalities impact EILO currently limited, with data only available from individual centre reports. The aim this work was to provide broader perspective collaboration between multiple international expert centres.Five geographically distinct clinical paediatric adult centres (3 Denmark, 1 UK, USA)...
Background Gastrointestinal parasite (GIP) infections are a major cause of global morbidity, infecting hundreds millions people each year and potentially leading to lifelong infection serious complications. Few data exist on screening for GIP in migrants entering the UK or current performance different traditional diagnostic approaches. This study aimed describe prevalence Nepalese Gurkha recruits screened arrival UK. Methodology/Principal findings We present retrospective analysis from male...
Background Risk of aerosolisation SARS-CoV-2 directly informs organisation acute healthcare and PPE guidance. Continuous positive airways pressure (CPAP) high-flow nasal oxygen (HFNO) are widely used modes delivery respiratory support for patients with severe COVID-19, both considered as high risk aerosol generating procedures. However, there limited quality experimental data characterising during support. Methods Healthy volunteers were recruited to breathe, speak, cough in ultra-clean,...
Rationale Lung function in early adulthood is associated with subsequent adverse health outcomes. Objectives To ascertain whether stable and reproducible lung trajectories can be derived different populations investigate their association objective measures of cardiovascular structure function. Methods Using latent profile modelling, we studied three population-based birth cohorts repeat spirometry data from childhood into to identify forced expiratory volume 1 s (FEV )/forced vital capacity...