A5004681040- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- Mental Health Research Topics
- Complex Network Analysis Techniques
- Attention Deficit Hyperactivity Disorder
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury Research
- Biomedical and Engineering Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA regulation and disease
- Heart Rate Variability and Autonomic Control
- Transcranial Magnetic Stimulation Studies
- Moyamoya disease diagnosis and treatment
- Health and Medical Research Impacts
- Neural and Behavioral Psychology Studies
- Atomic and Subatomic Physics Research
- Motor Control and Adaptation
- Domain Adaptation and Few-Shot Learning
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
Boston Children's Hospital
2017-2024
Harvard University
2018-2024
Institut des Sciences Cognitives Marc Jeannerod
2021
Harvard University Press
2020
Kennedy Krieger Institute
2020
Boston Children's Museum
2020
Boston University
2014-2017
King's College London
2014-2016
University College London
2013-2016
St George's, University of London
2012-2014
<h3>Objective:</h3> To characterize brain network connectivity impairment in cerebral small-vessel disease (SVD) and its relationship with MRI markers cognitive impairment. <h3>Methods:</h3> A cross-sectional design applied graph-based efficiency analysis to deterministic diffusion tensor tractography data from 115 patients lacunar infarction leukoaraiosis 50 healthy individuals. Structural was estimated between 90 cortical subcortical regions measures of resulting graphs were analyzed....
Brain pathology is a poorly understood systemic manifestation of chronic obstructive pulmonary disease (COPD). Imaging techniques using magnetic resonance (MR) diffusion tensor imaging (DTI) and resting state functional MR (rfMRI) provide measures white matter microstructure gray activation, respectively.We hypothesized that patients with COPD would have reduced integrity communication between resting-state networks be significantly different to control subjects. In addition, we tested...
Cerebral microbleeds (CMBs) are common in cerebral small vessel disease. They may cause cognitive impairment, possibly via white matter tract disruption but previous studies have produced inconsistent results. We determined whether CMB number and location associated with impaired cognition symptomatic disease any association was independent of other magnetic resonance imaging markers disease.One hundred sixteen patients lacunar stroke radiological leukoaraiosis were studied....
Lacunes are an important disease feature of cerebral small vessel (SVD) but their relationship to cognitive impairment is not fully understood. To investigate this we determined (1) the between lacune count and total volume with cognition, (2) spatial distribution lacunes impact location, (3) whole brain anatomical covariance associated these strategically located regions damage. One hundred twenty one patients symptomatic lacunar stroke radiological leukoaraiosis were recruited multimodal...
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. acquisition of multimodal magnetic resonance-based brain data is central to the study's core protocol. However, application Magnetic Resonance Imaging (MRI) methods in this population complicated by technical challenges difficulties imaging life. Overcoming...
Abstract Diffusion models are advantageous for examining brain microstructure non‐invasively and their validation is important transference into the clinical domain. Neurite Orientation Dispersion Density Imaging (NODDI) a promising model estimating multiple diffusion compartments from MRI data acquired in clinically feasible time. As relatively new model, it necessary to examine NODDI under certain experimental conditions, such as change magnetic field‐strength, assess relation tensor...
Background: Nearly 20% of US adolescents report at least one lifetime concussion. Pathophysiologic models suggest that traumatic biomechanical forces caused by rotational deceleration lead to shear stress, which triggers a neurometabolic cascade beginning with excitotoxicity and leading significant energy demands period metabolic crisis for the injured brain. Proton magnetic resonance spectroscopy (1H MRS) offers means non-invasive measurement changes after Objective: Describe longitudinal...
Abstract Preterm infants may exhibit altered developmental patterns of the brain structural network by endogenous and exogenous stimuli, which are quantifiable through hub modular topologies that develop in third trimester. Although preterm networks can compensate for white matter microstructural abnormalities core connections, less is known about how characteristics differ from those full-term infants. We identified 13 hubs 4 modules revealed subtle differences edgewise connectivity local...
Principles of network topology have been widely studied in the human connectome. Of particular interest is modularity brain, where connectome divided into subnetworks from which changes with development, aging or disease can be investigated. We present a weighted measure, Network Dependency Index (NDI), to identify an individual region's importance global functioning network. Importantly, we utilize NDI differentiate four (Tiers) following Gaussian mixture model fitting. analyze topological...
The diffused nature of mild traumatic brain injury (mTBI) impacts white-matter pathways with potentially long-term consequences, even after initial symptoms have resolved. To understand post-mTBI recovery in adolescents, longitudinal studies are needed to determine the interplay between highly individualised trajectories and ongoing development. capture distributed mTBI recovery, we employ connectomes probe brain's structural organisation. We present a diffusion MRI study on adolescent...
Network theory provides a principled abstraction of the human brain: reducing complex system into simpler representation from which to investigate brain organisation. Recent advancement in neuroimaging field are towards representing connectivity as dynamic process order gain deeper understanding interplay between functional modules for efficient information transport. In this work, we employ heat kernels model energy diffusion networks. We extract node-based, multi-scale features describe...
Brainhack is an innovative meeting format that promotes scientific collaboration and education in open inclusive environment. Departing from the formats of typical workshops, these events are based on grassroots projects training, foster reproducible practices. We describe here multifaceted, lasting benefits Brainhacks for individual participants, particularly early career researchers. further highlight unique contributions can make to research community, contributing progress by...