A5083866889- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Diabetes Management and Research
- Anesthesia and Sedative Agents
- Memory and Neural Mechanisms
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Alzheimer's disease research and treatments
- Asthma and respiratory diseases
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- School Health and Nursing Education
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Diabetes Management and Education
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Neurobiology of Language and Bilingualism
- Cardiac Structural Anomalies and Repair
- Psychology of Moral and Emotional Judgment
- Psychedelics and Drug Studies
University of California, San Francisco
2021-2025
University Memory and Aging Center
2021-2025
Ludwig-Maximilians-Universität München
2024
Zimmer Biomet (Germany)
2024
Vertex Pharmaceuticals (United States)
2024
New York Proton Center
2023
University of Virginia Children's Hospital
2022
Virginia Commonwealth University
2022
Institut des Sciences Cognitives Marc Jeannerod
2021
Piedmont Atlanta Hospital
2021
Abstract Focal anterior temporal lobe degeneration often preferentially affects the left or right hemisphere. While patients with left-predominant atrophy show severe anomia and verbal semantic deficits meet criteria for variant primary progressive aphasia dementia, early are more difficult to diagnose as their symptoms less well understood. is associated prominent emotional behavioural changes, meet, go on frontotemporal dementia. Uncertainty around absence of an overarching...
Theory of mind (ToM) is crucial for socioemotional interaction. ToM deficits may explain behavioral changes in dementia, especially Alzheimer's disease (AD) and frontotemporal dementia (FTD). This study examined the psychometrics a new test healthy adults, identified differences syndromes, assessed if scores predict neuropsychiatric function real-life behavior. The UCSF Cognitive Emotional Perspective Taking Test (CEPT) was evaluated 195 adults (age: 42.69 ± 16.20) clinic cohort 304...
Introduction: Cardiac resynchronization therapy (CRT) has been demonstrated to result in clinical improvement older adult patients with dilated cardiomyopathy (DCM), specifically those left bundle branch block and prolonged QRS duration. We sought demonstrate the benefits of CRT on cardiac function outcome young that developed congestive heart failure (CHF) DCM following pacing for AV block. Methods Results: reviewed charts six who CHF or low output symptoms implantation right ventricular...
Within the field of evidence-based practice, a process termed 'evidence mapping' is emerging as less exhaustive yet systematic and replicable methodology that allows an understanding extent distribution evidence in broad clinical area, highlighting both what known where gaps exist. This article describes general principles mapping by using illustrations derived from our experience conducting map interventions for youth mental-health disorders.Evidence maps are based on explicit research...
Stenotrophomonas maltophilia is an opportunistic pathogen observed in both nosocomial and community-onset infections. S. intrinsically resistant to many currently available broad-spectrum antibiotics often not included antimicrobial resistance surveillance studies or stewardship programs' guidelines.A retrospective cohort study of patients with bloodstream infection (BSI) the United States was conducted using 2010-2015 US Premier Healthcare Database. This described patient characteristics,...
Measuring the quality of life caregivers is important for interventions designed young children with asthma. However, little known about impact childhood asthma on parental certain subgroups. This study included families urban mild persistent to severe The goal was evaluate relationship between caregivers' and children's severity, consider influence sociodemographic factors life. Children age 3-7 years (63% male, 59% Black, 75% Medicaid), asthma, were identified from a school-based screening...
<h3>Background</h3> Daily maintenance medications are recommended for all children with mild persistent to severe asthma; however, poor adherence these is common. <h3>Objective</h3> To evaluate the impact of school-based provision inhaled corticosteroids on asthma severity among urban asthma. <h3>Design</h3> Children aged 3 7 years were identified at start 2000-2001 and 2001-2002 school in Rochester. assigned randomly a care group (daily provided through school) or usual-care (inhaled not...
In Brief BACKGROUND: Dexmedetomidine is a highly selective α2-adrenoceptor agonist with sedative, anxiolytic, and analgesic properties that has minimal effects on respiratory drive. Its sedative hypotensive are mediated via central α2A imidazoline type 1 receptors while activation of peripheral α2B-adrenoceptors result in an increase arterial blood pressure systemic vascular resistance. this randomized, prospective, clinical study, we attempted to quantify the short-term hemodynamic...
Introduction. Depression in adolescents and young people is associated with reduced social, occupational, interpersonal functioning, increases suicide self-harm behaviours, problematic substance use. Age-appropriate, evidence-based treatments are required to provide optimal care. Methods. "Evidence mapping" methodology was used quantify the nature distribution of extant high-quality research into prevention treatment depression across psychological, medical, other domains. Results....
Abstract Introduction Individuals with proopiomelanocortin (POMC) or leptin receptor (LEPR) deficiency are young and experience severe obesity, hyperphagia, comorbidities, which can impair quality of life (QOL). Methods Two pivotal Phase 3 trials explored the effect setmelanotide on body weight hunger in individuals obesity due to POMC (NCT02896192) LEPR (NCT03287960) deficiency. QOL depression were investigated parallel using disease-specific, age-appropriate Impact Weight Quality Life-Lite...
To characterize the neurodevelopmental outcomes and identify factors associated with poor in pediatric patients undergoing cardiac extracorporeal membrane oxygenation (ECMO).Five year retrospective review, including demographics, lesion, surgical complexity, reason for ECMO, ECMO complications, status at discharge latest follow-up. Neurodevelopmental was determined through Pediatric Overall Performance Category Cerebral Scales.Overall survival 73% hospital 66% a t Most underwent...
Forty central amygdala neurons labelled with 2% Neurobiotin were categorized according to their distinctive bioelectrical membrane properties and classified physiologically by hyperpolarized resting potential (−74 mV), short duration medium afterhyperpolarization (239.2 ms), non-accommodating response as Type A (63%; N = 25/40), or B (37%; 15/40) depolarized (-66 long slow-afterhyperpolarization (1.8 s), accommodation response. Visualized within subnuclei of the amygdala,...
Examine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass.Prospective, observational.Cardiac operating room ICU.Neonates without history of or anatomic abnormality.None.Renal oximetry was measured intraoperatively for 48 hours postoperatively. Urinary levels neutrophil gelatinase-associated lipocalin inhibitor metalloproteinases 2 together insulin-like...