A5007834870- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Child Abuse and Trauma
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- COVID-19 and Mental Health
- Digital Mental Health Interventions
- Child Welfare and Adoption
- Maternal Mental Health During Pregnancy and Postpartum
- Attachment and Relationship Dynamics
- Impact of Technology on Adolescents
- Early Childhood Education and Development
- Behavioral Health and Interventions
- Hypothalamic control of reproductive hormones
- Child Development and Digital Technology
- Tryptophan and brain disorders
- Family and Disability Support Research
- Diet and metabolism studies
- Gut microbiota and health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Death Anxiety and Social Exclusion
- COVID-19 Pandemic Impacts
- Identity, Memory, and Therapy
Myolex (United States)
2022-2023
University of North Carolina at Chapel Hill
2020-2023
University of Oregon
2015-2022
University of North Carolina Health Care
2022
University of Sussex
2021
University of Washington
2020
Deakin University
2019
Adelphi University
2016
University of California, Los Angeles
2012-2014
Significance Early adversity has profound and lasting effects on neurodevelopment emotional behavior. Under typical environmental conditions, prefrontal cortex connections with the amygdala are immature during childhood become adult-like adolescence. Rodent models show that maternal deprivation accelerates this development as an ontogenetic adaptation to adversity. Here, we demonstrate that, in rodent, children who experienced early exhibit emergence of mature amygdala–prefrontal...
Recent human imaging and animal studies highlight the importance of frontoamygdala circuitry in regulation emotional behavior its disruption anxiety-related disorders. Although tracing have suggested changes amygdala–cortical connectivity through adolescent period rodents, less is known about reciprocal connections within this across development, when these circuits are being fine-tuned substantial control observed. The present study examined developmental amygdala–prefrontal ages 4–22 years...
Mature amygdala-prefrontal circuitry regulates affect in adulthood but shows protracted development. In altricial and semialtricial species, caregivers provide potent regulation when mature neurocircuitry is absent. The present investigation examined a potential mechanism through which regulatory influences childhood. Children, not adolescents, showed evidence of maternal buffering, such that stimuli suppressed amygdala reactivity. the absence stimuli, children exhibited immature...
COVID-19 emerged in November 2019 leading to a global pandemic that has not only resulted widespread medical complications and loss of life, but also impacted economies transformed daily life. The current rapid response study convenience online sample quickly recruited 2,065 participants across the United States, Canada, Europe late March early April 2020. Cross-sectional findings indicated elevated anxiety depressive symptoms compared historical norms, which were positively associated with...
This study aimed to examine changes in depression and anxiety symptoms from before during the first 6 months of COVID-19 pandemic a sample 1,339 adolescents (9-18 years old, 59% female) three countries. We also examined if age, race/ethnicity, disease burden, or strictness government restrictions moderated change symptoms. Data 12 longitudinal studies (10 U.S., 1 Netherlands, Peru) were combined. Linear mixed effect models showed that depression, but not anxiety, increased significantly...
Social media platforms provide adolescents with unprecedented opportunities for social interactions during a critical developmental period when the brain is especially sensitive to feedback.
Early institutional care can be profoundly stressful for the human infant, and, as such, lead to significant alterations in brain development. In animal models, similar variants of early adversity have been shown modify amygdala–hippocampal–prefrontal cortex development and associated aversive learning. The current study examined this rearing aberration Eighty-nine children adolescents who were either previously institutionalized (PI youth; <i>N</i> = 46; 33 females 13 males; age range, 7–16...
Published paper can be found at https://doi.org/10.1111/jora.12781. This study aimed to examine changes in depression and anxiety symptoms from before during the first six months of COVID-19 pandemic a sample 1,339 adolescents three countries (9-18 years old, 59% female). We also examined if age, race/ethnicity, disease burden, or strictness government restrictions moderated change symptoms. Data 12 longitudinal studies (10 U.S., 1 Netherlands, Peru) were combined. Linear mixed effect models...
Although decades of research have shown associations between early caregiving adversity, stress physiology and limbic brain volume (e.g., amygdala, hippocampus), the developmental trajectories these phenotypes are not well characterized. In current study, we used an accelerated longitudinal design to assess development physiology, hippocampal following institutional care. Previously Institutionalized (PI; N = 93) comparison (COMP; 161) youth (ages 4-20 years old) completed 1-3 waves data...
Interpretations of facial expressions with ambiguous valence, such as surprised (which can be perceived having positive or negative valence), reveal individual differences in positivity-negativity biases. Negative interpretations are first and fast, but this initial negativity default overridden by regulatory control processes that result interpretations. We tested the hypothesis examining biases during development. hypothesized childhood, mode would more evident than adulthood and, a group,...
ABSTRACT Traditional conceptualizations of early adversity characterize behavioral outcomes as maladaptive. However, conditional adaptation theory proposes that differing phenotypes following experience are appropriate for the expected environment (e.g., behaviors likely to result in best outcome based on environmental expectations). In present study, youth with ( n = 46) and without 91) a history previous institutionalization completed laboratory‐based experimental paradigm which...
Abstract Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and corticostriatal circuitry, which have demonstrated vulnerability to early exposures adversity, are implicated in many aspects of behavior, including play, aggression, valuation stimuli across development. Here, we used resting-state functional magnetic resonance imaging assess the degree was altered coritocostriatal resting connectivity previously institutionalized youth (...
Abstract Gastrointestinal and mental disorders are highly comorbid, animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain bacteria live within gastrointestinal system (the microbiome) underlie adversity–gastrointestinal–anxiety interactions, but these links not been investigated during human development. In this study, we utilized data from a population of 344 youth (3–18 years old) who were raised with their...
Although the functional architecture of brain is indexed by resting-state connectivity networks, little currently known about mechanisms through which these networks assemble into stable mature patterns. The current study posits and tests long-term phasic molding hypothesis that are gradually shaped recurring stimulus-elicited across development examining how both connections human emerge over at systems level. Using a sequential design following 4- to 18-year-olds 2 year period, we examined...
Psychosocial environments impact normative behavioral development in children, increasing the risk of problem behaviors and psychiatric disorders across life span. Converging evidence demonstrates that early is affected by gut microbiome, which itself can be altered psychosocial environments. However, much our understanding microbiome's role stems from nonhuman animal models predominately focuses on first years life, during peri- postnatal microbial colonization. As a step to identify if...
COVID-19 emerged in November 2019 leading to a global pandemic that has not only resulted widespread medical complications and loss of life, but also impacted economies transformed daily life. The current rapid response study convenience online sample quickly recruited 2,065 participants across the United States, Canada, Europe late March early April 2020. Cross-sectional findings indicated elevated anxiety depressive symptoms compared historical norms, which were associated with concern...
Abstract Institutional caregiving is associated with significant deviations from species-expected caregiving, altering the normative sequence of attachment formation and placing children at risk for long-term emotional difficulties. However, little known about factors that can promote resilience following early institutional caregiving. In current study, we investigated how adaptations in affective processing (i.e., positive valence bias) family-level protective secure parent–child...