A5022834577- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Gut microbiota and health
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Memory and Neural Mechanisms
- Child Abuse and Trauma
- Attachment and Relationship Dynamics
- COVID-19 and Mental Health
- Adolescent and Pediatric Healthcare
- Infant Development and Preterm Care
- Family Support in Illness
- Early Childhood Education and Development
- Regulation of Appetite and Obesity
- Neurotransmitter Receptor Influence on Behavior
- Health disparities and outcomes
- Psychosomatic Disorders and Their Treatments
- Infant Health and Development
- Resilience and Mental Health
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Food Security and Health in Diverse Populations
- Gastrointestinal motility and disorders
- Nicotinic Acetylcholine Receptors Study
University of California, Los Angeles
2020-2025
UCLA Health
2020-2023
Columbia University
2014-2022
Great Ormond Street Hospital for Children NHS Foundation Trust
2022
The University of Melbourne
2013-2021
Melbourne Health
2017-2021
Great Ormond Street Hospital
2015-2020
University College London
2015-2020
Belfast Health and Social Care Trust
2018
New York Psychoanalytic Society and Institute
2017
Recent studies in rats have shown that extinction occurring early life is resistant to relapse and may represent the erasure of fear memories. In present study we examined effects stress on developing rat, which could important implications for treatment anxiety disorders those who experienced stress. study, used maternal-separation postnatal days (P) 2-14 as an stressor. On P17, maternally separated standard-reared animals were trained a noise associated with footshock. The this was then...
development and implementation of effective family-based psychosocial intervention treatment strategies during COVID-19 will require a detailed understanding how the virus has impacted lives families.written reports on life impacts for parents (n = 56) their children 43), questionnaire assessing parent positive negative affect, were collected between April May 2020. An inductive approach was used to identify themes in written reports, followed by statistical analysis explore associations...
Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights gut microbiome as a putative biological mechanism underlying such generational risks. In sample of 450 mother–child dyads living Singapore, we examined associations between three distinct adversity experienced two generations—maternal childhood maltreatment, maternal anxiety, second-generation...
The long-lasting influence of childhood adversity on mental health is well documented; however empirical research examining how this association extends into older adults limited. This study defines using cumulative risk and latent class analysis (LCA) models to assess exposure typologies may predict anxiety depression in adults. Data came from the Personality Total Health (PATH) Through Life Project (N = 2551, age 60–66). Participants retrospectively reported their experiences domestic a...
Mental health problems are often assumed to have their roots in early-life experiences. However, memories acquired infancy rapidly forgotten nearly all species (including humans). As yet, a testable mechanism on how experiences lasting impact mental is lacking. In these experiments, we tested the idea that infant adversity leads an early transition into adult-like fear retention, allowing longer-lasting influence. Rats were exposed maternal separation (3 h per day) across postnatal days (P)...
Abstract Recently, scientific interest in the brain–gut axis has grown dramatically, particularly with respect to link between gastrointestinal and psychiatric dysfunction. However, role of gut function early emotional dysregulation is yet be examined, despite prevalence treatment resistance early-onset disorders. The present studies utilized a developmental rodent model early-life stress (ELS) explore this gap. Rats were exposed maternal separation (MS) on postnatal days 2–14. Throughout...
Abstract Gastrointestinal and mental disorders are highly comorbid, animal models have shown that both can be caused by early adversity (e.g., parental deprivation). Interactions between the brain bacteria live within gastrointestinal system (the microbiome) underlie adversity–gastrointestinal–anxiety interactions, but these links not been investigated during human development. In this study, we utilized data from a population of 344 youth (3–18 years old) who were raised with their...
This Viewpoint discusses the concept of “mommy brain” and why it needs to change.
α-Conotoxins that are thought to act as antagonists of nicotinic acetylcholine receptors (nAChRs) containing α3-subunits efficacious in several preclinical models chronic pain. Potent interactions Vc1.1 with other targets have suggested the pain-relieving actions α-conotoxins might be mediated by either α9α10 nAChRs or a novel GABAB receptor-mediated inhibition N-type calcium channels. Here we establish three α-conotoxins, Vc1.1, AuIB and MII distinct selectivity profiles for these potential...
Early-life adversity is a potent risk factor for mental-health disorders in exposed individuals, and effects of are exhibited across generations. Such adversities also associated with poor gastrointestinal outcomes. In addition, emerging evidence suggests that microbiota-gut-brain interactions may mediate the early-life stress on psychological dysfunction. present study, we administered an stressor (i.e., maternal separation) to infant male rats, investigated this conditioned aversive...
Many social activities moved online during the global COVID-19 pandemic, yet research investigating whether virtual interactions facilitate connectedness has been inconclusive. In this study, participants completed questionnaires assessing objective isolation, loneliness, mental health, and interactions. There was clear evidence for worsening health among emerging adults pandemic characterized by large increases in depressive symptoms (mean increase = 8.35, 95% CI [6.97, 9.73],
Recent studies have shown that chronic early life stress results in precocious expression of the adult-like phenotype fear retention and inhibition. However, it is unknown whether experience acute trauma has same effects as exposure to stress. In present study, a 24-hr period maternal deprivation on postnatal day (P) 9 was used an stressor. infancy (P16-17), maternally deprived standard-reared rats were conditioned noise paired with shock. Experiments 1 2, then extinguished before tested for...