A5055854484- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Infant Development and Preterm Care
- Sleep and related disorders
- Early Childhood Education and Development
- Birth, Development, and Health
- Sleep and Wakefulness Research
- Child Nutrition and Feeding Issues
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Maternal and Perinatal Health Interventions
- Autism Spectrum Disorder Research
- Child Development and Digital Technology
- Child Abuse and Trauma
- Language Development and Disorders
- Bipolar Disorder and Treatment
- Dialysis and Renal Disease Management
- Obesity, Physical Activity, Diet
- Pregnancy and Medication Impact
- Circadian rhythm and melatonin
- Grief, Bereavement, and Mental Health
- Breastfeeding Practices and Influences
- Assisted Reproductive Technology and Twin Pregnancy
- Homicide, Infanticide, and Child Abuse
- Family and Disability Support Research
Vrije Universiteit Amsterdam
2019-2025
OLVG
2020-2025
Amsterdam University Medical Centers
2020-2025
Public Health Service of Amsterdam
2023-2025
Public Health Institute
2024-2025
Singapore Institute for Clinical Sciences
2015-2024
Agency for Science, Technology and Research
2015-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017-2023
GGZ inGeest
2022
University Medical Center
2021
Prenatal maternal depression is associated with alterations in the neonatal amygdala microstructure, shedding light on timing for influence of prenatal brain structure offspring. This study aimed to examine association between depressive symptomatology and infant functional connectivity thus establish neural basis transgenerational transmission vulnerability affective disorders during development. Twenty-four infants were included this both structural magnetic resonance imaging (MRI)...
Abstract Mechanisms underlying the profound parental effects on cognitive, emotional and social development in humans remain poorly understood. Studies with nonhuman models suggest variations care affect limbic system, influential to learning, autobiography regulation. In some research, nonoptimal relates decreases neurogenesis, although other work suggests early-postnatal adversity accelerates maturation of structures associated learning. We explored whether maternal sensitivity predicts...
To explore the associations between type of milk feeding (the "nutrients") and mode breast "nursing") with child cognition. Healthy children from GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort participated repeated neurodevelopmental assessments 6 54 months. For "nutrients", we compared exclusively bottle-fed according to received: formula only (n = 296) vs some/all 73). "nursing", included who were fully fed milk, comparing those directly at 59) partially/completely by...
<h3>Importance</h3> Active participation in care by parents and zero separation between their newborns is highly recommended during infant hospitalization the neonatal intensive unit (NICU). <h3>Objective</h3> To study association of a family integrated (FICare) model with maternal mental health at hospital discharge preterm newborn compared standard (SNC). <h3>Design, Setting, Participants</h3> This prospective, multicenter cohort included mothers infants born treated level-2 units...
Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights gut microbiome as a putative biological mechanism underlying such generational risks. In sample of 450 mother–child dyads living Singapore, we examined associations between three distinct adversity experienced two generations—maternal childhood maltreatment, maternal anxiety, second-generation...
Objective: Exposure to antenatal maternal anxiety and complex genetic variations may shape fetal brain development. In particular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates catecholamine signaling in prefrontal cortex is implicated anxiety, pain, stress responsivity. This study examined whether individual single-nucleotide polymorphisms (SNPs) of COMT gene their haplotypes moderate association between utero cortical Method: A total 146 neonates...
Appetitive traits in childhood such as food responsiveness and enjoyment of have been associated with body mass index (BMI) later childhood. However, data on appetitive during infancy relation to BMI are sparse. We aimed relate subsequent weight gain up 24 months age. Data 210 infants from the Singapore GUSTO mother-offspring cohort was obtained. The Baby Eating Behavior Questionnaire (BEBQ) Child (CEBQ) were administered mothers when their offspring aged 3 12 respectively. Height measured...
Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout central nervous system, on degree antenatal maternal anxiety associated neonatal DNA methylation. We also association between methylation and brain substructure volume, as function BDNF genotype. Infant, but not maternal, dramatically influences epigenome...
This study investigated the relationships between pre- and early post-natal maternal depression their changes with frontal electroencephalogram (EEG) activity functional connectivity in 6- 18-month olds, as well externalizing internalizing behaviors 24-month olds (n = 258). Neither prenatal nor postnatal depressive symptoms independently predicted neither EEG infants. However, increasing from to period greater right relative asymmetry amongst 6-month infants but these finding were not...
Objective The coronavirus disease (COVID-19) pandemic has negatively affected many people's mental health with increased symptoms of stress, anxiety and depression in the general population. Anxiety can have negative effects on pregnant women result poor neonatal outcomes. Therefore, we analyzed during COVID-19 pandemic.
Birth parameters have been hypothesized to an influence on IQ. However, studies within the range of normal birth size sparse. With this study we examined associations between length, weight, head circumference, and gestational age in relation childhood IQ Asian children.A cohort 1979 2913 children aged 7 9 years, recruited from 3 schools Singapore, were followed yearly 1999 onward. recorded by health personnel. Childhood was measured with Raven's Standard Progressive Matrices at ages 8...
Abstract While many studies focus on the association between early life adversity and later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those that examined cumulative impact uniquely postnatal influences. The objective this study was to fetal period development construct validate a prenatal score in relation wide range neurodevelopmental outcomes. We also interaction with biologically informed genetic based serotonin transporter...
Abstract The quality of prenatal maternal mental health, from psychological stress and depressive symptoms to anxiety other nonpsychotic disorders, profoundly affects fetal neurodevelopment. Despite the evidence for influence positive well-being on there is, our knowledge, no research examining possible effects antenatal health development offspring. Using exploratory bifactor analysis, this prospective study ( n = 1,066) demonstrated feasibility using common psychiatric screening tools...
Objective Analyze the relation of gestational diabetes and maternal blood glucose levels to early cognitive functions in first two years life. Methods In a prospective Singaporean birth cohort study, pregnant women were screened for at 26–28 weeks gestation using 75-g oral tolerance test. Four hundred seventy three children (n = 74 n 399 born mothers with without respectively) underwent neurocognitive assessments 6, 18, and/or 24 month, including electrophysiology during an attentional task...
The relative impact of parenting on socio-emotional development children has rarely been examined in a longitudinal context. This study the association between perceived styles and functioning from childhood to adolescence. We hypothesized that optimal associated with improvement into early adulthood, especially for those more behavioral problems childhood. Children ages 7 9 years were recruited Singapore Cohort Study Risk Factors Myopia (SCORM). Nine later, 700 out 1052 subjects followed up...
<h3>Importance</h3> During newborn hospitalization in the neonatal unit, fathers often feel anxious and excluded from their child's caregiving decision-making. Few studies interventions have focused on fathers' mental health participation care. <h3>Objective</h3> To study association of a family integrated care (FICare) model (in single rooms with complete couplet-care for mother-newborn dyad) vs standard (SNC) open bay units separate maternity outcomes at hospital discharge preterm to...
There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed the general population and likely to share common etiology ASD. A number measures have been developed assess quantitatively unselected samples. So far, Quantitative-Checklist for Autism Toddlers (Q-CHAT) one very few use toddlers as young 18 months, but little known about its measurement properties factor structure.The...
This study investigated whether child exuberance, an aspect of temperament related to emotion regulation, moderates the well‐documented association between high parenting stress and increased risk for internalizing externalizing problems during preschool years. At 42 months age exuberance was observed in 256 children (47% girls) maternal self‐reports on were obtained. 48 assessed through reports from both parents. Indeed, higher problems, this more pronounced among with levels exuberance....
Abstract This study aimed to examine heterogeneity of neonatal brain network and its prediction child behaviors at 24 48 months age. Diffusion tensor imaging (DTI) tractography was employed construct anatomical for 120 neonates. Clustering coefficients individual structures were computed used classify neonates with similar networks into one group. Internalizing externalizing behavioral problems assessed using maternal reports the Child Behavior Checklist (CBCL) The profile CBCL internalizing...
Evidence on long-term influences of maternal vitamin B12 deficiency or concentrations infant cognition is limited. We examined associations between plasma and cognitive development in 24-month-old infants. Maternal were measured at 26-28 weeks' gestation; was assessed with the Bayley Scales Infant Toddler Development-III 24 months, for 443 mother-infant pairs from Growing Up Singapore Towards Healthy Outcomes cohort. Linear regressions adjusted key confounders cognitive, receptive expressive...
Evidence on the association between sleep, diet, and eating behaviors in pregnant women is lacking. We examine this a cohort of apparently healthy women. At 26–28 weeks gestation, 497 participants completed Pittsburgh Sleep Quality Index to assess sleep 24-h recall dietary intake. Diet quality was assessed by Healthy Eating for Singapore (HEI-SGP) score previously derived patterns (vegetables-fruit-rice, seafood-noodles, pasta-cheese-meat pattern). studied included longest night-time fasting...