A5046691960- Asthma and respiratory diseases
- Birth, Development, and Health
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Dermatology and Skin Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and preeclampsia studies
- Child Nutrition and Feeding Issues
- Breastfeeding Practices and Influences
- Gut microbiota and health
- Infant Health and Development
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Nutritional Studies and Diet
- Child and Adolescent Psychosocial and Emotional Development
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Eosinophilic Esophagitis
- Sleep and related disorders
- Respiratory and Cough-Related Research
- Eating Disorders and Behaviors
- Child Development and Digital Technology
SingHealth
2023-2025
National University of Singapore
2016-2025
Duke-NUS Medical School
2023-2025
KK Women's and Children's Hospital
2018-2025
SingHealth Duke-NUS Academic Medical Centre
2023-2025
Agency for Science, Technology and Research
2015-2024
Singapore Institute for Clinical Sciences
2015-2024
National University Health System
2015-2024
National University Hospital
2015-2024
Khoo Teck Puat Hospital
2014-2022
ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations. These concur with regard to clinical features that indicate likely diagnosis of -- life-threatening generalized or systemic allergic hypersensitivity reaction.They also about prompt initial treatment intramuscular injection epinephrine (adrenaline) in mid-outer thigh, positioning patient...
Saw Swee Hock School of Public Health, National University Singapore, Department Paediatrics, Yong Loo Lin Medicine, Obstetrics & Gynaecology, Health System, Singapore Institute for Clinical Sciences, Agency Science and Technology Research (A*STAR), Brenner Centre Molecular Liggins Institute, Auckland, New Zealand, Medical Council Lifecourse Epidemiology Unit, Southampton, UK, NIHR Southampton Biomedical Centre, Hospital NHS Foundation Trust, Biostatistics KK Women’s Children’s Hospital,
Abstract Maternal depressive symptoms influence neurodevelopment in the offspring. Such effects may appear to be gender-dependent. The present study examined contributions of prenatal and postnatal maternal volume microstructure amygdala 4.5-year-old boys girls. Prenatal were measured using Edinburgh Postnatal Depression Scale (EPDS) at 26 weeks gestation. depression was assessed 3 months EPDS 1, 2, 4.5 years Beck’s Inventory-II. Structural magnetic resonance imaging diffusion tensor...
Abstract The paucity of information on longevity vaccine-induced immune responses and uncertainty the correlates protection hinder development evidence-based COVID-19 vaccination policies for new birth cohorts. Here, to address these knowledge gaps, we conducted a cohort study healthy 5–12-year-olds vaccinated with BNT162b2. We serially measured binding neutralizing antibody titers (nAbs), spike-specific memory B cell (MBC) spike-reactive T over 1 year. found that children mounted antibody,...
Cow milk allergy (CMA) is one of the most common food allergies in childhood. Patients with CMA present a wide range immunoglobulin (Ig)E- and non-IgE-mediated clinical syndromes. Limited information known about specific humoral cellular responses to cow proteins these various forms CMA.The aim study was determine IgE, IgA, IgG1 IgG4 antibody levels lymphocyte proliferative major allergens patients IgE- CMA.One hundred forty allergic patients, 6 months 22 years age, were included study. One...
The role of probiotics in allergy prevention remains uncertain but has been shown some studies to have a possible protective effect on eczema.We aimed assess the probiotic supplementation first 6 months life eczema and allergic sensitization at 1 year age Asian infants risk disease.A double-blind, placebo-controlled randomized clinical trial involving 253 with family history disease was carried out. Infants received least 60 mL commercially available cow's milk formula or without...
Abstract Faster eating rates are associated with increased energy intake, but little is known about the relationship between children’s rate, food intake and adiposity. We examined whether children who eat faster consume more this higher weight status hypothesised that rate mediates child ad libitum intake. Children ( n 386) from Growing Up in Singapore Towards Healthy Outcomes cohort participated a video-recorded lunch at 4·5 years to measure acute Videos were coded for three...
To explore the associations between type of milk feeding (the "nutrients") and mode breast "nursing") with child cognition. Healthy children from GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort participated repeated neurodevelopmental assessments 6 54 months. For "nutrients", we compared exclusively bottle-fed according to received: formula only (n = 296) vs some/all 73). "nursing", included who were fully fed milk, comparing those directly at 59) partially/completely by...
Evidence is accumulating that the establishment of gut microbiome in early life influences development atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which modulates eczema risk. We measured functionality and metabolome 63 infants between ages 3 weeks 12 months with well-defined cases controls a sub-cohort from Growing Up Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. At weeks, allergen-sensitized were...
Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and IL-12 IL-23 mycobacterial diseases). Cells common P1104A allele selectively impaired isolated disease). We report three new forms of deficiency six patients from five families (R864C, G996R, G634E, or G1010D) compound heterozygous a (A928V). All these missense encode detectable proteins. The R864C G1010D are...
Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between oxylipins and on the superficial of pre-pubescent children (N = 36) adults 100), including pre- 25) post-menopausal females 25). Lipidomics metagenomics revealed that Malassezia restricta positively correlated with oxylipin 9,10-DiHOME adult negatively its precursor, 9,10-EpOME, skin. Co-culturing keratinocytes demonstrated a link...
Eczema is a chronic form of childhood disorder that gaining in prevalence affluent societies. Previous studies hypothesized the development eczema correlated with changes microbial profile and composition early life endemic microbiota, but contradictory conclusions were obtained, possibly due to lack minimization apparent non-health related confounders (e.g., age, antibiotic consumption, diet mode delivery). In this study, we recruited seven caesarean-delivered total formula-fed infants,...
This was a multicenter, blinded, Phase II study (NCT00880893) conducted in Singapore. The primary objectives were to evaluate the safety of tetravalent dengue vaccine (TDV) comprising four recombinant, live, attenuated viruses (CYD-TDV) and virus serotype-specific antibody responses before 28 d after each vaccination. Participants randomized 3:1 receive three doses CYD-TDV or control at 0, 6 12 mo. Control placebo for first dose (all ages) subsequent doses, licensed hepatitis-A children...
Higher screen viewing time (SVT) in childhood has been associated with adverse health outcomes, but the predictors of SVT early are poorly understood. We examined sociodemographic and behavioral total device-specific a Singaporean cohort. At ages 2 3 years, 910 children was reported by their parents. Interviewer-administered questionnaires assessed on weekdays weekends for television, computer, hand-held devices. Multivariable linear mixed-effect models were used to examine associations at...
Perinatal maternal depressive symptoms influence brain development of offspring. Such effects are particularly notable in the amygdala, a key structure involved emotional processes. This study investigated whether functional organization amygdala varies as function pre- and postnatal symptoms. The network was assessed using resting-state magnetic resonance imaging (rs-fMRI) 128 children at age 4.4 to 4.8 years. Maternal were obtained 26 weeks gestation, 3 months, 1, 2, 3, 4.5 years after...
Background. A safe, effective tetravalent dengue vaccine is a global health priority. The safety and immunogenicity of live attenuated, recombinant candidate (TDV) were evaluated in healthy volunteers from dengue-endemic countries.