A5102859115- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Neurological Disorders and Treatments
- Sleep and related disorders
- Bioinformatics and Genomic Networks
- Trauma and Emergency Care Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Folate and B Vitamins Research
- Cerebrovascular and genetic disorders
- Spatial Neglect and Hemispheric Dysfunction
- S100 Proteins and Annexins
- Blood Pressure and Hypertension Studies
- Sleep and Wakefulness Research
- Herpesvirus Infections and Treatments
- Cognitive Abilities and Testing
University of California, San Francisco
2015-2025
University Memory and Aging Center
2015-2025
Alzheimer’s Disease Neuroimaging Initiative
2024
San Francisco VA Medical Center
2015-2022
Global Brain Health Institute
2020-2022
University of California San Francisco Medical Center
1991-2021
University of Washington
2021
Trinity College Dublin
2020
Universidade Federal de Minas Gerais
2020
University of California, Berkeley
2013-2020
To assess the ability of a brief neuropsychological bedside screening battery to discriminate between Alzheimer disease, frontotemporal dementia, and semantic dementia.Subjects were 21 patients with 14 30 disease comparable in terms Mini Mental Status Examination score, age, education. Frontotemporal dementia diagnoses made clinically using consensus criteria Neary et al. 1 Subjects administered assessing episodic memory, working executive function, naming, spatial ability, abstract...
Background: Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but sites of earliest injury remain unclear.Objective: To determine atrophy patterns in distinct clinical stages bvFTD, testing hypothesis that mildest stage is restricted to paralimbic cortex.Design: A bvFTD cohort study.Setting: University hospital clinic.Participants: Patients with Clinical Dementia Rating (CDR) scale scores 0.5 (n=15), 1 or 2 3 (n=15) age and sex matched each other 45...
We examined whether the effect of apolipoprotein E (<i>APOE</i>) genotype on functional brain connectivity is modulated by gender in healthy older human adults. Our results confirm significantly decreased default mode network <i>APOE</i> ε4 carriers compared with ε3 homozygotes. More important, further testing revealed a significant interaction between and precuneus, major hub. Female showed reduced either female homozygotes or male carriers, whereas differed minimally from An additional...
Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of CSF NfL levels FTD.CSF NfL, amyloid-β1-42 (Aβ42), tau, and phosphorylated tau concentrations were compared 47 normal controls (NC), 8 asymptomatic gene carriers (NC2) FTD-causing mutations, 79 FTD (45 behavioral variant dementia [bvFTD], 18 progressive nonfluent aphasia [PNFA], 16 semantic [SD]),...
Abstract Co-pathologies play an important role in the expression of Alzheimer’s disease clinical phenotype and may influence treatment efficacy. Early-onset disease, defined as manifesting before age 65, is viewed a relatively pure form with more homogeneous neuropathological substrate. We sought to compare frequency common diagnoses consecutive autopsy series 96 patients early-onset (median onset = 55 years, 44 females) 48 late-onset 73 14 females). The UCSF Neurodegenerative Disease Brain...
Abstract Focal anterior temporal lobe degeneration often preferentially affects the left or right hemisphere. While patients with left-predominant atrophy show severe anomia and verbal semantic deficits meet criteria for variant primary progressive aphasia dementia, early are more difficult to diagnose as their symptoms less well understood. is associated prominent emotional behavioural changes, meet, go on frontotemporal dementia. Uncertainty around absence of an overarching...
Objectives To investigate the objective sleep influencers behind older adult responses to subjective measures, in this case, Pittsburgh Sleep Quality Index (PSQI). Based on previous literature, we hypothesized that SE would be associated with PSQI reported disruption. Furthermore, because SOL increases progressively age and it tends easily remembered by patients, also expected one of main predictors perceived quality elderly. Methods We studied 32 cognitively healthy community-dwelling...
To test if arterial spin labeling (ASL) MRI could detect a pattern of hypoperfusion in frontotemporal dementia (FTD) vs cognitively normal (CN) control subjects; to determine the regional difference perfusion between FTD and Alzheimer disease (AD); whether correlates with cognitive impairment.We included 21 patients FTD, 24 AD, 25 CN subjects this cross-sectional study. All had scans including T1-weighted structural images ASL-MR images.ASL-MRI detected right frontal regions subjects,...
Erythrocytes are transfused to prevent or treat inadequate oxygen delivery resulting from insufficient hemoglobin concentration. Previous studies failed find evidence of systemic at a concentration 5 g/dl. However, in those studies, sensitive, specific measures critical organ function were not used. This study tested the hypothesis that acute severe decreases alters human cognitive function.Nine healthy volunteers, age 29 +/- yr (mean SD), with verbal memory and standard, computerized...
We compared the predictive value of cerebral perfusion as measured by arterial-spin labeling magnetic resonance imaging (ASL-MRI) with MRI-derived hippocampal volume for determining future cognitive and functional decline subsequent conversion from mild impairment to dementia. Forty-eight subjects received structural ASL-MRI scans at baseline clinical neuropsychologic assessments annually. Thirteen became demented during period longitudinal observation (2.7±1.0 y). Cox regression analyses...
<b><i>Objective:</i></b> To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI). <b><i>Background:</i></b> Previous cross-sectional studies examining the relationship between impairment dementia have shown that hippocampal cortical gray matter atrophy are most important predictors impairment, even cases with SCVBI. The authors hypothesized volume also would best predict rate without <b><i>Methods:...
Although sex differences in verbal learning and memory have been reported adults, much less is known about when these emerge how they develop. In this study, 401 boys 410 girls between the ages of 5 16 years were administered California Verbal Learning Test--Children's Version. Sex found at all age levels. Girls performed better than on immediate delayed recall trials recognition trial. also more likely to use a semantic clustering strategy displayed effective long-term mechanisms. Boys made...
Erythrocytes are transfused to treat or prevent imminent inadequate tissue oxygenation. 2,3-diphosphoglycerate concentration decreases and oxygen affinity of hemoglobin increases (P50 decreases) with blood storage, leading some propose that erythrocytes stored for 14 more days do not release sufficient make their transfusion efficacious. The authors tested the hypothesis 3 weeks as effective in supplying human tissues less than 5 h.Nine healthy volunteers donated 2 units before they were a...
<h3>Background</h3> The aetiology and pathogenesis of non-genetic forms frontotemporal dementia (FTD) is unknown even with the genetic FTD, remains elusive. Given association between systemic inflammation other neurodegenerative processes, links autoimmunity FTD need to be explored. <h3>Objective</h3> To describe prevalence autoimmune disease in semantic variant primary progressive aphasia (svPPA), a clinical cohort, progranulin (PGRN) mutation carriers compared neurologically healthy normal...
Sleep disturbance is common among patients with neurodegenerative diseases. Examining the subcortical neuronal correlates of sleep disturbances important to understanding early-stage phenomena.
Diffusion tensor imaging (DTI) literature on single-center studies contains conflicting results regarding acute effects of mild traumatic brain injury (mTBI) white matter (WM) microstructure and the prognostic significance. This larger-scale multi-center DTI study aimed to determine how mTBI affects WM over time early changes affect long-term outcome. From Transforming Research Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI), a cohort at 11 United States level 1 trauma centers,...
Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss Alzheimer's disease (AD) and related tauopathies. Here, we found reduced levels of memory-associated protein KIdney/BRAin (KIBRA) brain increased KIBRA cerebrospinal fluid are associated with cognitive impairment pathological disease. We next defined for repair vulnerable neurons using C-terminus (CT-KIBRA). showed CT-KIBRA restored transgenic mice expressing human tau;...
Vitamin B12 (B12) plays a critical role in fatty- and amino-acid metabolism nucleotide synthesis. While the association between deficiency neurological dysfunction is well-known, exact threshold for adequacy remains undefined terms of functional impairment evidence injury. The objective was to assess whether levels within current normal range cohort healthy older adults may be associated with measurable injury or dysfunction. We enrolled 231 elderly volunteers (median age 71.2 years old)...
Frontotemporal dementia (FTD) is associated with a variety of cognitive and behavioral dysfunctions. Symptoms may be influenced by the relative involvement right versus left hemisphere, left-sided FTD manifesting language changes right-sided presenting aggressive, antisocial, other socially undesirable behaviors.To test hypothesis that behavior.The authors assessed 41 patients diagnosed new research criteria for FTD(1) including behavioral, neuropsychologic, neurologic testing as well SPECT...
The salience network is a distributed neural system that maintains homeostasis by regulating autonomic nervous activity and social-emotional function. Here we examined how within-network connectivity relates to individual differences in human (including males females) baseline parasympathetic sympathetic activity. We measured resting physiology 24 healthy controls 23 patients with behavioral variant frontotemporal dementia (bvFTD), neurodegenerative disease characterized deficits....
To evaluate the effect of amyloid imaging on clinical decision making.We conducted a retrospective analysis 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.3) who underwent (Pittsburgh compound B [PiB]) PET as part observational research studies and were evaluated clinically before after scan. One hundred thirty-four concurrently fluorodeoxyglucose (FDG)-PET. We assessed for changes between pre- post-PET...
Mental health problems, such as depression and anxiety, are often associated with functional limitations after traumatic brain injury (TBI), prompting researchers to explore which of these TBI-related sequelae tends precede the other. Past studies among patients injuries ranging in severity have predominantly reported that impairments predict subsequent psychological concerns, rather than other way around; however, it remains unclear whether this directionality holds for individuals mild TBI...
Abstract INTRODUCTION Sleep–wake disturbances are a prominent feature of Alzheimer's disease (AD). Atypical (non‐amnestic) AD syndromes have different patterns cortical vulnerability to AD. We hypothesized that atypical also shows differential in subcortical nuclei will manifest as sleep dysfunction. METHODS Overnight electroencephalography monitoring was performed on 48 subjects, including 15 amnestic, 19 AD, and 14 controls. defined based neuropathological or biomarker confirmation....