Adam R. Ferguson
A5019326045- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Spinal Cord Injury Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Pain Mechanisms and Treatments
- Nerve Injury and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Nerve injury and regeneration
- Spinal Dysraphism and Malformations
- Neuroinflammation and Neurodegeneration Mechanisms
- Sepsis Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Spinal Fractures and Fixation Techniques
- Ethics in Clinical Research
- Cell Image Analysis Techniques
- Meta-analysis and systematic reviews
- Neurogenesis and neuroplasticity mechanisms
- Artificial Intelligence in Healthcare and Education
- Trauma Management and Diagnosis
- Advanced Neuroimaging Techniques and Applications
- Aortic Disease and Treatment Approaches
University of California, San Francisco
2016-2025
Neurological Surgery
2016-2025
San Francisco General Hospital
2016-2025
San Francisco VA Medical Center
2016-2025
The Ohio State University
2004-2024
San Francisco VA Health Care System
2019-2024
Universidad Católica de Santa Fe
2024
University of Pennsylvania
2018-2023
Center for Neurosciences
2020-2023
King's College London
2023
To determine the clinical relevance, if any, of traumatic intracranial findings on early head computed tomography (CT) and brain magnetic resonance imaging (MRI) to 3-month outcome in mild injury (MTBI).One hundred thirty-five MTBI patients evaluated for acute emergency departments 3 LEVEL I trauma centers were enrolled prospectively. In addition admission CT, MRI was performed 12 ± 3.9 days after injury. Univariate multivariate logistic regression used assess demographic, clinical,...
Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence persistent functional limitations for these patients is unclear.To characterize the natural history recovery daily function following mTBI vs peripheral orthopedic injury in first 12 months postinjury using data from Transforming Research and Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study, and, clinical computed tomographic (CT) scans,...
The present prognosis for the recovery of voluntary control movement in patients diagnosed as motor complete is generally poor. Herein we introduce a novel and noninvasive stimulation strategy painless transcutaneous electrical enabling pharmacological to neuromodulate physiological state spinal cord. This neuromodulation enabled locomotor networks individuals with paralysis 2-6 years American Spinal Cord Injury Association Impairment Scale (AIS) be re-engaged trained. We showed that...
<h3>Importance</h3> Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive (MDD), but little is known about factors that modify risk for these psychiatric sequelae, particularly in the civilian sector. <h3>Objective</h3> To ascertain prevalence of PTSD MDD among patients evaluated emergency department mild TBI (mTBI). <h3>Design, Setting, Participants</h3> Prospective longitudinal cohort study...
<h3>Importance</h3> Moderate to severe traumatic brain injury (msTBI) is a major cause of death and disability in the US worldwide. Few studies have enabled prospective, longitudinal outcome data collection from acute chronic phases recovery after msTBI. <h3>Objective</h3> To prospectively assess outcomes areas life function at 2 weeks 3, 6, 12 months <h3>Design, Setting, Participants</h3> This cohort study, as part Transforming Research Clinical Knowledge TBI (TRACK-TBI) was conducted 18...
Current guidelines for the care of patients with acute spinal cord injuries (SCIs) recommend maintaining mean arterial pressure (MAP) values 85-90 mm Hg 7 days after an SCI however, little evidence supports this recommendation. We sought to better inform relationship between MAP and neurological recovery. A computer system automatically collected stored q1 min physiological data from intensive unit monitors on over a 6-year period. Data 100 were collected. 74 these had American Spinal Injury...
Traumatic brain injury (TBI) is a major risk factor for the development of multiple neurodegenerative diseases. With respect to increasing prevalence TBI, new therapeutic strategies are urgently needed that will prevent secondary damage primarily unaffected tissue. Consistently, neuroinflammation has been implicated as key mediator following initial mechanical insult. Following injury, there uncertainty regarding role accumulating CCR2 + macrophages play in injury-induced neuroinflammatory...
Applications of a 3D printing process are presented. This integrates liquid-state printed components and interconnects with IC chips in all three dimensions, various orientations, multiple layers to deliver personalized system-level functionalities. As an example application, form-fitting glove is demonstrated embedded programmable heater, temperature sensor, the associated control electronics for thermotherapeutic treatment. service our authors readers, this journal provides supporting...
Abstract Data-driven discovery in complex neurological disorders has potential to extract meaningful syndromic knowledge from large, heterogeneous data sets enhance for precision medicine. Here we describe the application of topological analysis (TDA) data-driven preclinical traumatic brain injury (TBI) and spinal cord (SCI) mined Visualized Syndromic Information Outcomes Neurotrauma-SCI (VISION-SCI) repository. Through direct visualization inter-related histopathological, functional health...
Neuromodulation of spinal networks can improve motor control after cord injury (SCI). The objectives this study were to (1) determine whether individuals with chronic paralysis stand the aid non-invasive electrical stimulation their knees and hips extended without trainer assistance, (2) investigate postural be further improved following repeated sessions training. Using a double-blind, balanced, within-subject cross-over, sham-controlled design, 15 SCI various severity received...
We report white matter changes after mild traumatic brain injury and their relationship with self-reported cognitive symptoms.
In nearly all clinical and research contexts, the initial severity of a traumatic brain injury (TBI) is measured using Glasgow Coma Scale (GCS) total score. The GCS score however, may not accurately reflect level consciousness, critical indicator severity. We investigated relationship between scores consciousness in consecutive sample 2455 adult subjects assessed with 69,487 times as part multi-center Transforming Research Clinical Knowledge TBI (TRACK-TBI) study. assigned each subscale...
<h3>Importance</h3> Knowledge of differences in mild traumatic brain injury (mTBI) recovery by sex and age may inform individualized treatment these patients. <h3>Objective</h3> To identify sex-related symptom from mTBI; secondarily, to explore within women, who demonstrate poorer outcomes after TBI. <h3>Design, Setting, Participants</h3> The prospective cohort study Transforming Research Clinical Traumatic Brain Injury (TRACK-TBI) recruited 2000 patients with mTBI February 26, 2014, July 3,...
Effective team science requires procedural harmonization for rigor and reproducibility. Multicenter studies across experimental modalities (domains) can help accelerate translation. The Translational Outcomes Project in NeuroTrauma (TOP-NT) is a pre-clinical traumatic brain injury (TBI) consortium charged with establishing validating noninvasive TBI assessment tools through science. Here, we present practical approaches of research five centers providing needed vocabulary structure to...
Traumatic brain injury (TBI) has long been a leading cause of death and disability, yet research failed to successfully translate findings from the pre-clinical, animal setting into clinic. One factor that contributes significantly this struggle is heterogeneity observed in clinical where patients present with injuries varying types, severities, comorbidities. Modeling highly varied population laboratory remains challenging. Given feasibility constraints, individual laboratories often focus...
Glutamate, the major excitatory neurotransmitter in CNS, is implicated both normal neurotransmission and excitotoxicity. Numerous vitro findings indicate that ionotropic glutamate receptor, AMPAR, can rapidly traffic from intracellular stores to plasma membrane, altering neuronal excitability. These receptor trafficking events are thought be involved CNS plasticity as well learning memory. AMPAR has recently been shown regulated by glial release of proinflammatory cytokine tumor necrosis...
Secreted IgM and complement are important mediators in the optimal initiation of primary T-dependent humoral immune responses. serves as a natural adjuvant by enhancing immunogenicity protein antigens, perhaps result IgM's ability to facilitate antigen deposition onto follicular dendritic cells (FDCs) promote rapid germinal center (GC) formation. To understand how enhances adaptive responses, we investigated mechanism which IgM-containing complexes (IgM-IC) transported FDCs first step GC We...
Fundamental differences in the anatomy and function of corticospinal tract support enhanced recovery leg hand after lateralized spinal cord injury primates compared to rodents, emphasizing importance primate models for repair therapies.
Previous studies that have evaluated the prognostic value of abnormal changes in signals on T2-weighted MRI scans an injured spinal cord focused longitudinal extent this signal abnormality sagittal plane. Although transverse injury and degree spared white matter been shown to be important for predicting outcomes preclinical animal models (SCI), surprisingly little is known about altered T2 relaxivity humans axial plane.The authors undertook a retrospective chart review 60 patients who met...