A5041834364- Advanced Sensor and Energy Harvesting Materials
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Tactile and Sensory Interactions
- Electrowetting and Microfluidic Technologies
- Electrochemical sensors and biosensors
- Conducting polymers and applications
- Gas Sensing Nanomaterials and Sensors
- Neuroscience and Neural Engineering
- Advanced Chemical Sensor Technologies
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- Mechanical and Optical Resonators
- Interactive and Immersive Displays
- Advanced biosensing and bioanalysis techniques
- Force Microscopy Techniques and Applications
- Electrical and Bioimpedance Tomography
- Nanomaterials and Printing Technologies
- Electrostatics and Colloid Interactions
- Non-Invasive Vital Sign Monitoring
- Polydiacetylene-based materials and applications
- Additive Manufacturing and 3D Printing Technologies
- Advancements in Transdermal Drug Delivery
- 3D Printing in Biomedical Research
BioElectronics (United States)
2019-2025
University of California, Los Angeles
2016-2025
Samueli Institute
2022
La Jolla Bioengineering Institute
2022
Terasaki Foundation
2021
Los Angeles City College
2019-2020
University of California System
2019
University of California, Berkeley
2015-2017
Lawrence Berkeley National Laboratory
2016-2017
Stanford University
2011-2016
Significance The inherent inaccessibility of sweat in sedentary individuals large volume (≥10 µL) for on-demand and situ analysis has limited our ability to capitalize on this noninvasive rich source information. Through devising an electrochemically enhanced, programmable, miniaturized iontophoresis interface, integrated a wearable sensing platform, we demonstrated method periodic extraction analysis. system can be programmed induce with various secretion profiles, which combination the...
Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement clinical applications not easily accessible due to its strict procedures dependence on pH. pH balance body fluids greatly affects metabolic reactions transport Here, we demonstrate a wearable electrochemical device continuous monitoring using disposable flexible array Ca(2+) sensors that interfaces with printed circuit board. This platform enables real-time quantitative...
Printing technologies offer large‐area, high‐throughput production capabilities for electronics and sensors on mechanically flexible substrates that can conformally cover different surfaces. These enable a wide range of new applications such as low‐cost disposable health monitoring wearables, extremely large format electronic displays, interactive wallpapers, sensing arrays. Solution‐processed carbon nanotubes have been shown to be promising candidate printing processes, offering stable...
A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, Hg ions are chosen as target analytes detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au Bi microelectrodes. The oxidation peaks these calibrated compensated by incorporating a skin temperature sensor. High selectivity, repeatability, flexibility the sensor arrays presented. Human sweat urine samples collected...
Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is in sweat nanomolar concentrations. Previous wearable sensing systems are limited to analytes the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array exploits previously unreported cortisol aptamer coupled nanometer-thin-film In2O3 FETs. Cortisol levels...
Applications of a 3D printing process are presented. This integrates liquid-state printed components and interconnects with IC chips in all three dimensions, various orientations, multiple layers to deliver personalized system-level functionalities. As an example application, form-fitting glove is demonstrated embedded programmable heater, temperature sensor, the associated control electronics for thermotherapeutic treatment. service our authors readers, this journal provides supporting...
Abstract Gelatin methacryloyl (GelMA) is a widely used hydrogel with skin‐derived gelatin acting as the main constituent. However, GelMA has not been in development of wearable biosensors, which are emerging devices that enable personalized healthcare monitoring. This work highlights potential for biosensing applications by demonstrating fully solution‐processable and transparent capacitive tactile sensor microstructured core dielectric layer. A robust chemical bonding reliable encapsulation...
Embedding microfluidic architectures with microneedles enables fluid management capabilities that present new degrees of freedom for transdermal drug delivery. To this end, fabrication schemes can simultaneously create and integrate complex millimeter/centimeter-long structures micrometer-scale microneedle features are necessary. Accordingly, three-dimensional (3D) printing techniques suitable candidates because they allow the rapid realization customizable yet intricate features. However,...
Therapeutic drug monitoring is essential for dosing pharmaceuticals with narrow therapeutic windows. Nevertheless, standard methods are imprecise and involve invasive/resource-intensive procedures long turnaround times. Overcoming these limitations, we present a microneedle-based electrochemical aptamer biosensing patch (μNEAB-patch) that minimally invasively probes the interstitial fluid (ISF) renders correlated, continuous, real-time measurements of circulating drugs' pharmacokinetics. The...
Abstract Real‐time monitoring of human health can be significantly improved by designing novel electronic skin (E‐skin) platforms that mimic the characteristics and sensitivity skin. A high‐quality E‐skin platform simultaneously monitor multiple physiological metabolic biomarkers without introducing discomfort or irritation is an unmet medical need. Conventional E‐skins are either monofunctional made from elastomeric films do not include key synergistic features natural skin, such as...
Abstract Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised autonomously provide frequent, real-time, and accurate measures biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system devised, which capable sampling, routing, compartmentalization for biomarker analysis. At its core, network individually-addressable microheater-controlled thermo-responsive...
We devised a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.
A ferrobotic system is devised to implement diverse, efficient, and automated microfluidic logistics.
Significance To achieve the mission of personalized medicine, centering on delivering right drug to patient at dose, therapeutic monitoring solutions are necessary. By devising a surface engineering strategy, we created voltammetric sensing interface, featuring an “undistorted potential window,” within which target electroactive drug’s response is dominant and interference eliminated, rendering reliable quantification in noninvasively retrievable biofluids (sweat saliva). Leveraging this...
Recent advances in microelectronics, microfluidics, and electrochemical sensing platforms have enabled the development of an emerging class fully integrated personal health monitoring devices that exploit sweat to noninvasively access biomarker information. Despite such advances, effective sampling remains a significant challenge for reliable analysis, with many existing methods requiring active stimulation (e.g., iontophoresis, exercise, heat). Natural perspiration offers suitable...
Abstract The use of conducting polymers such as poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) for the development soft organic bioelectronic devices, electrochemical transistors (OECTs), is rapidly increasing. However, directly manipulating polymer thin films on substrates remains challenging, which hinders conformable devices. A facile transfer‐printing from conventional rigid to flexible offers an alternative solution. In this work, it reported that PEDOT:PSS glass...
Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes established electrochemical functionalities are rigid mechanically mismatched tissue. Whereas conductive materials tissue-like softness stretchability demonstrated, when applied electrochemically probe tissue, their performance is distorted by strain corrosion. We devise a layered architectural composite design...
Wearable piezoresistive sensors are being developed as electronic skins (E-skin) for broad applications in human physiological monitoring and soft robotics. Tactile with sufficient sensitivities, durability, large dynamic ranges required to replicate this critical component of the somatosensory system. Multiple micro/nanostructures, materials, sensing modalities have been reported address need. However, a trade-off arises between device performance complexity. Inspired by microstructure...
In this work, we demonstrate a novel and cost-effective approach to implement disposable microfluidic contactless impedance cytometer. Conventional methods for single cell cytometry use microfabricated electrodes in direct contact with the buffer measure changes of its electrical when cells pass through applied electric field. However, requires expensive microfabrication electrodes, also, fabricated cannot be reused without thorough time-consuming cleaning process. Here, introduce allow...
Abstract Wearable electroenzymatic sensors enable monitoring of clinically informative biomolecules in epidermally retrievable biofluids. Conventional wearable enzymatic utilize Prussian Blue (a redox mediator) to achieve selectivity against electroactive interferents. However, the use presents fundamental challenges including: 1) susceptibility sensor response dynamic concentration variation ionic species and 2) poor operational stability due degradation its framework. As an alternative...
The controlled immobilization of proteins on solid-state surfaces can play an important role in enhancing the sensitivity both affinity-based biosensors and probe-free sensing platforms. Typical methods controlling orientation probe a sensor surface involve chemistry-based techniques. Here, we present method tunably using electric field. We study ability to orient molecules by immobilizing IgG microchannels while applying lateral fields. use atomic force microscopy qualitatively...